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Ethosomal gel for rectal transmucosal delivery of domperidone: design of experiment, < em > in  vitro, < /em > and < em > in  vivo < /em > evaluation
Drug Deliv. 2022 Dec;29(1):1477-1491. doi: 10.1080/10717544.2022.2072542.ABSTRACTDespite high efficiency of domperidone (DOM) in prophylaxis of emesis accompanied with radiotherapy and chemotherapy, it still can bother cancer patients by its powerful side effects and difficulty of its oral administration. The study was designed to develop and optimize DOM loaded ethosomal gel for rectal transmucosal delivery. Ethosomal formulations were prepared using a 21, 51 full-factorial design where the impact of lecithin concentration and additives were investigated. The optimum ethosomal vesicles were subsequently incorporated in Ca...
Source: Drug Delivery - May 11, 2022 Category: Drugs & Pharmacology Authors: Wedad Sakran Rania S Abdel-Rashid Fatma Saleh Raghda Abdel-Monem Source Type: research

Opioid Equianalgesic Tables are Broken
by Drew Rosielle (@drosielle)I am proposing we do away with equianalgesic table (EAT) as a tool to inform clinical decisions about opioid rotations/conversions. Fundamentally, EATs create too many problems, and there are simpler and safer ways to teach clinicians how to convert between different opioids.Part 1: New Data Can ' t Fix the EATA couple HPM fellows every year ask me which table do I prefer to use —the old EAT or the new one? By the old one, they refer to the table most of us used or were at least deeply familiar with for the last 10-20 years. By the new one, they mean the one created by Dr. Mary Lynn McPherson...
Source: Pallimed: A Hospice and Palliative Medicine Blog - March 21, 2022 Category: Palliative Care Tags: opioid pain rosielle Source Type: blogs

Prediction of anastomotic leakage after left-sided colorectal cancer surgery: a pilot study utilizing quantitative near-infrared spectroscopy
ConclusionMonitoring the rSO2 at the anastomotic site enabled the prediction of AL. A prospective study to evaluate the efficacy of the INVOS ™ system for monitoring intestinal rSO2 is in progress.
Source: Surgery Today - January 11, 2022 Category: Surgery Source Type: research

Can Cannabis Help Your Gut?
When Joe Silverman developed Crohn’s disease at age 21, the symptoms started out mild. While the sight of blood in his stools initially freaked him out, what really bothered him was the frequent abdominal pain and bloating that occurred as his condition progressed to moderate and then severe. Dietary changes didn’t make a difference, so he began taking prescription oral anti-inflammatory drugs that are often used to treat certain bowel diseases, which alleviated but didn’t eliminate his discomfort. He started using prescription steroid suppositories to cope with flare-ups of the inflammatory bowel disease...
Source: TIME: Health - September 23, 2021 Category: Consumer Health News Authors: Stacey Colino Tags: Uncategorized Source Type: news

Fecal Transplants: a New Treatment for IBD
Linda Ann Sasser has had ulcerative colitis since she was 20, but it wasn’t until May 2019, about 30 years later, that her condition hit a low point: not only did she have a major flare-up of chronic inflammatory bowel disease (IBD), but on top of it, she had Clostridioides difficile (or C. diff), a highly contagious bacterial infection that causes severe diarrhea and inflammation of the colon. “I became really, really sick with bloody diarrhea 30 times a day and chronic stomach pain,” Sasser says. While hospitalized for 12 days, she was given oral steroid medications, which didn’t help, then IV ste...
Source: TIME: Health - September 9, 2021 Category: Consumer Health News Authors: Stacey Colino Tags: Uncategorized Disease feature Source Type: news

Top Global Health Moments of 2020
By The Editorial Team, IntraHealth International Community Health Nurse Olivia Yeboah thoroughly washes her hands at the Akropong Clinic in Ghana. Photo by Emmanuel Attramah, PMI Impact Malaria/US President ' s Malaria Initiative.December 17, 2020If we wanted to, we could list a COVID-19 moment for every month of 2020.  We all know that the onset of the coronavirus pandemic—first in China and then worldwide—overwhelmed news coverage this year. And with good reason. It’s the first large-scale global pandemic in 100 years. At the time this article was pu...
Source: IntraHealth International - December 17, 2020 Category: International Medicine & Public Health Authors: kseaton Tags: HIV & AIDS COVID-19 Nutrition Policy Advocacy Health Workforce Systems Nursing Midwifery 2020 Health Workers Source Type: news

Diet Rich in Animal Protein Promotes Pro-inflammatory Macrophage Response and Exacerbates Colitis in Mice
In conclusion, we have shown that interactions between dietary protein of animal origin (casein) and gut microbiota increases sensitivity to intestinal inflammation. This pro-inflammatory effect is not dependent on adaptive immunity, but it is driven by activated Ly-6Chi monocytes and subsequent pro-inflammatory tuning of innate immunity. Our results suggest that IBD patients may benefit from changing the source of dietary protein and outline the possibility to use specific antibiotic or probiotic treatment aimed at gut microbiota. Ethics Statement This study was carried out in accordance with the recommendations of the ...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Increased Toxoplasma gondii Intracellular Proliferation in Human Extravillous Trophoblast Cells (HTR8/SVneo Line) Is Sequentially Triggered by MIF, ERK1/2, and COX-2
In conclusion, the present study demonstrated that T. gondii increased MIF production by HTR8/SVneo cells, and it caused CD44 upregulation that activated the ERK 1/2-intracellular signaling pathway, leading to increased COX-2 expression and IL-8 production. In this regard, T. gondii can modulate key factors in HTR8/SVneo cells and this can explain the higher susceptibility of extravillous trophoblast cells to T. gondii infection when compared to other trophoblast cell populations. Data Availability The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservati...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

Lipocalin 24p3 Induction in Colitis Adversely Affects Inflammation and Contributes to Mortality
This study was carried out in accordance with the recommendations of the Case Western Reserve University IACUC committee. The protocol was approved by the Case Western Reserve University IACUC committee. Author Contributions LRD and DW helped design research studies, analyze data and write the manuscript. ZL, RL, and ND conducted experiments, acquired and analyzed data, and assisted with manuscript preparation. LDM conducted experiments and analyzed data. FC assisted with research design. Funding This work was supported by the NIH P30CA043703, K1CA113838, and R01DK081395. Conflict of Interest Statement The authors de...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Hepatoma-Derived Growth Factor and DDX5 Promote Carcinogenesis and Progression of Endometrial Cancer by Activating β-Catenin
Conclusion: Our results provide novel evidence that HDGF interacts with DDX5 and promotes the progression of EC through the induction of β-catenin. Introduction Endometrial cancer (EC) comprises the most common malignancy involving the female genital tract and the fourth most common malignancy in women after breast, lung, and colorectal cancers (1). In 2012, approximately 320,000 new cases of EC were diagnosed worldwide and the incidence is increasing (2). Currently, endometrial carcinogenesis is thought to be a multi-step process involving the coordinated interaction of hormonal regulation, gene mutation, ad...
Source: Frontiers in Oncology - April 10, 2019 Category: Cancer & Oncology Source Type: research

Inhibitory Effect of KP-A038 on Osteoclastogenesis and Inflammatory Bone Loss Is Associated With Downregulation of Blimp1
Conclusion Developing alternative agents that modulate excessive osteoclast formation and bone resorption is an important and urgent task. The results of this study demonstrated that KP-A038 exhibited anti-osteoclastogenic and antiresorptive properties by inhibiting the induction of NFATc1 via modulating the expression of negative regulators of osteoclastogenesis. Furthermore, KP-A038 protected against LPS-induced femoral bone loss in vivo. Our results suggest that KP-A038 might serve as a novel antiresorptive agent for osteoclast-related diseases. Ethics Statement All animal experiments were approved by the Animal Care...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - September 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Understanding Aphasia After Brain Injury
June is National Aphasia Awareness Month, and I wanted to share some of what I have learned on my journey through aphasia after brain injury. According to Wikipedia, the term aphasia implies that one or more communication modalities in the brain have been damaged—and are therefore functioning incorrectly. The difficulties for people with aphasia can range from occasional trouble finding words to losing the ability to speak, read, or write; their intelligence, however, is unaffected. Since no two brain injuries are ever the same, the way aphasia affects one person can vary greatly from the next person. In my own expe...
Source: Healthy Living - The Huffington Post - June 22, 2017 Category: Consumer Health News Source Type: news