• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Increased Toxoplasma gondii Intracellular Proliferation in Human Extravillous Trophoblast Cells (HTR8/SVneo Line) Is Sequentially Triggered by MIF, ERK1/2, and COX-2
In conclusion, the present study demonstrated that T. gondii increased MIF production by HTR8/SVneo cells, and it caused CD44 upregulation that activated the ERK 1/2-intracellular signaling pathway, leading to increased COX-2 expression and IL-8 production. In this regard, T. gondii can modulate key factors in HTR8/SVneo cells and this can explain the higher susceptibility of extravillous trophoblast cells to T. gondii infection when compared to other trophoblast cell populations. Data Availability The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservati...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

Inhibitory Effect of KP-A038 on Osteoclastogenesis and Inflammatory Bone Loss Is Associated With Downregulation of Blimp1
Conclusion Developing alternative agents that modulate excessive osteoclast formation and bone resorption is an important and urgent task. The results of this study demonstrated that KP-A038 exhibited anti-osteoclastogenic and antiresorptive properties by inhibiting the induction of NFATc1 via modulating the expression of negative regulators of osteoclastogenesis. Furthermore, KP-A038 protected against LPS-induced femoral bone loss in vivo. Our results suggest that KP-A038 might serve as a novel antiresorptive agent for osteoclast-related diseases. Ethics Statement All animal experiments were approved by the Animal Care...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Molecular and Physiological Characterization of Fluoroquinolone-Highly Resistant Salmonella Enteritidis Strains
This study provides two important novel findings. The first, the deletions in the ramRA region, affecting the RamR binding site, and the amino acid substitution at position 87 of the GyrA are mutations significantly associated with the highly resistant S. Enteritidis strains, clearly illustrating their importance in conferring a high level of FQs resistance. The second, the deletion in the intergenic region of the ramRA operon provides resistance and reduced susceptibility to several antibiotics, including, ceftiofur, amoxicillin/clavulanic acid, azithromycin and tetracycline. Collectively, our study suggests complex inter...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Notes from the Field: Outbreaks of Shigella sonnei Infection with Decreased Susceptibility to Azithromycin Among Men Who Have Sex with Men — Chicago and Metropolitan Minneapolis-St. Paul, 2014
Source: CDC Morbidity and Mortality Weekly Report - June 5, 2015 Category: American Health Source Type: news

Notes from the Field: Outbreaks of Shigella sonnei Infection with Decreased Susceptibility to Azithromycin Among Men Who Have Sex with Men - Chicago and Metropolitan Minneapolis-St. Paul, 2014.
This report summarizes and compares the findings from investigations of the two outbreaks, which occurred among MSM in metropolitan Minneapolis-St. Paul, Minnesota, and Chicago, Illinois. PMID: 26042652 [PubMed - in process]
Source: MMWR Morb Mortal Wkl... - June 5, 2015 Category: Epidemiology Authors: Bowen A, Eikmeier D, Talley P, Siston A, Smith S, Hurd J, Smith K, Leano F, Bicknese A, Norton JC, Campbell D Tags: MMWR Morb Mortal Wkly Rep Source Type: research