• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Abstract 1910: Evolution of preleukemia stem cells to lymphoma initiating cells requires thymus in msh2-/- mice
In this study, we use MSH2-/- mice as a model to investigate the existence of PLSC and the evolution of PLSC to LIC. Using bone marrow transplantation, we found that limiting dilutions of MSH2-/- HSCs from young mice are able to reconstitute lethally irradiated wild-type recipients, and contribute to development of multiple hematopoietic lineages. However, all the recipients develop thymic lymphomas after a latency of 3-4 months post transplantation. Transplantation of different fractions of bone marrow cells or thymocytes from young MSH2-/- mice showed that only the HSC enriched fraction leads to lymphoma development. The...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Qing, Y., Gerson, S. L. Tags: Tumor Biology Source Type: research

Determining eligibility for and preparation to kidney transplantation of a patient with Lynch syndrome - a case report and literature review.
Conclusions: The risk of recurrence or new development of cancer related to immunosuppressive treatment should be considered on a case-by-case basis. In patients with a history or high risk of cancer, immunosuppression protocols based on the m-TOR pathway inhibitors should be used, if possible. Oncological surveillance and early detection of new cancer lesions are also important. PMID: 24614524 [PubMed - in process]
Source: Annals of Transplantation - March 16, 2014 Category: Transplant Surgery Authors: Gozdowska J, Bieniasz M, Wszoła M, Kieszek R, Domagała P, Drozdowski J, Tomaszek A, Kwiatkowski A, Chmura A, Durlik M Tags: Ann Transplant Source Type: research