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Total 3164 results found since Jan 2013.
Dopamine Receptor 1 Impedes ILC2-Mediated Antitumor Immunity
In this study, we report that dopamine receptor 1 (DRD1) restrains ILC2 activity in the TME. DRD1 deficiency promotes ILC2 activation, which irritates eosinophil recruitment and cytotoxic CD8+ T cell expansion during ongoing malignancy. Consequently, DRD1-deficient mice exhibit delayed tumor growth and reduced tumor progression. Furthermore, fenoldopam, a selective DRD1 agonist, restrains the ILC2 response in the TME and aggravates tumor burden in mice. Taken together, our data elaborate that the DRD1 signal acts as an excitatory rheostat in regulating ILC2-dependent antitumor immunity.PMID:37728417 | DOI:10.4049/jimmunol.2300220
Source: Journal of Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Xiangyang Wang Xiangyu Chen Jierong Chen Chunhui Liao Xiaofan Yang Jiasheng Zhou Shanshan Liu Shusen Ye Yuhao Zheng Linzi Huang Jiacong Zhao Lilin Ye Bihui Huang Yingjiao Cao Source Type: research
Cancers, Vol. 15, Pages 4619: Repurposing Clemastine to Target Glioblastoma Cell Stemness
hristopher J. Pirozzi
Yiping He
Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the stemness and suppressed the propagation of primary BTIC cultures bearing PDGFRA amplification. These effects on BTICs were accompanied by altered gene expression profiling indicative of their more differentiated states, resonating with the activity of clemastine in promoting the differentiation of normal oligodendrocyte progenitor cells (OPCs) into mat...
Source: Cancers - September 18, 2023 Category: Cancer & Oncology Authors: Michael A. Sun Rui Yang Heng Liu Wenzhe Wang Xiao Song Bo Hu Nathan Reynolds Kristen Roso Lee H. Chen Paula K. Greer Stephen T. Keir Roger E. McLendon Shi-Yuan Cheng Darell D. Bigner David M. Ashley Christopher J. Pirozzi Yiping He Tags: Article Source Type: research
Acquired angioedema due to C1-inhibitor-deficiency (AAE-C1-INH) - a bi-center retrospective study on diagnosis, course and therapy
CONCLUSION: AAE-C1-INH is characterized by late onset swellings mainly involving the face and low C1-INH levels. Diagnostic delay for AAE-C1-INH is further decreasing despite being about 10-fold rarer than HAE. Patients severely affected without underlying condition or no indication for treatment could benefit from off-label therapy.PMID:37716525 | DOI:10.1016/j.jaip.2023.09.003
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Felix Johnson Janina Hahn Benedikt Hofauer Jens Greve Barbara Wollenberg Thomas K Hoffmann Robin Lochbaum Susanne Trainotti Source Type: research
The Influence of Sex Hormones and X Chromosome in Immune Responses
Curr Top Microbiol Immunol. 2023;441:21-59. doi: 10.1007/978-3-031-35139-6_2.ABSTRACTMales and females differ in their susceptibility to develop autoimmunity and allergy but also in their capacity to cope with infections and cancers. Cellular targets and molecular pathways underlying sexual dimorphism in immunity have started to emerge and appeared multifactorial. It became increasingly clear that sex-linked biological factors have important impact on the development, tissue maintenance and effector function acquisition of distinct immune cell populations, thereby regulating multiple layers of innate or adaptive immunity t...
Source: Current Topics in Microbiology and Immunology - September 11, 2023 Category: Microbiology Authors: Nina Anesi Charles-Henry Miquel Sophie Laffont Jean-Charles Gu éry Source Type: research
Inhibition of Interleukin-6 Dependent Metalloproteinases-9/2 Expression in Cancer Cells by Diet Polyphenols
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - September 7, 2023 Category: Allergy & Immunology Authors: Arcone, Rosaria Nasso, Rosarita Pagliara, Valentina D ' Errico, Antonio Motti, Maria L. D ' Angelo, Stefania Carbonara, Gabriele Masullo, Mariorosario Tags: Review article Source Type: research
Device-assisted intravesical chemotherapy versus bacillus Calmette –Guerin for intermediate or high-risk non-muscle invasive bladder cancer: a systematic reviewer and meta-analysis
ConclusionDevice-assisted intravesical chemotherapy appears to be a safe and viable alternative to BCG for patients with intermediate and high-risk NMIBC, showing comparable oncological outcomes and adverse events.
Source: International Urology and Nephrology - September 2, 2023 Category: Urology & Nephrology Source Type: research
One in Five Men Are Carriers of High-Risk HPV One in Five Men Are Carriers of High-Risk HPV
Estimates based on a recent literature review lend further weight to arguments in favor of vaccinating boys against HPV to prevent certain types of cancer.Medscape Medical News
Source: Medscape Allergy Headlines - August 31, 2023 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
