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Isolation and Characterization of Chemo-Resistant Stem Cells from a Mouse Model of Hereditary Non-Polyposis Colon Cancer
CONCLUSION: In the present study, a stem cell model for HNPCC was validated and offered a novel experimental approach to test stem cell-targeted alternatives to drug-resistant therapy.PMID:34234468 | PMC:PMC8254583 | DOI:10.2147/SCCAA.S312929
Source: Stem Cells and Cloning: Advances and Applications - July 8, 2021 Category: Stem Cells Authors: Nitin Telang Source Type: research

Abstract 1910: Evolution of preleukemia stem cells to lymphoma initiating cells requires thymus in msh2-/- mice
In this study, we use MSH2-/- mice as a model to investigate the existence of PLSC and the evolution of PLSC to LIC. Using bone marrow transplantation, we found that limiting dilutions of MSH2-/- HSCs from young mice are able to reconstitute lethally irradiated wild-type recipients, and contribute to development of multiple hematopoietic lineages. However, all the recipients develop thymic lymphomas after a latency of 3-4 months post transplantation. Transplantation of different fractions of bone marrow cells or thymocytes from young MSH2-/- mice showed that only the HSC enriched fraction leads to lymphoma development. The...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Qing, Y., Gerson, S. L. Tags: Tumor Biology Source Type: research

Germline deletions in the EPCAM gene as a cause of Lynch syndrome -- literature review.
Abstract Lynch syndrome (clinically referred to as HNPCC -- Hereditary Non-Polyposis Colorectal Cancer) is a frequent, autosomal, dominantly-inherited cancer predisposition syndrome caused by various germline alterations that affect DNA mismatch repair genes, mainly MLH1 and MSH2. Patients inheriting this predisposition are susceptible to colorectal, endometrial and other extracolonic tumors. It has recently been shown that germline deletions of the last few exons of the EPCAM gene are involved in the etiology of Lynch syndrome. Such constitutional mutations lead to subsequent epigenetic silencing of a neighbourin...
Source: Clinical Colorectal Cancer - August 12, 2013 Category: Cancer & Oncology Authors: Tutlewska K, Lubinski J, Kurzawski G Tags: Hered Cancer Clin Pract Source Type: research