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Surgical strategies for hereditary colorectal cancer
Chirurgie (Heidelb). 2023 Mar 1. doi: 10.1007/s00104-023-01823-y. Online ahead of print.ABSTRACTHereditary colorectal cancer (hCRC) represents a major diagnostic and therapeutic challenge. In addition to the usual diagnostic methods, the family history, histological confirmation and mutation analysis play an important role in identifying the type of hereditary CRC. The diagnosis and classification of hCRC are carried out based on the anamnesis, clinical presentation and histology and the further treatment is determined depending on the underlying type of hCRC. For familial adenomatous polyposis (FAP) coloproctomucosectomy ...
Source: Cancer Control - March 1, 2023 Category: Cancer & Oncology Authors: M Kelm A Wiegering C-T Germer S Flemming Source Type: research

Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature
It is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist, available data suggest early onset and synchronous cancers are synonymous to this group. We have reported an unusual case of multiple synchronous colorectal cancers in a young man with ulcerative colitis and Lynch syndrome also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC) gene mutation. We propose that conducting a detailed genetic mutation profile in LS patients ma...
Source: Frontiers in Oncology - December 22, 2022 Category: Cancer & Oncology Source Type: research

Deciding the operation type according to mismatch repair status among hereditary nonpolyposis colorectal cancer patients: should a tailored approach be applied, or does one size fit all?
CONCLUSIONS: Significantly better overall survival and higher rate of metachronous CRC exist in dMMR subgroup of HNPCC patients comparing with pMMR subgroup. Extended colectomy significantly improved DFS and was thus recommended for dMMR subgroup but not pMMR subgroup of HNPCC patients.PMID:34187536 | PMC:PMC8243908 | DOI:10.1186/s13053-021-00186-x
Source: Clinical Colorectal Cancer - June 30, 2021 Category: Cancer & Oncology Authors: Chun-Kai Liao Yueh-Chen Lin Yu-Jen Hsu Yih-Jong Chern Jeng-Fu You Jy-Ming Chiang Source Type: research

Intraductal papillary mucinous neoplasm of the ileal heterotopic pancreas in a patient with hereditary non-polyposis colorectal cancer: A case report.
We report a case of intraductal papillary mucinous neoplasm (IPMN) originating from the ileal heterotopic pancreas in a patient with hereditary non-polyposis colorectal cancer (HNPCC). A 49-year-old woman had a past history of total colectomy and total hysterectomy with bilateral salpingo-oophorectomy due to colonic adenocarcinoma and endometrial adenocarcinoma 11 years ago. Her parents died from colonic adenocarcinoma and her sister died from colonic adenocarcinoma and endometrial adenocarcinoma. The clinician found an ileal mass with necrotic change and the mass increased in size from 1.7 cm to 2.2 cm during the past 2 y...
Source: World Journal of Gastroenterology : WJG - July 7, 2015 Category: Gastroenterology Authors: Lee SH, Kim WY, Hwang DY, Han HS Tags: World J Gastroenterol Source Type: research

Segmental vs extended colectomy in the management of hereditary nonpolyposis colorectal cancer: a systematic review and meta‐analysis
ConclusionThe optimal surgical approach in the management of HNPCC remains unclear. More adenomas and cancers occur after SC than after TC but there certainly is no evidence to suggest that more radical surgery leads to improved survival.
Source: Colorectal Disease - April 21, 2015 Category: Gastroenterology Authors: H. M. Heneghan, S. T. Martin, D. C. Winter Tags: Systematic Review Source Type: research

Hereditary Non-polyposis Colorectal Cancer: Prevention and Therapeutic Options
Abstract Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common hereditary colorectal cancer (CRC) syndrome. The first and foremost preventive measure is to identify patients with LS among CRC patients. This requires the screening of colorectal cancer through polymerase chain reaction-based microsatellite instability (MSI) testing or immunohistochemistry to look for a loss of expression of one of the mismatch repair (MMR) proteins and the referral of selected patients to genetic counseling. In LS patients, annual or biannual complete colonoscopy with chromoendosco...
Source: Current Colorectal Cancer Reports - March 19, 2015 Category: Cancer & Oncology Source Type: research

Segmental versus extended colectomy in the management of HNPCC; a systematic review and meta‐analysis
ConclusionsThe optimal surgical approach in the management of HNPCC remains unclear. More adenomas and cancers occur after segmental colectomy than after total colectomy but there certainly isn't evidence to suggest that more radical surgery leads to improved survival.This article is protected by copyright. All rights reserved.
Source: Colorectal Disease - December 16, 2014 Category: Gastroenterology Authors: Helen M Heneghan, Sean T Martin, Desmond C Winter Tags: Systematic Review Source Type: research

Determining eligibility for and preparation to kidney transplantation of a patient with Lynch syndrome - a case report and literature review.
Conclusions: The risk of recurrence or new development of cancer related to immunosuppressive treatment should be considered on a case-by-case basis. In patients with a history or high risk of cancer, immunosuppression protocols based on the m-TOR pathway inhibitors should be used, if possible. Oncological surveillance and early detection of new cancer lesions are also important. PMID: 24614524 [PubMed - in process]
Source: Annals of Transplantation - March 16, 2014 Category: Transplant Surgery Authors: Gozdowska J, Bieniasz M, Wszoła M, Kieszek R, Domagała P, Drozdowski J, Tomaszek A, Kwiatkowski A, Chmura A, Durlik M Tags: Ann Transplant Source Type: research