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Total 169 results found since Jan 2013.

Prevention and Treatment of COVID-19-Associated Mucormycosis
AbstractPurpose of reviewThe present article will describe the unique factors present in COVID-19 patients that predispose these individuals to develop mucormycosis with emphasis placed on the prevention and treatment of COVID-19-associated mucormycosis (CAM).Recent findingsViral specific factors, pre-existing diabetes mellitus, and COVID-19 treatments combine to facilitate the development of mucormycosis. There appears to be a gross overutilization of steroid and antibiotic therapy among COVID-19 patients. Appropriate stewardship of antibiotic and steroid therapy in conjunction with tight glucose control may prevent the d...
Source: Current Treatment Options in Allergy - July 4, 2023 Category: Allergy & Immunology Source Type: research

Temporary arthrodesis through static spacer implantation in two-stage treatment of periprosthetic joint infections of the knee
Oper Orthop Traumatol. 2023 May 12. doi: 10.1007/s00064-023-00809-7. Online ahead of print.ABSTRACTOBJECTIVE: Treatment of chronic periprosthetic joint infection of the knee requires the removal of the implant and thorough debridement, with reimplantation in a second stage surgery. Intramedullary spacers can be helpful during the interval between explantation and reimplantation and provide a temporary arthrodesis which fixes the knee in extension preserving leg length and administers local antibiotic therapy.INDICATIONS: Periprosthetic joint infection of the knee with large bony defects and severe infection of the native j...
Source: Operative Orthopadie und Traumatologie - May 12, 2023 Category: Orthopaedics Authors: Max Jaenisch Soufian Ben Amar Mari Babasiz Alexander Seuser Hendrik Kohlhof Dieter Christian Wirtz Thomas Martin Randau Source Type: research

Penicillin Allergy Testing and Clearance in the Operational Setting: A Proof of Concept
Direct oral challenge for penicillin allergy has increasingly become a safe, cost-effective option especially in healthcare systems with limited access to allergy subspecialists. The military healthcare system has unique constraints in not only a paucity of allergists but "Authorized Medical Allowance Lists" aboard carriers/amphibious assault ships that carry principally penicillin antibiotics. Sailors with penicillin allergy are historically treated with often substandard antimicrobial therapy and even medically evacuated from ships while deployed, leading to costly and potentially dangerous patient transfers.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: William Day, Allyson Burkhart DeNora, Daniel Shields, Taylor Banks Source Type: research

Host-directed immunotherapy to fight infectious diseases
Purpose of review This review provides readers with examples of refractory infections due to inborn errors of immunity, highlighting how they may be successfully treated by deducing and targeting the underlying immunodeficiency. Recent findings The use of host-directed immunotherapy to treat infectious disease in inborn errors of immunity is currently limited but growing. Different strategies include depleting the cellular reservoir for pathogens with restricted cell-tropism; augmenting the diminished effector response; and restoring molecular equipoise. The immunotherapies illustrated are existing drugs that ha...
Source: Current Opinion in Pediatrics - November 7, 2022 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

Targeted Antibiotic Therapy Helpful for Sinusitis Management Targeted Antibiotic Therapy Helpful for Sinusitis Management
Empiric rhinosinusitis treatment is rife with antibiotic overuse. Are there ways to improve antibiotic stewardship for this common diagnosis?Medscape Medical News
Source: Medscape Allergy Headlines - November 2, 2022 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Implementing a referral protocol for penicillin allergy testing of pregnant women
Recent American College of Obstetrics and Gynecology (ACOG) guidelines advocate for the safety of penicillin allergy testing in pregnant women. Penicillin allergy de-labeling allows for preferred peripartum antibiotic therapy for Group B Streptococcus (GBS) prophylaxis and reduces IV antibiotics and neonatal ICU (NICU) care for newborns. Yet, there remains widespread hesitance to perform penicillin allergy testing on pregnant women.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: M. Patel, E. Stephen, L. Laursen, S. Bandi Tags: P205 Source Type: research

Primary Antibody Immunodeficiency and the Pregnant Patient
An overview of primary antibody immunodeficiency in pregnancy is presented. Indications for immunoglobulin replacement therapy (IGRT), dosing, and safety considerations are highlighted. Uses of immunizations and antimicrobial therapy are also discussed. In general, IGRT, both intravenous and subcutaneous, is considered safe in pregnancy.
Source: Immunology and Allergy Clinics of North America - October 27, 2022 Category: Allergy & Immunology Authors: Shouling Zhang, Charlotte Cunningham-Rundles Source Type: research

Severe Odontogenic Infections and the Penicillin Allergy Label: Institutional Review of Incidence and Outcomes
Odontogenic infections are commonly managed by oral and maxillofacial surgeons and generally require antimicrobial therapy with surgical management. Penicillins are a potent antibiotic in managing these infections, but 10% of the population has a penicillin allergic label (PAL). This label has limited their use and resulted in increased utilization of health care resources, antibiotic resistance, and complications associated with inappropriate use of antibiotics. Additionally, severe odontogenic infection patients are ascribed to many tests during the perioperative period.
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2022 Category: ENT & OMF Authors: Sagar Chadha, Paul Shivers, Jonathan P. Troost Source Type: research

Immediate hypersensitivity to oral doxycycline
In this study, we describe 2 well-documented immediate hypersensitivities (IHS) to doxycycline. We propose higher and nonirritating concentrations for skin prick tests (SPT) with tetracyclines.
Source: Annals of Allergy, Asthma and Immunology - June 24, 2022 Category: Allergy & Immunology Authors: Charlotte Hurson, Nada Maria Watchi Hayek, Perrine Dellis, Frederic de Blay, Carine Metz-Favre Tags: Letters Source Type: research

Early Empirical Use of Broad-Spectrum Antibiotics in Sepsis
AbstractPurpose of ReviewEarly antibiotic administration is the cornerstone of sepsis treatment guidelines and quality measures. We summarize recent key literature on sepsis definitions and screening, time-to-antibiotics and outcomes, and dosing considerations.Recent FindingsCurrent sepsis clinical criteria have limited utility for identifying patients who warrant urgent broad-spectrum antibiotics because they include a very heterogeneous population, including many patients later found to have non-infectious syndromes or mild transient illnesses. The best available evidence supports immediate antibiotic administration (wit...
Source: Current Infectious Disease Reports - March 30, 2022 Category: Infectious Diseases Source Type: research

Management of Acute Pediatric Rhinosinusitis
AbstractPurpose of ReviewThe goal of this paper is to discuss the current diagnostic criterion, pharmaceutical, and surgical treatments for pediatric acute rhinosinusitis with and without complications.Recent FindingsThe use of balloon sinuplasty to treat complicated acute frontal sinusitis, in the pediatric population, has been shown to be safe and effective.SummaryPediatric upper respiratory infections and acute bacterial rhinosinusitis are two of the most common diagnoses made in outpatient pediatric office visits. The majority of pediatric acute rhinosinusitis illnesses can be treated with conservative measures. Amoxic...
Source: Current Treatment Options in Allergy - March 29, 2022 Category: Allergy & Immunology Source Type: research

Treatment of Sinusitis Following Dental Implantation: A Systematic Review and Meta-Analysis
CONCLUSIONS: Endoscopic sinus surgery appears to be the most frequent treatment of choice for sinusitis following dental implantation, with excellent success rates. The protean clinical picture drawn from the selected studies calls for the standardization of diagnostics and definitions in this field to enable direct comparisons between the results of different studies. The role of postoperative antibiotic therapies, which have been employed unevenly across studies, should also be prospectively investigated.PMID:35244478 | DOI:10.1177/19458924221084484
Source: American Journal of Rhinology and Allergy - March 4, 2022 Category: ENT & OMF Authors: Fabiana Allevi Gian Luca Fadda Cecilia Rosso Federica Martino Carlotta Pipolo Giovanni Cavallo Giovanni Felisati Alberto Maria Saibene Source Type: research