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The CAPP II trial of aspirin in Lynch syndrome/HNPCC: is it time for everyone to be treated?
Source: Familial Cancer - January 9, 2021 Category: Cancer & Oncology Source Type: research

Unsolicited information letters to increase awareness of Lynch syndrome and familial colorectal cancer: reactions and attitudes
AbstractDissemination of information on a genetically increased risk should according to guidelines primarily be family-mediated. Incomplete and incorrect information spread has, however, been documented and implies missed possibilities for prevention. In Denmark, the national HNPCC register has been granted an exception to send unsolicited letters with information on hereditary colorectal cancer and an invitation to genetic counseling to members of families with familial and hereditary colorectal cancer. To evaluate this approach, we investigated reactions and attitudes to unsolicited letters in 708 members of families wi...
Source: Familial Cancer - April 12, 2018 Category: Cancer & Oncology Source Type: research

First description of mutational analysis of MLH1, MSH2 and MSH6 in Algerian families with suspected Lynch syndrome
In this study, we confirmed that MSH2 , MLH1, and MSH6 contribute to CRC susceptibility. This work represents the implementation of a diagnostic algorithm for the identification of Lynch syndrome patients in Algerian families.
Source: Familial Cancer - July 27, 2016 Category: Cancer & Oncology Source Type: research

Survival in familial colorectal cancer: a Danish cohort study
Abstract The monogenic Lynch syndrome (LS) is associated with better survival in colorectal cancer (CRC) patients. Whether family history of CRC affects CRC prognosis in general remains unclear. We evaluated overall mortality in a Danish cohort of CRC patients comparing patients with a family history (FHpos) to those without (FHneg) with focus on patients from non-syndromic families, thus FHpos patients were further divided into a non-syndromic group (FHNS) and a HNPCC/LS group (FHHNPCC). We included CRC patients diagnosed 1995–1998. First degree relatives were identified using Danish population registries and f...
Source: Familial Cancer - May 11, 2015 Category: Cancer & Oncology Source Type: research