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Combined oral intake of short and long fructans alters the gut microbiota in food allergy model mice and contributes to food allergy prevention
The objective of this study was to assess the food allergy-preventive effects of combined intake of a short fructan (1-kestose...
Source: BMC Microbiology - September 22, 2023 Category: Microbiology Authors: Hideaki Takahashi, Tadashi Fujii, Saki Yamakawa, Chikako Yamada, Kotoyo Fujiki, Nobuhiro Kondo, Kohei Funasaka, Yoshiki Hirooka and Takumi Tochio Tags: Research Source Type: research
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We would like to express our gratitude to Chen and Yong1 for their interest in our article entitled “Human genetics influence microbiome composition involved in asthma exacerbations despite inhaled corticosteroid treatment”.2 We read with enthusiasm their suggestions to increase the robustness of the genetic associations with microbiome composition that we reported in individuals from the Geno mics and Metagenomics of Asthma Severity (GEMAS) study.3
Source: Journal of Allergy and Clinical Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Javier Perez-Garcia, Maria Pino-Yanes, Fabian Lorenzo-Diaz Tags: Correspondence Source Type: research
Inhaled corticosteroid treatment's impact on asthma exacerbations: Influence of human genetics on microbiome composition
We read with great interest the study by Perez-Garcia et al1 on the human genetics that influence microbiome composition involved in asthma exacerbations despite inhaled corticosteroid (ICS) treatment. In this retrospective cohort study using data from the Genomic and Metagenomics of Asthma Severity (GEMAS) study, Perez-Garcia et al1 hypothesized a rel ationship between the genetic variants, microbiome associated with asthma exacerbation, and possible biologic pathway. To augment their findings, we would like to offer several suggestions on covariates that could be adopted and included in their study.
Source: Journal of Allergy and Clinical Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Yu-Jen Chen, Su-Boon Yong Tags: Correspondence Source Type: research
Prenatal dietary exposure to chemicals and allergy or respiratory diseases in children in the EDEN mother-child cohort
CONCLUSION: Prenatal dietary exposure to chemicals was associated with risk of allergic rhinitis or wheezing up to age 8 y. A few chemicals were associated with other allergic and respiratory diseases. Larger prospective studies are needed to confirm these findings.PMID:37734145 | DOI:10.1016/j.envint.2023.108195
Source: Environment International - September 21, 2023 Category: Environmental Health Authors: Manel Ghozal Manik Kadawathagedara Rosalie Delvert Karine Adel-Patient Muriel Tafflet Isabella Annesi-Maesano Am élie Crépet V éronique Sirot Marie Aline Charles Barbara Heude Blandine de Lauzon-Guillain Source Type: research
Bilastine 0.6% preservative-free eye drops, an effective once-daily treatment to reduce signs and symptoms of allergic conjunctivitis: A pooled analysis of two randomized clinical trials
CONCLUSION: This multi-trial assessment suggests that bilastine 0.6% ophthalmic solution is efficacious for the treatment of the signs and symptoms of allergic conjunctivitis, with a rapid and prolonged duration of action, and has a favorable safety profile. The added convenience of a once-a-day dosing regimen may contribute to patient adherence and improve their quality of life.PMID:37732873 | DOI:10.18176/jiaci.0940
Source: Journal of Investigational Allergology and Clinical Immunology - September 21, 2023 Category: Allergy & Immunology Authors: P J Gomes J B Ciolino P Arranz A Gonzalo N Fern ández G Hern ández Source Type: research
Very early onset perinatal constipation: Can it be cow's milk protein allergy?
World J Gastroenterol. 2023 Sep 7;29(33):4920-4926. doi: 10.3748/wjg.v29.i33.4920.ABSTRACTDelayed passage of meconium or constipation during the perinatal period is traditionally regarded as a signal to initiate further work up to evaluate for serious diagnoses such as Hirschsprung's disease (HD), meconium ileus due to Cystic Fibrosis, etc. The diagnosis of HD particularly warrants invasive testing to confirm the diagnosis, such as anorectal manometry or rectal suction biopsy. What if there was another etiology of perinatal constipation, that is far lesser known? Cow's milk protein allergy (CMPA) is often diagnosed in infa...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Rajalakshmy Arakoni Hebat Kamal Sam Xianjun Cheng Source Type: research
FDA Shoots Down Needle-Free EpiPen Alternative, Requests More Data
(MedPage Today) -- The FDA declined to approve an epinephrine nasal spray (ARS-1, also known as neffy), requesting that an additional premarketing study be conducted, maker ARS Pharmaceuticals announced.
The company is seeking an indication for...
Source: MedPage Today Allergy - September 21, 2023 Category: Allergy & Immunology Source Type: news
Fungal Allergen Sensitization: Prevalence, Risk Factors and Geographic Variation in the United States
Many fungal species are associated with the pathogenesis of allergic disease, yet most epidemiologic studies on IgE-mediated fungal sensitization have only included a few species.
Source: Journal of Allergy and Clinical Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Kenny Kwong, Matthew Robinson, Adam Sullivan, Stanley Letovsky, Andrew H. Liu, Andre Valcour Source Type: research
Climate change and epigenetic biomarkers in allergic and airway diseases
Human epigenetic variation is associated with both environmental exposures and allergic diseases and can potentially serve as a biomarker connecting climate change with allergy and airway diseases. In this narrative review, we summarize recent human epigenetic studies examining exposure to temperature, precipitation, extreme weather events, and malnutrition to discuss findings as they relate to allergic and airway diseases. Temperature has been the most widely studied exposure, with the studies implicating both short-term and long-term exposure with epigenetic alterations and epigenetic aging.
Source: Journal of Allergy and Clinical Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Andres Cardenas, Raj Fadadu, Supinda Bunyavanich Source Type: research
EpiPen Nasal Spray Suffers Setback as FDA Seeks Fresh Study EpiPen Nasal Spray Suffers Setback as FDA Seeks Fresh Study
The regulator has declined to approve a nasal spray that would have been the first needle-free emergency treatment for allergic reactions.Reuters Health Information
Source: Medscape Allergy Headlines - September 20, 2023 Category: Allergy & Immunology Tags: Pediatrics News Source Type: news
Real-world experience of hereditary angioedema (HAE) in Mexico: A mixed-methods approach to describe epidemiology, diagnosis, and treatment patterns
CONCLUSIONS: Despite efforts to make HAE visible, according to this study, cases recognized and treated in the NHS represent only 16.6% of the estimated prevalence.PMID:37727628 | PMC:PMC10506135 | DOI:10.1016/j.waojou.2023.100812
Source: Pain Physician - September 20, 2023 Category: Anesthesiology Authors: Sandra Nieto Ileana Madrigal Francisco Contreras Mar ía Eugenia Vargas Source Type: research
Dopamine Receptor 1 Impedes ILC2-Mediated Antitumor Immunity
In this study, we report that dopamine receptor 1 (DRD1) restrains ILC2 activity in the TME. DRD1 deficiency promotes ILC2 activation, which irritates eosinophil recruitment and cytotoxic CD8+ T cell expansion during ongoing malignancy. Consequently, DRD1-deficient mice exhibit delayed tumor growth and reduced tumor progression. Furthermore, fenoldopam, a selective DRD1 agonist, restrains the ILC2 response in the TME and aggravates tumor burden in mice. Taken together, our data elaborate that the DRD1 signal acts as an excitatory rheostat in regulating ILC2-dependent antitumor immunity.PMID:37728417 | DOI:10.4049/jimmunol.2300220
Source: Journal of Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Xiangyang Wang Xiangyu Chen Jierong Chen Chunhui Liao Xiaofan Yang Jiasheng Zhou Shanshan Liu Shusen Ye Yuhao Zheng Linzi Huang Jiacong Zhao Lilin Ye Bihui Huang Yingjiao Cao Source Type: research
