This page shows you your search results in order of relevance. This is page number 17.

Order by Relevance | Date

Total 244 results found since Jan 2013.

Constitutional MLH1 Methylation Is a Major Contributor to Mismatch Repair-Deficient, MLH1-Methylated Colorectal Cancer in Patients Aged 55 Years and Younger
CONCLUSIONS: Although rare overall, a significant proportion of younger patients with MLH1-methylated CRC had underlying constitutional MLH1 methylation. Routine testing for this high-risk mechanism is warranted in patients aged ≤55 years for a timely and accurate molecular diagnosis that will significantly alter their clinical management while minimizing additional testing.PMID:37433431 | DOI:10.6004/jnccn.2023.7020
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 11, 2023 Category: Cancer & Oncology Authors: Megan P Hitchins Estela D ámaso Rocio Alvarez Lisa Zhou Yajing Hu Marcio A Diniz Marta Pineda Gabriel Capella Rachel Pearlman Heather Hampel Source Type: research

Lynch Syndrome Risk Reducing Surgery – Lisa ’ s Story
Hi, I’m very new to all this so don’t really know where to start! I have a condition called Lynch Syndrome or HNPCC. My wonderful mother died 10 years ago at the age of 52 from Endometrial cancer. She previously had Bowel cancer too and at the time a link was not made but we now know she must have has Lynch syndrome too. Lynch syndrome sufferers have an 80% chance of developing Bowel cancer, a 60% chance of developing Endometrial Cancer and 10% chance of developing Ovarian cancer, plus other cancers too. Which is what has lead me to this site. In a few weeks I will be having a Total Hysterectomy and Bilateral ...
Source: The Hysterectomy Association - October 16, 2012 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Health endometrial cancer hysterectomy stories lynch syndrome ovarian cancer Source Type: news

A Novel Mutation of < em > MSH2 < /em > Gene in a Patient with Lynch Syndrome Presenting with Thirteen Metachronous Malignancies
J Clin Med. 2023 Aug 24;12(17):5502. doi: 10.3390/jcm12175502.ABSTRACTLynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), accounts for 2-3% of all colorectal cancers. This autosomal dominant disorder is associated with a predisposition to endometrial, stomach, small bowel, pancreatic, biliary tract, ovary, urinary tract, brain, and skin tumors. Lynch syndrome is caused by the mutation of the MLH1, MSH2 (EPCAM), MSH6, and PMS2 genes. In this article, a case study of a 70-year-old female patient with Lynch syndrome is presented. Over a span of 30 years, the patient underwent multiple surgica...
Source: Clinical Colorectal Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Ugne Silinskaite Edita Gavelien ė Rokas Stulpinas Ramunas Janavicius Tomas Poskus Source Type: research