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Total 198 results found since Jan 2013.
Evaluation of Molecular-level Changes of Programmed Cell Death Ligand-1 after Radiation Therapy in a BALB/c CT26 Colorectal Mouse Tumor Model
In this study, female BALB/c mice inoculated with CT26 tumor cells were irradiated with 3 different RT regimens using the same BED of 40 gray (Gy). These included ablative RT (1*15 Gy), hypo-fractionated RT (2*10 Gy), and conventional (Hyper-fractionated) RT (10*3 Gy). PD-L1 expression was analyzed with immunohistochemical staining on days 2 and 20 and when the size of tumors had reached 2 cm2 after RT. All treated groups expressed PD-L1, but the group receiving single ablative high-dose RT showed higher expression compared to the other groups. No significant differences in PD-L1 expression were observed at different times...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Fateme Khani Chamani Mahdi Shabani Afshin Moradi Maedeh Alinejad Seyed Amir Jalali Source Type: research
Examination of colorectal cancer cases with metal allergy
ConclusionThe patch test is useful for selecting an optimal anastomosis method for patients with suspected metal allergy.
Source: Surgery Today - June 26, 2023 Category: Surgery Source Type: research
New STELARA ® (ustekinumab) Long-Term Data Support its Established Safety Profile in Inflammatory Bowel Disease and Durable Efficacy in Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, March 4, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced final pooled long-term safety results for STELARA® (ustekinumab) through five years in adults with moderately to severely active Crohn’s disease (CD) and four years in adults with moderately to severely active ulcerative colitis (UC), as well as final four-year clinical and endoscopic outcomes from the UNIFI long-term extension (LTE) study evaluating the efficacy of STELARA for the treatment of adults with moderately to severely active UC.1,2 These data are a part of Janssen’s 22 oral and poster ...
Source: Johnson and Johnson - March 4, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news
Examination of colorectal cancer cases with metal allergy
CONCLUSION: The patch test is useful for selecting an optimal anastomosis method for patients with suspected metal allergy.PMID:36757618 | DOI:10.1007/s00595-023-02643-7
Source: Hand Surgery - February 9, 2023 Category: Surgery Authors: Kosuke Mizukoshi Yu Okazawa Kota Amemiya Yuki Tsuchiya Shunsuke Motegi Ryoichi Tsukamoto Kumpei Honjo Rina Takahashi Nagisa Yoshihara Shingo Kawano Masaya Kawai Shinya Munakata Shun Ishiyama Kiichi Sugimoto Makoto Takahashi Yutaka Kojima Shigaku Ikeda Kaz Source Type: research
< em > Dolomiaea costus: < /em > an untapped mine of sesquiterpene lactones with wide magnificent biological activities
Nat Prod Res. 2023 Jan 10:1-11. doi: 10.1080/14786419.2022.2164577. Online ahead of print.ABSTRACTDolomiaea costus (Falc.) Kasana & A.K. Pandey Family Asteraceae, formerly known as Saussurea costus (Falc.) Lipsch contains a rich treasury of diverse bioactive compounds such as monoterpenes, sesquiterpenes, triterpenes, sterols, cardenolides, flavonoids, coumarins, lignans, phenylpropanoids and alkaloids. The sesquiterpene lactones, costunolide and dehydrocostuslactone in D. costus, possess unique promising in vitro and in vivo biological activities for the prevention and cure of diverse ailments like Parkinson's disease...
Source: Natural Product Research - January 10, 2023 Category: Biochemistry Authors: Ebraheem Abouelwafa Amal Zaki Omar M Sabry Giovanni Caprioli Essam Abdel-Sattar Source Type: research
Tiny implantable device designed by UCLA scientists helps kill cancer
Many solid tumors resist treatment in part by turning human biology against itself. Tumors surround themselves with extra white blood cells known as regulatory T cells, which call off the body ’s natural defenses against the disease.Strategies to treat cancer by deactivating these cells risk creating other serious problems. Since regulatory T cells play an important role in safeguarding healthy tissues, diminishing them throughout the body can lead to other immune cells mistakenly attacking these tissues and causing autoimmune conditions that damage the colon, liver, heart and other organs.Now, an interdisciplinary UCLA ...
Source: UCLA Newsroom: Health Sciences - January 4, 2023 Category: Universities & Medical Training Source Type: news
What Causes Bloating —and What to Do About It
Bloating is an uncomfortable feeling of fullness or pressure in the abdomen. Like an overinflated balloon, a bloated belly can feel packed with air, and in some cases may be visibly enlarged or distended.
Bloating is a common issue. By some estimates, up to 30% of Americans experience it from time to time. In a majority of cases, the sensation is temporary and tolerable. It may not be pleasant, but on its own it’s usually not cause for serious concern. However, bloating can also be a symptom of an underlying gastrointestinal problem or disorder, including some issues that warrant a medical provider’s urgent att...
Source: TIME: Health - January 4, 2023 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Gut health healthscienceclimate Source Type: news
Hypersensitivity reactions to folinic acid: mechanisms involved based on two case reports and a literature review
Allergy Asthma Clin Immunol. 2022 Dec 22;18(1):107. doi: 10.1186/s13223-022-00752-5.NO ABSTRACTPMID:36550565 | DOI:10.1186/s13223-022-00752-5
Source: Clinical Colorectal Cancer - December 22, 2022 Category: Cancer & Oncology Authors: Matve ï Apraxine Marc Van den Eynde Astrid De Cuyper Fran çoise Pirson Source Type: research
Biallelic TLR4 deficiency in humans
J Allergy Clin Immunol. 2022 Nov 23:S0091-6749(22)01373-2. doi: 10.1016/j.jaci.2022.08.030. Online ahead of print.NO ABSTRACTPMID:36462956 | DOI:10.1016/j.jaci.2022.08.030
Source: Clinical Colorectal Cancer - December 3, 2022 Category: Cancer & Oncology Authors: Melania Capitani Ahmad A Al-Shaibi Sumeet Pandey Lisa Gartner Henry Taylor Satanay Z Hubrack Nourhen Agrebi Muneera Jassim Al-Mohannadi Saad Al Kaabi Thomas Vogl Johannes Roth Daniel Kotlarz Christoph Klein Adrian K Charles Vinayan Vijayakumar Mohammed Yo Source Type: research
