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Infectious Disease: Candida
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Total 1841 results found since Jan 2013.
I κBζ is an essential mediator of immunity to oropharyngeal candidiasis
Cell Host Microbe. 2023 Sep 11:S1931-3128(23)00341-4. doi: 10.1016/j.chom.2023.08.016. Online ahead of print.ABSTRACTFungal infections are a global threat; yet, there are no licensed vaccines to any fungal pathogens. Th17 cells mediate immunity to Candida albicans, particularly oropharyngeal candidiasis (OPC), but essential downstream mechanisms remain unclear. In the murine model of OPC, IκBζ (Nfkbiz, a non-canonical NF-κB transcription factor) was upregulated in an interleukin (IL)-17-dependent manner and was essential to prevent candidiasis. Deletion of Nfkbiz rendered mice highly susceptible to OPC. IκBζ was dispe...
Source: Cell Host and Microbe - September 19, 2023 Category: Microbiology Authors: Tiffany C Taylor Bianca M Coleman Samyuktha P Arunkumar Ipsita Dey John T Dillon Nicole O Ponde Amanda C Poholek Daniella M Schwartz Mandy J McGeachy Heather R Conti Sarah L Gaffen Source Type: research
Leber congenital amaurosis as the initial and essential manifestation in a Chinese patient with autoimmune polyglandular syndrome Type 1
ConclusionWe presented one case diagnosed with APS-1 based on clinical characteristics and genetic analysis. Our study demonstrated that LCA could serve as a warning sign for APS-1 and a potential trigger of early screening, which might prevent life-threatening complications.
Source: Documenta Ophthalmologica - September 16, 2023 Category: Opthalmology Source Type: research
< em > Salvia dumetorum < /em > essential oil: GC-MS analysis, antibacterial activity and effect on the formation of < em > Streptococcus mutans < /em > biofilms
In this study SDEO was screened for its antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Candida albicans and the amount of biofilm formed by Streptococcus mutans bacteria. For the first time the chemical composition of SDEO growing in Central Kazakhstan was established. The results obtained from GC-MS showed the predominance of sesquiterpenoids (54.15%). The antibacterial study results showed that SDEO exhibited strong antibacterial activity against B. subtilis and S. aureus in vitro and also demonstrated an inhibitory effect on S. mutans biofilm formation on 1% sucrose medium...
Source: Natural Product Research - September 11, 2023 Category: Biochemistry Authors: Yana К Levaya Gayane А Atazhanova Тomas Kacergius Svetlana А Ivasenko Alexandr B Marchenko Margarita Yu Ishmuratova Мarlen К Smagulov Source Type: research
GSE199422 Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA
Contributors : Fiona Alings ; Karin Scharmann ; Cristian Eggers ; Bettina B öttcher ; Mikołaj Sokołowski ; Ekaterina Shvetsova ; Puneet Sharma ; Joël Roth ; Leon Rashiti ; Sebastian Glatt ; Sascha Brunke ; Sebastian A LeidelSeries Type : OtherOrganism : Candida albicansFungal pathogens threaten ecosystems and human health. Understanding the molecular basis of their virulence is key to develop new treatment strategies. Here, we characterize NCS2*, a point mutation identified in a clinical baker's yeast isolate. Ncs2 is essential for 2-thiolation of tRNA and the NCS2* mutation leads to increased thiolation at body temper...
Source: GEO: Gene Expression Omnibus - September 5, 2023 Category: Genetics & Stem Cells Tags: Other Candida albicans Source Type: research
Surgical treatment of < em > Candida albicans < /em > spondylodiscitis
CONCLUSION: In summary, evaluation for fungal infection is essential in all cases of unexplained spinal infection in immunocompromised patients, regardless of presentation. If the antifungal treatment proves ineffective, a surgical approach is typically employed for the management of fungal spondylodiscitis. Our report details a successful case of fungal spondylodiscitis treated with a surgical approach and highlights the potential for a fungal infection to be a causative factor in noncompressive myelopathy, which may be sometimes mistaken for radiation myelitis.PMID:37663715 | PMC:PMC10473295 | DOI:10.1097/MS9.0000000000001114
Source: Annals of Medicine - September 4, 2023 Category: Internal Medicine Authors: Prashant Adhikari Nishma Pokharel Sulochana Khadka Ishwar Lohani Prakash Kafle Sandeep Bhandari Bhaskar Raj Pant Pradeep Raj Regmi Emre Acaro ğlu Source Type: research
Molecules, Vol. 28, Pages 6340: Exploration of Baicalein-Core Derivatives as Potent Antifungal Agents: SAR and Mechanism Insights
This study presents potential antifungal agents with synergistic effects that can effectively inhibit hypha formation. It also provides new insights into the MoA.
Source: Molecules - August 30, 2023 Category: Chemistry Authors: Heyang Zhou Niao Yang Wei Li Xuemi Peng Jiaxiao Dong Yuanying Jiang Lan Yan Dazhi Zhang Yongsheng Jin Tags: Article Source Type: research
Cervicovaginal Bacillus velezensis Isolate: A Potential Probiotic and an Antagonist Against Candida and Staphylococcus
In this study, we aimed to evaluate the probiotic properties of a cervicovaginal isolate, obtained from a gynecologically healthy woman and assess its antagonistic effect against various microorganisms isolated from the vagina. Cytological examination was performed using Papanicolaou staining, and the isolated microorganism was identified via 16S Ribosomal RNA Gene Sequence Analysis. Probiotic characteristics were evaluated by determining the tolerance of the isolate to low pH, different NaCl concentrations, and bile salts. Bacterial adherence to stainless steel sheets, antibiotic susceptibility, and antimicrobial activity...
Source: Current Microbiology - August 29, 2023 Category: Microbiology Authors: Gulcan Sahal Hanife Guler Donmez Mehmet Sinan Beksac Source Type: research
The Ypk1 protein kinase signaling pathway is rewired and not essential for viability in < i > Candida albicans < /i >
by Bernardo Ram írez-Zavala, Ines Krüger, Andreas Wollner, Sonja Schwanfelder, Joachim Morschhäuser
Protein kinases are central components of almost all signaling pathways that control cellular activities. In the model organismSaccharomyces cerevisiae, the paralogous protein kinases Ypk1 and Ypk2, which control membrane lipid homeostasis, are essential for viability, and previous studies strongly indicated that this is also the case for their single ortholog Ypk1 in the pathogenic yeastCandida albicans. Here, using FLP-mediated inducible gene deletion, we reveal thatC.albicans ypk1Δ mutants are viable but slow-growing...
Source: PLoS Genetics - August 10, 2023 Category: Genetics & Stem Cells Authors: Bernardo Ram írez-Zavala Source Type: research
Rate of dilution and redox ratio influence the refolding efficiency of recombinant fungal dehydrogenases
Int J Biol Macromol. 2023 Aug 5:126163. doi: 10.1016/j.ijbiomac.2023.126163. Online ahead of print.ABSTRACTDehydrogenases from fungi are attracting attention as industrial biocatalysts due to their high activity and chiral selectivity. However, these enzymes form insoluble aggregates when overexpressed in E. coli, limiting their industrial application. In the present study, we report the systematic development of a refolding process for selected, industrially relevant fungal dehydrogenases, viz., formate dehydrogenase from Candida boidinii (CbFDH) and formate and alcohol dehydrogenases from Geotrichum candium (GcFDH and Gc...
Source: International Journal of Biological Macromolecules - August 7, 2023 Category: Biochemistry Authors: Snehal D Ganjave Ruchika Annie O'Niel Pramod P Wangikar Source Type: research
