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Lung Cancer in Patients With Lynch Syndrome: Association or Coincidence?
Clin Lung Cancer. 2023 May 31:S1525-7304(23)00109-2. doi: 10.1016/j.cllc.2023.05.007. Online ahead of print.ABSTRACTLynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC) occurs due to microsatellite instability (MSI) caused by mutations in one of the mismatch repair genes leading to deficient mismatch repair proteins (dMMR). Although lung cancer is very common there is no established association between LS and lung cancer. In this manuscript we describe a case of lung cancer in a LS patient and then summarize available literature on this topic. Sixty seven y/o female patient with history of s...
Source: Clinical Colorectal Cancer - June 19, 2023 Category: Cancer & Oncology Authors: Umair Majeed Karan Seegobin Jason Lewis Shenduo Li Yujie Zhao Yanyan Lou Rami Manochakian Source Type: research

Lynch syndrome-associated epithelial ovarian cancer and its immunological profile
CONCLUSION: MMR-d, MSI, and TILs are also seen in Lynch syndrome-associated ovarian cancers making these potential candidates for checkpoint-based immunotherapy. The clinical impact from immune evasion through loss of B2M needs to be investigated further in larger cohorts.PMID:34275654 | DOI:10.1016/j.ygyno.2021.07.001
Source: Gynecologic Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Maria Rasmussen Kevin Lim Eva Rambech Mads Hald Andersen Inge Marie Svane Ove Andersen Lars Henrik Jensen Mef Nilbert Christina Therkildsen Source Type: research

Microsatellite instability in colorectal cancer.
Abstract Microsatellites are short tandem repeat DNA sequences of one to tetra base pairs distributed throughout the human genome, both in coding and non-coding regions. Owing to their repeated structure, microsatellites are particularly prone to replication errors that are normally repaired by the Mismatch Repair (MMR) system. MMR is a very highly conserved cellular process, involving many proteins, resulting in the identification, and subsequent repair of mismatched bases, likely to have arisen during DNA replication, genetic recombination or chemical or physical damage. Proteins within the MMR system include ML...
Source: Acta Bio-Medica : Atenei Parmensis - December 17, 2018 Category: General Medicine Authors: De' Angelis GL, Bottarelli L, Azzoni C, De' Angelis N, Leandro G, Di Mario F, Gaiani F, Negri F Tags: Acta Biomed Source Type: research

Expending Role of Microsatellite Instability in Diagnosis and Treatment of Colorectal Cancers
ConclusionsMany experts and professional authorities have recommended a universal MSI testing in all individuals newly diagnosed with colorectal cancers.
Source: Journal of Gastrointestinal Cancer - July 11, 2017 Category: Cancer & Oncology Source Type: research