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Evaluation of a Geographic Screening Protocol for Chronic Parasitic Infections Before Kidney Transplant: An Institutional Experience in Minnesota
Am J Trop Med Hyg. 2022 Nov 14;107(5):1041-1046. doi: 10.4269/ajtmh.22-0413. Print 2022 Nov 14.ABSTRACTPretransplant recommendations advise risk-based screening for strongyloidiasis, schistosomiasis, and Chagas disease. We evaluated the implementation of a chronic parasite screening protocol at a health system in a nonendemic region serving a large foreign-born population. Candidates listed for kidney transplant at Hennepin Healthcare (Minneapolis, MN) between 2010 and 2020 were included. Country of birth and serologic screening for strongyloidiasis, schistosomiasis, and Chagas disease were retrospectively obtained from el...
Source: The American Journal of Tropical Medicine and Hygiene - November 17, 2022 Category: Tropical Medicine Authors: Christine M Thomas Jessica Butts Jennifer Czachura Altair Alonso Kevin Reininger Megan K Shaughnessy Source Type: research

Precision Health for Chagas Disease: Integrating Parasite and Host Factors to Predict Outcome of Infection and Response to Therapy
Chagas disease, caused by the infection with the protozoan parasite Trypanosoma cruzi, is clinically manifested in approximately one-third of infected people by inflammatory heart disease (cardiomyopathy) and, to a minor degree, gastrointestinal tract disorders (megaesophagus or megacolon). Chagas disease is a zoonosis transmitted among animals and people through the contact with triatomine bugs, which are found in much of the western hemisphere, including most countries of North, Central and South America, between parallels 45° north (Minneapolis, USA) and south (Chubut Province, Argentina). Despite much research on drug...
Source: Frontiers in cellular and infection microbiology - May 7, 2020 Category: Microbiology Source Type: research

Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes
Conclusion: ROS promote CD8+ T cell activation by facilitating autoantigen cross-presentation by DCs. ROS scavengers could potentially represent an important component of therapies aiming to disrupt autoantigen presentation and activation of CD8+ T cells in individuals at-risk for developing T1D. In Type 1 Diabetes (T1D), pancreatic β cells are attacked by a T cell mediated autoimmune response and lose their ability to produce insulin (1–3). While a number of immune cell subsets are involved throughout the development of T1D, cytotoxic CD8+ T cells (CTLs) function as primary effectors of ...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Increased Toxoplasma gondii Intracellular Proliferation in Human Extravillous Trophoblast Cells (HTR8/SVneo Line) Is Sequentially Triggered by MIF, ERK1/2, and COX-2
In conclusion, the present study demonstrated that T. gondii increased MIF production by HTR8/SVneo cells, and it caused CD44 upregulation that activated the ERK 1/2-intracellular signaling pathway, leading to increased COX-2 expression and IL-8 production. In this regard, T. gondii can modulate key factors in HTR8/SVneo cells and this can explain the higher susceptibility of extravillous trophoblast cells to T. gondii infection when compared to other trophoblast cell populations. Data Availability The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservati...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

Autophagy Limits Inflammasome During Chlamydia pneumoniae Infection
In this study we found blocking autophagy led to increased CP growth in both macrophages and mouse embryonic fibroblasts. In vivo, loss of the autophagy elongation component ATG16L1 specifically in myeloid cells led to increased mortality in response to CP infection, characterized by greater numbers of neutrophils and dendritic cells, but no change in the CP burden in the lungs. This was accompanied by an increase in inflammasome-active macrophages and IL-1β production. While induction of autophagy in macrophages led to reduced CP growth in vitro, in vivo treatment with rapamycin led to increased mortality of infec...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Minnesota Boy Dies From Brain Infection After Swimming In Lake
MINNEAPOLIS (AP) -- A 14-year-old boy who developed a rare brain infection after swimming in a Minnesota lake died Thursday, his family said in a statement as health officials worked to determine whether it was caused by a water parasite that's more common in warmer southern states. The family of Hunter Boutain, of Alexandria, made the announcement in a statement issued through the University of Minnesota Medical Center, where he died. "Hunter's condition deteriorated throughout the night and he was declared brain dead this morning," his uncle and family spokesman, Brian Boutain, said in the statement. "Hunter died surroun...
Source: Healthy Living - The Huffington Post - July 10, 2015 Category: Consumer Health News Source Type: news

Climate Change and Disease: USA Today Gets It Wrong
This report describes statistically significant increases in the incidence rate of reported coccidioidomycosis in endemic states during 1998–2011 after adjusting for changes in population size and in age and sex distribution. Although the number of cases decreased in Arizona during 2007–2008 and in California during 2007–2009, incidence dramatically increased in 2010 and 2011. In 2011, coccidioidomycosis was the second most commonly reported nationally notifiable condition in Arizona and the fourth most commonly reported in California. The reasons for the increases described in this report are unclear. Coccidioides e...
Source: Cato-at-liberty - December 16, 2013 Category: Health Medicine and Bioethics Commentators Authors: Patrick J. Michaels, Paul C. "Chip" Knappenberger Source Type: blogs

End of life numbers (as we know it)
Life as we once knew it here in the west is being brought to a close by our criminal in chief his handlers and the rest of the luciferian crew, but nobody cares so who gives a rat's ass except for a small cadre of those with traditional morals and values. I have been running into a number of other watchmen; something BIG is coming up over the horizon, and it's not santa claus. Here's another big list of placed of interest (to me anyway) and again I do not buy into the content of each and every site I link to, but most have a lot of truth to reveal, much more so than you'll ever get from the corporate MSM 10 Reasons...
Source: Nightmare Hall - Welcome to my nightmare - September 16, 2013 Category: HIV AIDS Source Type: blogs