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Lynch syndrome-associated epithelial ovarian cancer and its immunological profile
CONCLUSION: MMR-d, MSI, and TILs are also seen in Lynch syndrome-associated ovarian cancers making these potential candidates for checkpoint-based immunotherapy. The clinical impact from immune evasion through loss of B2M needs to be investigated further in larger cohorts.PMID:34275654 | DOI:10.1016/j.ygyno.2021.07.001
Source: Gynecologic Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Maria Rasmussen Kevin Lim Eva Rambech Mads Hald Andersen Inge Marie Svane Ove Andersen Lars Henrik Jensen Mef Nilbert Christina Therkildsen Source Type: research

Isolation and Characterization of Chemo-Resistant Stem Cells from a Mouse Model of Hereditary Non-Polyposis Colon Cancer
CONCLUSION: In the present study, a stem cell model for HNPCC was validated and offered a novel experimental approach to test stem cell-targeted alternatives to drug-resistant therapy.PMID:34234468 | PMC:PMC8254583 | DOI:10.2147/SCCAA.S312929
Source: Stem Cells and Cloning: Advances and Applications - July 8, 2021 Category: Stem Cells Authors: Nitin Telang Source Type: research

Continuing difficulties in interpreting CNV data: lessons from a genome-wide CNV association study of Australian HNPCC/lynch syndrome patients
Background: Hereditary non-polyposis colorectal cancer (HNPCC)/Lynch syndrome (LS) is a cancer syndrome characterised by early-onset epithelial cancers, especially colorectal cancer (CRC) and endometrial cancer. The aim of the current study was to use SNP-array technology to identify genomic aberrations which could contribute to the increased risk of cancer in HNPCC/LS patients. Methods: Individuals diagnosed with HNPCC/LS (100) and healthy controls (384) were genotyped using the Illumina Human610-Quad SNP-arrays. Copy number variation (CNV) calling and association analyses were performed using Nexus software, with signifi...
Source: BMC Medical Genomics - March 26, 2013 Category: Genetics & Stem Cells Authors: Bente Talseth-PalmerElizabeth HollidayTiffany-Jane EvansMark McEvoyJohn AttiaDesma GriceAmy MassonCliff MeldrumAllan SpigelmanRodney Scott Source Type: research