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Lynch syndrome-associated epithelial ovarian cancer and its immunological profile
CONCLUSION: MMR-d, MSI, and TILs are also seen in Lynch syndrome-associated ovarian cancers making these potential candidates for checkpoint-based immunotherapy. The clinical impact from immune evasion through loss of B2M needs to be investigated further in larger cohorts.PMID:34275654 | DOI:10.1016/j.ygyno.2021.07.001
Source: Gynecologic Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Maria Rasmussen Kevin Lim Eva Rambech Mads Hald Andersen Inge Marie Svane Ove Andersen Lars Henrik Jensen Mef Nilbert Christina Therkildsen Source Type: research

Unsolicited information letters to increase awareness of Lynch syndrome and familial colorectal cancer: reactions and attitudes
AbstractDissemination of information on a genetically increased risk should according to guidelines primarily be family-mediated. Incomplete and incorrect information spread has, however, been documented and implies missed possibilities for prevention. In Denmark, the national HNPCC register has been granted an exception to send unsolicited letters with information on hereditary colorectal cancer and an invitation to genetic counseling to members of families with familial and hereditary colorectal cancer. To evaluate this approach, we investigated reactions and attitudes to unsolicited letters in 708 members of families wi...
Source: Familial Cancer - April 12, 2018 Category: Cancer & Oncology Source Type: research