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Abstract B07: Molecular characterization of colorectal cancer in West Africans
Conclusion: In this dataset of relatively young onset CRC cases, a large percentage of cases are of the HNPCC subtype. Use of IHC as a universal screening test for all CRC cases, as well as follow-up referral for genetic counseling, could be an innovative approach to CRC cancer control in the population.Citation Format: Aliyu Lawan, Galina Khramtsova, David Irabor, Mustapha Ajani, Lise Sveen, Yusuf M. Abdullah, Henry O. Ebili, Umar Saad, John O. Ogunbiyi, Olufunmilayo I. Olopade, Abideen O. Oluwasola. Molecular characterization of colorectal cancer in West Africans. [abstract]. In: Proceedings of the AACR Special Conferenc...
Source: Cancer Research - January 30, 2017 Category: Cancer & Oncology Authors: Aliyu Lawan, Galina Khramtsova, David Irabor, Mustapha Ajani, Lise Sveen, Yusuf M. Abdullah, Henry O. Ebili, Umar Saad, John O. Ogunbiyi, Olufunmilayo I. Olopade, Abideen O. Oluwasola Tags: Molecular Diagnostics Source Type: research

Abstract IA27: Understanding more about risk and prognostic factors: Lessons from the Colon Cancer Family Registry
Conclusions: The CCFR has shed light on many environmental factors, genetics and tumor characteristics that are related to both incidence and survival. Information gained from studies using this resource provides insight into the biology of this common cancer and importantly may help target messaging on prevention, inform the development of interventions, or tailor recommendations for CRC survivorship care. The greater scientific community has access to this rich resource.Citation Format: Polly A. Newcomb. Understanding more about risk and prognostic factors: Lessons from the Colon Cancer Family Registry. [abstract]. In: P...
Source: Cancer Research - January 30, 2017 Category: Cancer & Oncology Authors: Polly A. Newcomb Tags: Outcomes, Survivorship, and Health Disparities Source Type: research

Abstract 18: Molecular characterization of Brazilian patients suspected for Lynch syndrome
Lynch syndrome (LS), former known as Hereditary Non Polyposis Colorectal cancer (HNPCC), accounts for 3-5% of all colorectal cancers (CRC) and is inherited in an autossomal dominant fashion. This syndrome is characterized by early CRC onset, high incidence of tumors in the ascending colon, excess of synchronous and metachronous tumors, and accelerated transition adenoma-carcinoma (2-3 years). Nowadays, LS is regarded of patients who carry deleterious germline mutations in one of the five Mismatch repair genes, such as MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MutS homolog 6 (MSH6), post-meiotic segregation increased 1 ...
Source: Cancer Research - December 12, 2014 Category: Cancer & Oncology Authors: Silva, F. C., Torrezan, G. T., Figueiredo, M. C., Ferreira, J. R. O., Santos, E. M., Nakagawa, W. T., Aguiar-Junior, S., Rossi, B. M., Ferreira, F. O., Carraro, D. M. Tags: Poster Presentations Source Type: research

Abstract A27: BLM overexpression promotes tumorigenicity in an azoxymethane/dextran sulfate (AOM/DSS) murine model of intestinal cancer
The role of genomic instability in colorectal cancer susceptibility is well established by studies of hereditary non-polyposis colon cancer (HNPCC), its associated disruption of DNA mismatch repair, and other DNA repair deficiencies that predispose to colon cancer. DNA repair deficiency that results in loss of capacity to maintain the genome leads to increased mutation or chromosome instability that in turn increases tumor formation. In some recent experiments using mouse models of cancer, deletion of genomic housekeeping genes promoted tumorigenesis. The Blm gene encodes a RecQ helicase that represses aberrant homologous ...
Source: Molecular Cancer Research - November 13, 2014 Category: Cancer & Oncology Authors: Ebede, K., McIlhatton, M., Hankey, W., Groden, J. Tags: Target Discovery and Validation: Poster Presentations - Proffered Abstracts Source Type: research