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Effects of Sweet Cherry Polyphenols on Enhanced Osteoclastogenesis Associated With Childhood Obesity
Conclusions Our study, to our knowledge, is the first demonstrating in obese children a spontaneous osteoclastogenesis inhibited by polyphenols from sweet cherry extracts, through the reduction of TNFα, without affecting cell viability. We also demonstrated that the spontaneous osteoclastogenesis observed in PBMCs from obese children is supported by the high percentage of circulating CD14+/CD16+ cells and the elevated levels of RANKL and TNFα. Our study opens future perspectives for the use of cherry extracts, appropriately formulated as nutraceuticals as preventive in healthy children and therapeu...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF- β
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcript...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Noonan Syndrome in South Africa: Clinical and Molecular Profiles
Conclusion This first application of targeted NGS for the molecular diagnosis of NS in South Africans suggests that clinical characteristics and genotype-phenotype correlations found in affected individuals are generally similar to those reported in other populations. Therefore, careful phenotyping based on existing diagnostic criteria can effectively enable the diagnosis of most NS-affected individuals in South Africa. The use of targeted NGS in the present study have allowed for detection of novel variants in genes infrequently associated with NS in other populations. Further studies of a larger African cohort with NS, ...
Source: Frontiers in Genetics - April 15, 2019 Category: Genetics & Stem Cells Source Type: research

Measuring Development of Adolescent and Young Adult Cancer Patients: An Integrative Review of Available Instruments.
Abstract Adolescents and young adults (AYAs) 15-39 years old face unique challenges during cancer treatment as developmental and social needs are often disrupted to achieve cure. Developmentally appropriate supportive care for AYAs across the cancer trajectory is needed. The purpose of this review is to identify and describe instruments that measure AYA development across physical, psychological, and social domains, commenting on the instruments' psychometric properties and usefulness in clinical practice and research. A computerized literature search published in English from 1950 to January of 2017 was conducted...
Source: Ann Oncol - February 9, 2018 Category: Cancer & Oncology Authors: Bell CJ, Bell RA, Zebrack B, Kato I, Morse A, Borinstein SC Tags: J Adolesc Young Adult Oncol Source Type: research

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - September 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Minneapolis-Manchester Quality of Life Instrument: reliability and validity of the Adult Form in cancer survivors
ConclusionsThe MMQL-Adult Form is a reliable and valid self-report instrument for measuring multidimensional HRQL in cancer survivors. Development of this instrument ensures availability of a tool enabling cross-sectional and longitudinal assessment of HRQL in childhood cancer survivors as they age.
Source: Quality of Life Research - August 2, 2017 Category: Health Management Source Type: research

Race/Ethnicity, Socioeconomic Status, Residential Segregation, and Spatial Variation in Noise Exposure in the Contiguous United States
Conclusions: We found evidence of racial/ethnic and socioeconomic differences in model-based estimates of noise exposure throughout the United States. Additional research is needed to determine if differences in noise exposure may contribute to health disparities in the United States. https://doi.org/10.1289/EHP898 Received: 01 August 2016 Revised: 06 February 2017 Accepted: 06 February 2017 Published: 25 July 2017 Address correspondence to J.A. Casey, University of California, Berkeley, 13B University Hall, Berkeley, CA 94610 USA. Telephone: 541-760-8477; Email: joanacasey@berkeley.edu Supplemental Material is avail...
Source: EHP Research - July 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls
Conclusion: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. https://doi.org/10.1289/EHP875 Received: 27 July 2016 Revised: 18 January 2017 Accepted: 19 January 2017 Published: 11 July 2017 Address correspondence to E. S. Barrett, Dept. of Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers University School of Public Health, 170 Frelinghuysen Road, Piscataway, NJ 08854...
Source: EHP Research - July 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Clinical Updates, Tips on Business and Billing, Draw Attendees to ASHA Connect
Editor’s note: This is the first of two posts from the ongoing ASHA Connect Conference in Minneapolis. This post focuses on the health care side of the conference. The second, to come on Monday, will focus on the schools side. For speech-language pathologists in private practice and health care, attending ASHA Connect is a slam-dunk: The sessions give them hands-on information they can use right away. The sessions—smaller and more in-depth than those at the ASHA Annual Convention held in November—offer specific clinical strategies and business tips, attendees say. This is the first year for ASHA Connect, which began...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - July 8, 2016 Category: Speech Therapy Authors: Carol Polovoy Tags: Events Speech-Language Pathology Uncategorized Health Care Source Type: blogs

Study: Most People Who Get Melanoma Had Few Moles
By Stacy Simon RESOURCES: Step-by-step skin self-exam instructionsWhat to look for: Images of skin growths People with a lot of moles on their body are thought to be at greater risk for melanoma skin cancer than people with fewer moles or none at all. But according to a study published March 2, 2016 in JAMA Dermatology, most people who get melanoma have few or no moles, so it’s important to pay attention to your skin and perform skin self-exams. According to study author Alan C. Geller, MPH, RN, a senior lecturer at the Harvard TH Chan School of Public Health in Boston, people at highest risk for melanoma incl...
Source: American Cancer Society :: News and Features - March 9, 2016 Category: Cancer & Oncology Tags: Skin Cancer - Melanoma Source Type: news