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Opioid Equianalgesic Tables are Broken
by Drew Rosielle (@drosielle)I am proposing we do away with equianalgesic table (EAT) as a tool to inform clinical decisions about opioid rotations/conversions. Fundamentally, EATs create too many problems, and there are simpler and safer ways to teach clinicians how to convert between different opioids.Part 1: New Data Can ' t Fix the EATA couple HPM fellows every year ask me which table do I prefer to use —the old EAT or the new one? By the old one, they refer to the table most of us used or were at least deeply familiar with for the last 10-20 years. By the new one, they mean the one created by Dr. Mary Lynn McPherson...
Source: Pallimed: A Hospice and Palliative Medicine Blog - March 21, 2022 Category: Palliative Care Tags: opioid pain rosielle Source Type: blogs

A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
Conclusion and Future Directions G protein bias may either be affinity/potency-dominant or efficacy-dominant (Table 1). A potential concern is that, despite using the same cellular assays, variations in agonist potency were determined by different, or even the same labs, potentially due to differences in expression levels of the receptor and signaling proteins that occurred during cell passaging. For example the reported arrestin recruitment potency for U69,593 has been reported to be as low as 67.7 nM (Spetea et al., 2017) and as high as 410 nM (Dunn et al., 2018), similarly for U50,488 potency has ranged from 36 to 1000...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Research brief: Vaccines to treat opioid abuse and prevent fatal overdoses
(University of Minnesota) A team of scientists from the University of Minnesota Medical School and Minneapolis Medical Research Foundation at Hennepin Healthcare is developing vaccines against heroin and prescription opioids, such as oxycodone and fentanyl.
Source: EurekAlert! - Medicine and Health - April 11, 2018 Category: International Medicine & Public Health Source Type: news

Opioids No Better Than Over-The-Counter Pain Meds For Chronic Pain
CBS Local — A yearlong study offers rigorous new evidence against using prescription opioids for chronic pain. In patients with stubborn back aches or hip or knee arthritis, opioids worked no better than over-the-counter drugs or other nonopioids at reducing problems with walking or sleeping. They also provided slightly less pain relief. Opioids tested included generic Vicodin, oxycodone or fentanyl patches although few patients needed the most potent opioids. Nonopioids included generic Tylenol, ibuprofen, and prescription pills for nerve or muscle pain. The study randomly assigned patients to take opioids or other ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - March 7, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Addiction Chris Melore Local TV opioid crisis opioids Painkillers talkers Tylenol Source Type: news

Newly Unsealed Documents Highlight Prince's Struggle with Opioids
Before his death, Prince abused opioid pain pills, suffered withdrawal symptoms and received at least one opioid prescription under his bodyguard's name, according to search warrants and affidavits unsealed Monday. Prince was 57 when he was found alone and unresponsive in an elevator at Paisley Park on April 21. Nearly a year after his accidental overdose death at his suburban Minneapolis studio and estate, investigators still don't know how he got the fentanyl that killed him. The newly unsealed documents give the clearest picture yet of Prince's struggle with opioid painkillers. What Do Authorities Say Happened? Investig...
Source: JEMS: Journal of Emergency Medical Services News - April 18, 2017 Category: Emergency Medicine Authors: CARLA K. JOHNSON, AP Medical Writer Tags: Patient Care News Source Type: news

Death after use of recreational marijuana, and other Tox on the Web
More on e-cigarette nicotine liquid: On KSTP-TV news in Minneapolis/St. Paul, medical toxicologist Dr. Ben Orozco discusses the hazards of e-cigarette refill liquid, and the signs and symptoms of nicotine toxicity. Suicide by hydrogen sulfide: The St. Charles (LA) Herald-Guide reported the tragic story about a 32-year-old research scientist who killed herself by releasing hydrogen sulfide in her car. She had posted hazmat warnings in the windows to protect first responders. TPR has written previously about these s0-called “chemical suicides,” a phenomenon that started in Japan and often takes place in the v...
Source: The Poison Review - April 8, 2014 Category: Toxicology Authors: Leon Tags: Medical ADHD driving e-cigarette fluoroquinonlone adverse effects hydrogen sulfide magic mushroom marijuana marijuana death motor vehicle collisions nicotine opiates opioids poison ivy poison oak psilocybin suicide traffi Source Type: news