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Total 571 results found since Jan 2013.

Consensus of an ACAAI, AAAAI, and ATS Workgroup on Definition of Clinical Remission in Asthma on Treatment
Ann Allergy Asthma Immunol. 2023 Sep 8:S1081-1206(23)01218-8. doi: 10.1016/j.anai.2023.08.609. Online ahead of print.NO ABSTRACTPMID:37690606 | DOI:10.1016/j.anai.2023.08.609
Source: Annals of Allergy, Asthma and Immunology - September 10, 2023 Category: Allergy & Immunology Authors: Michael Blaiss John Oppenheimer Mark Corbett Len Bacharier Jonathan Bernstein Tara Carr Bradley Chipps Simon Couillard Erick Forno Torie Grant Njira Lugogo Kathleen May Eric Schauberger Source Type: research

Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis
CONCLUSION Autoreactive, proinflammatory CD4+ T cells and autoantibodies develop to ECM proteins in a subgroup of postinfectious LA patients who have specific HLA-DR alleles. Rather than the traditional molecular mimicry model, we propose that epitope spreading provides the best explanation for this example of infection-induced autoimmunity.FUNDING Supported by National Institute of Allergy and Infectious Diseases R01-AI101175, R01-AI144365, and F32-AI125764; National Institute of Arthritis and Musculoskeletal and Skin Diseases K01-AR062098 and T32-AR007258; NIH grants P41-GM104603, R24-GM134210, S10-RR020946, S10-OD010724...
Source: Journal of Clinical Investigation - September 1, 2023 Category: Biomedical Science Authors: Korawit Kanjana, Klemen Strle, Robert B. Lochhead, Annalisa Pianta, Laura M. Mateyka, Qi Wang, Sheila L. Arvikar, David E. Kling, Cameron A. Deangelo, Lucy Curham, Alan G. Barbour, Catherine E. Costello, James J. Moon, Allen C. Steere Source Type: research

A phase II study of Bruton’s tyrosine kinase inhibition for the prevention of anaphylaxis
CONCLUSION Acalabrutinib pretreatment achieved clinically relevant increases in patients’ tolerance to their food allergen, thereby supporting the need for larger, placebo-controlled trials.TRIAL REGISTRATION ClinicalTrials.gov NCT05038904FUNDING AstraZeneca Pharmaceuticals, the Johns Hopkins Institute for Clinical and Translational Research, the Ludwig Family Foundation, and NIH grants AI143965 and AI106043.
Source: Journal of Clinical Investigation - August 15, 2023 Category: Biomedical Science Authors: Ragha V. Suresh, Collin Dunnam, Dhananjay Vaidya, Robert A. Wood, Bruce S. Bochner, Donald W. MacGlashan Jr., Melanie C. Dispenza Source Type: research

O-058 PPODA as a mechanically stable and biocompatible coating for endovascular stents and flow diverters
ConclusionPPODA polymer coatings can improve biocompatibility and prevent thrombosis on FDs and stents by pre-coating wires for braiding or post-coating laser-cut stent devices. Future work will compare coating integrity and biocompatibility to established devices (i.e Pipeline Shield® and Fred-X®). Materials like PPODA may provide FDs and stents with a mechanically stable scaffold coating that promotes continuous re-endothelialization over an aneurysm neck, which can eliminate thrombosis and reduce recanalization rates.Abstract O-058 Figure 1SH-PEG-Silane and PPODA bound to a nitinol wire surface. Figure la is an ...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Robertson, S., Merritt, W., Becker, T., Ducruet, A. Tags: SNIS 20th annual meeting oral abstracts Source Type: research

Explainer: Why the U.S. has banned funding for Chinese lab at center of pandemic origin dispute
In a move that has more symbolic than practical impact, the U.S. Department of Health and Human Services (HHS) has imposed new sanctions on a Chinese lab at the center of the debate about the origin of the COVID-19 pandemic. A nine-page HHS memo made public by a House subcommittee that ’s investigating the pandemic ’s origin suspends and proposes debarment of the Wuhan Institute of Virology (WIV) “from participating in United States Federal Government procurement and nonprocurement programs.” In effect, this bars WIV from receiving U.S. government funding now and possibly ever. The ...
Source: ScienceNOW - July 20, 2023 Category: Science Source Type: news

Politicians, scientists spar over alleged NIH cover-up using COVID-19 origin paper
Two scientists who are coauthors of a 3-year-old article on the origin of the COVID-19 pandemic faced down Republican lawmakers today in what might be the most in-depth discussion ever of a scientific paper in the halls of the U.S. Congress. At a House subcommittee hearing , the Republicans asserted that top officials at the U.S. National Institutes of Health (NIH) prompted the researchers to write the paper to try and “kill” the theory that SARS-CoV-2 leaked from a laboratory in Wuhan, China. The scientists, two of its five co-authors, flatly rejected the allegation. And as the hearing extended over 3 hours, com...
Source: Science of Aging Knowledge Environment - July 11, 2023 Category: Geriatrics Source Type: research