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Cancer: Epithelial Cancer
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Total 214 results found since Jan 2013.
Genome-wide Epigenetic Study of Chronic Rhinosinusitis Tissues Reveals Dysregulated Inflammatory, Immunologic and Remodeling Pathways
CONCLUSIONS: Differential patterns of methylation were identified between controls and CRS, CRSwNP, and CRSsNP. Epigenetic, environmentally-induced changes related to novel, inflammatory, immunologic, and remodeling pathways appear to affect epithelial integrity, cell proliferation, homeostasis, vascular permeability, and other yet uncharacterized pathways and genes.PMID:37584357 | DOI:10.1177/19458924231193526
Source: American Journal of Rhinology and Allergy - August 16, 2023 Category: ENT & OMF Authors: Tripti Brar Saurabh Baheti Michael J Marino Hirohito Kita Devyani Lal Source Type: research
A Metagenomic Analysis of the Virome of Inverted Papilloma and Squamous Cell Carcinoma
ConclusionsThere are over 200 HPV types that infect human epithelial cells, of which only a few are known to be high-risk. Our study demonstrated a trend of increasing prevalence of HPV18-E6 that correlated with histologic severity, which is novel and supports a potential role for HPV in the pathogenesis of IP.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - May 16, 2023 Category: Allergy & Immunology Authors: Charles C. L. Tong,
Xiang Lin,
Tyler Seckar,
Mateusz Koptyra,
Michael A. Kohanski,
Noam A. Cohen,
David W. Kennedy,
Nithin D. Adappa,
Peter Papagiannopoulos,
Edward C. Kuan,
Esther Baranov,
Jalal B. Jalaly,
Michael D. Feldman,
Phillip B. Stor Tags: ORIGINAL ARTICLE Source Type: research
MicroRNA-122 Is More Effective than Rapamycin in Inhibition of Epithelial-mesenchymal Transition and mTOR Signaling Pathway in Triple Negative Breast Cancer
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):46-61. doi: 10.18502/ijaai.v22i1.12006.ABSTRACTThe fundamental mechanism responsible for the aggressiveness of metastatic cancers such as triple-negative breast cancer (TNBC) is the epithelial-mesenchymal transition (EMT). In cancer microenvironments, the Phosphoinositide 3-kinases (PI3K)-Akt- mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating the EMT mechanism. The current study focuses on the impacts of rapamycin, a newly retargeted chemotherapeutic agent against mTOR, and MicroRNA (miR)-122 on the aggressive behavior of TNBC. The ha...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Majdedin Ghalavand Ruhollah Dorostkar Hojat Borna Samira Mohammadi-Yeganeh Seyed Mahmood Hashemi Source Type: research
