Filtered By:
Cancer: Acute Leukemia

This page shows you your search results in order of date.

Order by Relevance | Date

Total 146 results found since Jan 2013.

Hereditary angioedema with an acute attack resolved after bone marrow transplantation for acute myeloid leukemia: a case report
Hereditary angioedema (HAE), which is caused by C1-inhibitor (C1-INH) deficiency or dysfunction, is a rare and potentially life-threatening disease. In patients with HAE, excess production of bradykinin causes...
Source: Allergy, Asthma and Clinical Immunology - May 16, 2023 Category: Allergy & Immunology Authors: Daisuke Honda, Isao Ohsawa, Masashi Aizawa, Yasuhiko Tomino and Katsuhiko Asanuma Tags: Case report Source Type: research

Cancers, Vol. 15, Pages 1829: Associations of T-Cell Receptor Repertoire Diversity with L-Asparaginase Allergy in Childhood Acute Lymphoblastic Leukemia
Yang Allen E. J. Yeoh Asparaginase is a critical component of therapy for childhood acute lymphoblastic leukemia (ALL), but it is commonly associated with allergy, which results in morbidity and poorer outcomes. The underlying basis of this allergy is undoubtedly immune-mediated, but the exact components of T-cell immunity have yet to be characterized. We performed longitudinal TCR sequencing of 180 bone marrow samples from 67 children with B-ALL treated as part of the Ma-Spore-ALL-2010 trial, and we evaluated the associations of TCR profile with asparaginase hypersensitivity, with functional validation of asparagina...
Source: Cancers - March 17, 2023 Category: Cancer & Oncology Authors: Shawn H. R. Lee Zhenhua Li Evelyn H. Z. Lim Winnie H. N. Chin Nan Jiang Kean Hui Chiew Zhiwei Chen Bernice L. Z. Oh Ah Moy Tan Hany Ariffin Jun J. Yang Allen E. J. Yeoh Tags: Article Source Type: research

Multiple Reactions and Increased Infusion Time During Desensitization May Decrease the Efficacy of Pegaspargase Chemotherapy
Asparaginase therapy improves survival in Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma and is considered a critical component of chemotherapy. However, 10-25% of patients experience immediate hypersensitivity reactions to the preferred asparaginase chemotherapeutic agent, pegaspargase. In the setting of limited supply of the main alternative agent, Erwinia asparaginase, patients may not be able to receive asparaginase therapy unless they undergo desensitization. While cases of successful desensitizations to pegaspargase have been described, our center ’s experience has demonstrated challenges in effectively de...
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Elizabeth Gilje, Christine Cho, Laura Ann Wang Source Type: research

Two cases of eosinophilic gastrointestinal disorder due to newly appearing food allergies after cord blood transplantation
Transpl Immunol. 2023 Jan 2;77:101781. doi: 10.1016/j.trim.2022.101781. Online ahead of print.ABSTRACTEosinophilic gastrointestinal disorders (EGIDs) are infrequent complications after allogeneic hematopoietic cell transplantation (allo-HCT). Furthermore, it is well-known that allergic diseases are transferable after allo-HCT from allergic donors to non-allergic recipients. However, the type of graft-versus host disease (GVHD) prophylaxis that leads to allergic disease transfer is unclear. Furthermore, no study has reported a case of acquired food allergy resulting in EGID that was detected based on the clinical course and...
Source: Transplant Immunology - January 5, 2023 Category: Transplant Surgery Authors: Naonori Harada Yosuke Makuuchi Masatomo Kuno Teruhito Takakuwa Hiroshi Okamura Mitsutaka Nishimoto Yasuhiro Nakashima Hideo Koh Miho Sakaida Sayaka Tanaka Yuko Kuwae Akira Higashimori Fumino Tanaka Masahiko Ohsawa Yasuhiro Fujiwara Masayuki Hino Hirohisa Source Type: research

A unique presentation of gata2 deficiency, emberger syndrome
GATA2 deficiency is a genetic defect resulting in a group of disorders, including Emberger syndrome. It presents in childhood with lymphedema, sensorineural hearing loss, lymphocyte deficiency, pulmonary alveolar proteinosis, and one or more dysplasias, commonly myelodysplastic syndrome or acute myeloid leukemia.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: O. Yamak, P. Poowuttikul, A. Navalpakam Tags: M235 Source Type: research

ALL-079 Association of T-Cell Receptor Repertoire Diversity With L-Asparaginase Hypersensitivity in Childhood Acute Lymphoblastic Leukemia
Context: Asparaginase is an indispensable component of therapy for childhood acute lymphoblastic leukemia (ALL) but is very commonly associated with allergy which causes morbidity and poorer outcomes. The exact aspects of T-cell immunity underpinning association with asparaginase allergy has yet to be characterized. Objective: To evaluate the associations of T-cell receptor (TCR) repertoire and its diversity with asparaginase hypersensitivity in children with ALL. Design: Longitudinal TCR-sequencing of 180 bone marrow samples across 3 time-points (diagnosis, post-induction, post-consolidation) from 67 children with ALL tre...
Source: Clinical Lymphoma, Myeloma and Leukemia - September 21, 2022 Category: Hematology Authors: Shawn HR Lee, Zhenhua Li, Evelyn HZ Lim, Winnie HN Chin, Chiew Kean Hui, Chen Zhi Wei, Bernice LZ Oh, Ah Moy Tan, Hany Ariffin, Jun J Yang, Allen EJ Yeoh Tags: Acute Lymphoblastic Leukemia Source Type: research

AML ' s Seasonal Peak Suggests Viral or Environmental Etiology AML ' s Seasonal Peak Suggests Viral or Environmental Etiology
The finding that most diagnoses of acute myeloid leukemia are made during January raises the possibility that the cancer results from infectious or environmental agents.Medscape Medical News
Source: Medscape Allergy Headlines - August 16, 2022 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

The Effects of PI3K/Akt/mTOR Signaling Pathway Inhibitors on the Expression of Immune Checkpoint Ligands in Acute Myeloid Leukemia Cell Line
Iran J Allergy Asthma Immunol. 2022 Apr 11;21(2):178-188. doi: 10.18502/ijaai.v21i2.9225.ABSTRACTUp-regulation of immune checkpoint ligands is considered as one of the most important immune escape mechanisms in acute myeloid leukemia (AML). Herein, we investigate a relationship between the inhibition of PI3K/Akt/mTOR signaling pathways and the regulation of immune checkpoint ligands in AML cells. The HL-60 cell line was treated with idelalisib as PI3K inhibitor, MK-2206 as Akt inhibitor, and everolimus as mTOR inhibitor either in a single or combined format. Cell viability and apoptosis were evaluated using MTT and flow cy...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 1, 2022 Category: Allergy & Immunology Authors: Saeid Taghiloo Saeid Norozi Hossein Asgarian-Omran Source Type: research

What Are Some Mast Cell Disorders?
Discussion Mast cells (MCs) were first discovered by Paul Ehrlich in 1878. Previously in 1869, Nettleship and Tay described a toddler with chronic urticaria and a brown skin lesion which is believed to be the first reported case of mastocytosis. Urticaria pigmentosa was a term first used by Sangster in 1878, and in 1936 the term mastocytosis was used. “Mast cells first evolved 500 million years ago in Ascidians (sea squirts), providing host innate immunity against bacteria and parasites….MCs gained additional functions regulating inflammation, wound healing, coagulation, adaptive immunity and acute allergic res...
Source: PediatricEducation.org - February 21, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

COVID-19 mRNA Vaccination Appears Safe in Pediatric Patients With A Hypersensitivity Reaction To PEGylated Escherichia Coli L-Asparaginase
L-Asparaginase is an established component of acute leukemia therapy. PEG-asparaginase (PEGAsp), Escheria coli L-asparaginase linked to polyethylene glycol (PEG), is a common first-line formulation. However, PEGAsp hypersensitivity occurs in 10-15% of patients, with the PEG component most commonly suggested [PCA1] antigenic culprit. Because mRNA COVID-19 vaccines contain PEG, albeit of a different molecular weight, administration safety in patients with prior PEGAsp hypersensitivity has been questioned.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Nicole Wolfset, Charles Phillips, Madison Stein, Susan Rheingold, Jennifer Heimall, Caitlin Elgarten Source Type: research