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Specialty: Rheumatology
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Total 1069 results found since Jan 2013.
The multifaceted role of mast cells in the pathogenesis of rheumatoid arthritis
Clin Exp Rheumatol. 2023 Sep 7. doi: 10.55563/clinexprheumatol/eontou. Online ahead of print.ABSTRACTMast cells (MC) are tissue duelling cells playing an active role in both innate and adaptive immune system. They act as first players in different microbial infections and exert a crucial role in allergy, chronic inflammation, fibrosis, and rheumatic diseases (RD), including rheumatoid arthritis (RA). MC are normally present in human synovia and they increase in the joints of RA patients, contributing to inflammatory and remodelling processes. Due to their great plasticity and multifunctionality, MC exert a wide range of ro...
Source: Clinical and Experimental Rheumatology - September 14, 2023 Category: Rheumatology Authors: Francesco Pisani Cristina Croia Fiorella Petrelli Erica Chericoni Paola Migliorini Ilaria Puxeddu Source Type: research
Neurological and endocrinological involvement in neonatal lupus erythematosus: a retrospective study at a tertiary hospital in Eastern China
ConclusionsAt our hospital, no significant gender differences were observed in the occurrence of NLE, and a predominance of skin, blood, liver, and heart involvement was observed. Patients with multiple central nervous system injuries and organ involvement are more likely to have growth retardation. Endocrine disorders are transient in NLE patients, and some showed feeding intolerance as the first manifestation.Key Points•A retrospective investigation of the clinical characteristics and prognosis of 39 NLE patients was performed, focusing on the clinical features of patients with neurological and endocrine system involve...
Source: Clinical Rheumatology - August 11, 2023 Category: Rheumatology Source Type: research
Conditioning of the immune system-Already clinically usable?
Z Rheumatol. 2023 Jul 4. doi: 10.1007/s00393-023-01384-9. Online ahead of print.ABSTRACTThe brain and the immune system permanently exchange information via various neuronal and humoral signaling pathways. This communication network forms the basis for controlling peripheral immune functions via associative learning or conditioning processes. Establishing a learned immune reaction, an immunomodulatory drug that represents the unconditioned stimulus (US) is paired with a new odor or taste stimulus. Re-presentating this previously neutral odor or taste stimulus, its now functions as a conditioned stimulus (CS) and triggers r...
Source: Zeitschrift fur Rheumatologie - July 4, 2023 Category: Rheumatology Authors: M Jakobs M Hadamitzky M Schedlowski L Hei ß-Lückemann Source Type: research
Correspondence on "Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: results from the COVID-19 Global Rheumatology Alliance physician registry" by Sparks et al
We read with great interest the Global Rheumatology Alliance report on COVID-19 on biologic or targeted synthetic disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis (RA).1 The first important result of the registry database is that B-cell depletion, by compromising the primary antibody response, increases the severity of infected patients. Considering the critical role of B cells in the adaptive immune response, this sounds quite correct.2 Even the data on interleukin 6 and tumour necrosis factor (TNF) inhibitors appear quite understandable considering the systemic inflammation raised by SARS-CoV-2 infe...
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Gremese, E., Ferraccioli, G. Tags: ARD, COVID-19 Correspondence Source Type: research
Sex differences in clinical manifestations of hospitalized patients with eosinophilic granulomatosis with polyangiitis: a retrospective cohort study
CONCLUSION: In this Chinese EGPA cohort, male and female patients showed distinct disease phenotypes. Male patients with EGPA had a higher disease activity at diagnosis and required more aggressive treatment for remission induction.PMID:37263648 | DOI:10.3899/jrheum.2022-1117
Source: Journal of Rheumatology - June 1, 2023 Category: Rheumatology Authors: Suying Liu Linna Han Mengtao Li Xinping Tian Xiaofeng Zeng Yuewu Lu Li Wang Fengchun Zhang Source Type: research
