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Total 2046 results found since Jan 2013.
Association between HLA alleles and beta-lactam antibiotics-related severe cutaneous adverse reactions
Conclusion: This study demonstrated the candidate HLA alleles that are significantly associated with several phenotypes of beta-lactam antibiotics-related SCARs. However, whether the HLA alleles observed in this study can be used as valid genetic markers for SCARs related to beta-lactam antibiotics needs to be further explored in other ethnicities and larger cohort studies.
Source: Frontiers in Pharmacology - September 19, 2023 Category: Drugs & Pharmacology Source Type: research
Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051623-091038. Online ahead of print.ABSTRACTThe exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeuti...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada Daria Gafarov Maria Zaimi Joana Vitte Francesca Levi-Schaffer Source Type: research
Real-World Safety and Efficacy of Biosimilar CT-P13 in Patients with Immune-Mediated Inflammatory Diseases: Integrated Analysis of Three Japanese Prospective Observational Studies
ConclusionsThe integrated analysis of a large number of patients detected no new safety signals with long-term CT-P13 treatment. Efficacy in rheumatoid arthritis, psoriasis, Crohn ’s disease, and ulcerative colitis cases was confirmed in biologic-naïve patients and switched patients from the originator infliximab or other biologics.
Source: Drug Safety - September 12, 2023 Category: Drugs & Pharmacology Source Type: research
The clinical pharmacist role in patients with suspected allergy to beta-lactams: A systematic review
CONCLUSION: The pharmacist intervention in the evaluation of the patient with suspected allergy to beta-lactams is effective, safe and feasible to implement on daily clinical practice. The standardization of protocols to clarify the history of allergies and development of evaluation tools represent simple screenings to perform delabelling or refer to the Immunoallergology service, improving penicilins use and reducing the need for second line antibiotics. More studies are needed to standardize the desensitization tests made by pharmacists. However, despite these results, the involvement and leadership of the pharmacist in ...
Source: Farmacia Hospitalaria - September 11, 2023 Category: Drugs & Pharmacology Authors: Jesus Cotrina Luque Maria Jos é Rei Miriam Capoulas Cl áudia Santos Pedro Raimundo Source Type: research
Latex allergy - from discovery to component-resolved diagnosis
Endocr Metab Immune Disord Drug Targets. 2023 Sep 1. doi: 10.2174/1871530323666230901102131. Online ahead of print.ABSTRACTLatex allergy is a hypersensitivity response to natural rubber latex (NRL) proteins or rubber chemicals used in the manufacture of latex products. An accurate diagnosis is the first step in the effective management of individuals with latex allergy, especially in high-risk groups, such as healthcare workers and those affected by spina bifida. Diagnosis is based on the clinical history and an accurate allergological evaluation. In the case of type I IgE-mediated hypersensitivity re-actions, which can ma...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 8, 2023 Category: Drugs & Pharmacology Authors: Teresa Loverre Rossella Casella Andrea Miniello Danilo Di Bona Eustachio Nettis Source Type: research
