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Procedure: Kidney Transplant

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Total 1728 results found since Jan 2013.

Current understanding of the molecular mechanisms of circulating permeability factor in focal segmental glomerulosclerosis
We present an overview of the current understanding of the engagement of distinct molecules and immune cells in FSGS pathogenesis while highlighting critical knowledge gaps that require attention. A thorough characterization of these intricate immune mechanisms holds the potential to identify noninvasive biomarkers that can accurately identify patients at high risk of post-transplant recurrence. Such knowledge can pave the way for the development of targeted and personalized therapeutic approaches in the management of FSGS.
Source: Frontiers in Immunology - September 19, 2023 Category: Allergy & Immunology Source Type: research

Activated carbon derived from wood biochar for Amperometric sensing of Ammonia for early screening of chronic kidney disease
In this study, we have elucidated the functionality and usefulness of a wearable microelectronic research prototype integrated with an HTC-activated carbon @RTIL-based electrochemical sensing platform for detecting ammonia levels released from the skin as a marker for chronic kidney disease screening. By enabling early detection and monitoring, these platforms can facilitate timely interventions, such as lifestyle modifications, medication adjustments, or referral to nephrology specialists. This proactive approach can potentially slow down disease progression, minimize the need for dialysis or transplantation, and ultimate...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Ivneet Banga Anirban Paul Vikram Narayanan Dhamu Annapoorna Hochihally Ramasubramanya Sriram Muthukumar Shalini Prasad Source Type: research

Corticosteroid Dose in Kidney Transplantation and Its Effect on Surgical Complication: A Systematic Review
CONCLUSIONS: We investigated the potential benefits of reducing the dose of corticosteroids following kidney transplant. Findings suggested thatreducing the dose of corticosteroids following kidney transplant might be a viable strategy for minimizing the risk of surgical complications. However, it is essential to note that the optimal dosage and duration of corticosteroid therapy after kidney transplant may vary for each patient and should be carefully determined by the health care provider.PMID:37698397 | DOI:10.6002/ect.2023.0198
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Nasser Simforoosh Amirhossein Nayebzade Mehdi Dadpour Saeed Rohani Source Type: research

Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan. « Back to Top Trials of Xenotransplantation of Pig Organs into Humans Continue https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/ Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants in...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Extracellular Vesicles and Hypertension
Adv Exp Med Biol. 2023;1418:69-80. doi: 10.1007/978-981-99-1443-2_5.ABSTRACTHypertension implicates multiple organs and systems, accounting for the majority of cardiovascular diseases and cardiac death worldwide. Extracellular vesicles derived from various types of cells could transfer a variety of substances such as proteins, lipids, and nucleic acids from cells to cells, playing essential roles in both physiological and pathological processes. Extracellular vesicles are demonstrated to be closely associated with the development of essential hypertension by mediating the renin-angiotensin-aldosterone system and crosstalk ...
Source: Advances in Experimental Medicine and Biology - August 21, 2023 Category: Research Authors: Heng Tang Yuxue Hu Jiali Deng Source Type: research

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Organ retrieval and preservation
The success of organ transplantation can be attributed to many factors but ultimately depends upon retrieval and preservation techniques to maintain the quality of an organ. Thoracic and abdominal organs from deceased donors are retrieved during a multi-organ procedure. The organs are flushed and cooled in  situ with preservation solution followed by dissection and removal. With high-risk donors, such as donation after circulatory death, rapid in-situ cooling is essential to minimize the injury. Live kidney donation is becoming increasingly popular and the disincentives have been significantly reduce d by the introduction...
Source: Surgery (Medicine Publishing) - July 28, 2023 Category: Surgery Authors: Michael L. Nicholson, Sarah A. Hosgood Tags: Transplantation Source Type: research