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Total 244 results found since Jan 2013.

Validation of microsatellite instability histology scores with Bethesda guidelines in hereditary nonpolyposis colorectal cancer
Conclusions: The MSI scoring systems, MsPath, and PathScore, are reliable systems and effectively correlated with BG for predicting patients who need advanced analysis techniques because of the risk of HNPCC.
Source: Journal of Cancer Research and Therapeutics - June 23, 2017 Category: Cancer & Oncology Authors: Mustafa Kaya Fatih Basak Abdullah Sisik Mustafa Hasbahceci Gurhan Bas Orhan Alimoglu Cumhur Sel & #231;uk Topal Gozde Kir Source Type: research

Advances in Identification of Susceptibility Gene Defects of Hereditary Colorectal Cancer
Colorectal cancer (CRC) is a common malignant tumor of the digestive system worldwide, associated with hereditary genetic features. CRC with a Mendelian genetic predisposition accounts for approximately 5-10% of total CRC cases, mainly caused by a single germline mutation of a CRC susceptibility gene. The main subtypes of hereditary CRC are hereditary non-polyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP). With the rapid development of genetic testing methods, especially next-generation sequencing technology, multiple genes have now been confirmed to be pathogenic, including DNA repair or DNA mism...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qiang Liu, Yue-Qiu Tan Tags: Review Source Type: research

Expectations and psychological issues before genetic counseling: analysis of distress determinant factors
ConclusionsGreater level of distress identified on females, single and younger subjects.
Source: Hereditary Cancer in Clinical Practice - April 28, 2020 Category: Cancer & Oncology Source Type: research

Copy Number Variants Captured by the Array Comparative Genomic Hybridization in a Cohort of Patients Affected with Hereditary Colorectal Cancer in Sri Lanka: The First CNV Analysis Study of the Hereditary Colorectal Cancer in the Sri Lankan Population
CONCLUSION: This study shows that CNVs are likely contributors to the colorectal cancer predisposition in a small but significant proportion of patients affected with hereditary colorectal cancer in this cohort. Further studies have to perform to get a better understanding on the contribution of CNVs to the cancer predisposition in this cohort of patients in the Sri Lankan population.PMID:34181357 | DOI:10.31557/APJCP.2021.22.6.1957
Source: Asian Pacific Journal of Cancer Prevention - June 28, 2021 Category: Cancer & Oncology Authors: Prabhavi Wijesiriwardhana Kalum Wettasinghe Vajira H W Dissanayeke Source Type: research