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Abstract IA27: Understanding more about risk and prognostic factors: Lessons from the Colon Cancer Family Registry
Conclusions: The CCFR has shed light on many environmental factors, genetics and tumor characteristics that are related to both incidence and survival. Information gained from studies using this resource provides insight into the biology of this common cancer and importantly may help target messaging on prevention, inform the development of interventions, or tailor recommendations for CRC survivorship care. The greater scientific community has access to this rich resource.Citation Format: Polly A. Newcomb. Understanding more about risk and prognostic factors: Lessons from the Colon Cancer Family Registry. [abstract]. In: P...
Source: Cancer Research - January 30, 2017 Category: Cancer & Oncology Authors: Polly A. Newcomb Tags: Outcomes, Survivorship, and Health Disparities Source Type: research

Continuing difficulties in interpreting CNV data: lessons from a genome-wide CNV association study of Australian HNPCC/lynch syndrome patients
Background: Hereditary non-polyposis colorectal cancer (HNPCC)/Lynch syndrome (LS) is a cancer syndrome characterised by early-onset epithelial cancers, especially colorectal cancer (CRC) and endometrial cancer. The aim of the current study was to use SNP-array technology to identify genomic aberrations which could contribute to the increased risk of cancer in HNPCC/LS patients. Methods: Individuals diagnosed with HNPCC/LS (100) and healthy controls (384) were genotyped using the Illumina Human610-Quad SNP-arrays. Copy number variation (CNV) calling and association analyses were performed using Nexus software, with signifi...
Source: BMC Medical Genomics - March 26, 2013 Category: Genetics & Stem Cells Authors: Bente Talseth-PalmerElizabeth HollidayTiffany-Jane EvansMark McEvoyJohn AttiaDesma GriceAmy MassonCliff MeldrumAllan SpigelmanRodney Scott Source Type: research