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Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Breakfast cereal: a memoir
As awful for health as they are, having played such a huge role in childhood breakfasts, thoughts of breakfast cereals still conjure up a host of memories. Deep within the haze of my childhood memories, buried beneath recollections of nerdy high school days, a marriage gone sour, and a brother-in-law midlife crisis involving duct tape, three members of the local PTA, and a VW bus, are images of the mornings I sat with my two sisters at our kitchen table in suburban New Jersey, each of us slurping a bowl of Trix, Lucky Charms, or Fruit Loops cereal, still recovering from a late night of Bewitched and Mission Impossible. We ...
Source: Wheat Belly Blog - July 18, 2019 Category: Cardiology Authors: Dr. Davis Tags: Breakfast cereal grain-free wheat belly Source Type: blogs

Targeting Shelterin via TRF1 to Degrade Telomeres in Cancer Cells
Cancer cells depend on lengthening their telomeres, usually via telomerase activity. Telomeres are the caps of repeated DNA sequences at the ends of chromosomes. A little length is lost with each cell division, and when short a cell either self-destructs or becomes senescent and ceases replication. Cancer cells can only replicate continually if telomeres are extended continually. Thus some research groups are looking into sabotage of telomerase or the alternative lengthening of telomeres (ALT) processes as the basis for a truly universal cancer therapy. Others, as here, are investigating ways to interfere in mechanisms tha...
Source: Fight Aging! - July 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Real-World Evidence is What Pharma Needs Now to Help Cure Lung Cancer
The following is a guest blog post by Julie Krommenhoek from Ciox. Non-Small Cell Lung Cancer (NSCLC) is a designation that accounts for more than 80 percent of lung cancers diagnosed, and it has emerged as a new hotspot for investment by pharma manufacturers. Globally, the NSCLC therapeutics market is expected to rise to a […]
Source: EMR and HIPAA - July 11, 2019 Category: Information Technology Authors: Guest Blogger Tags: Administration Analytics/Big Data Clinical Health IT Company Healthcare IT HIM Hospital - Health System Revenue Cycle Management CDI CDQI Ciox CIOX Health Clinical Documentation Improvement Clinical Documentation Quality Improvem Source Type: blogs

California Court Grants Request by Terminally Ill Patients to Defend End of Life Option Act
The Riverside County Superior Court just granted a motion filed by Compassion & Choices on behalf of two terminally ill Californians seeking to intervene in the Ahn v. Hestrin lawsuit. The Court’s order will allow the intervenors to defend against the lawsuit, which seeks to overturn the state’s End of Life Option Act. The law allows mentally capable, terminally ill adults with six months or less to live to have the option to get a doctor’s prescription for medication they can decide to take if their suffering becomes unbearable, so they can die peacefully in their sleep.  In late May of 2018, a ...
Source: blog.bioethics.net - July 5, 2019 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs

Decades-Long Surveys Suggest The “Deleterious Effects of Smoking May Extend to Detrimental Personality Changes”
By Christian Jarrett There is increasing recognition that while our personality traits are stable enough to shape our lives profoundly, they are also partly malleable, so that our choices and experiences can feedback and influence the kind of people we become. A new study in the Journal of Research in Personality shines a light on a highly consequential behaviour that captures this dynamic – smoking cigarettes. The results add “… to existing knowledge on the implications of smoking by showing that this behaviour is also likely to alter individuals’ characteristic ways of thinking, feeling, and behaving ...
Source: BPS RESEARCH DIGEST - June 21, 2019 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Health Personality Source Type: blogs

Health Insurance 101 -- yet again
I just cannot understand why it is so difficult to get people to grasp what seems to me a simple idea. Let ' s try one more time.The purpose of insurance is to spread risk. That ' s the essence of the concept. Health insurance (or health care insurance as some prefer to say) is different from other kinds of insurance in some ways, so let ' s just talk about health insurance.Health care costs are unpredictable. It is true that there are risk factors associated with some conditions, most notably smoking tobacco. Nevertheless, no matter how healthful your lifestyle, you still just might need expensive health care. You might b...
Source: Stayin' Alive - June 14, 2019 Category: American Health Source Type: blogs

Study Concludes That Liquid Biopsies Can Help Guide Cancer Treatment
It now seems likely that liquid biopsies will have a well-defined and important role in the diagnosis of cancer and the screening of treated cancer patients for recurrences. The value of the procedure continues to improve due to new scientific discoveries (see:Scientific Breakthrough on the Correlation of Liquid Biopsies with Cancer Type) and a recent article was the most positive of any that I have read about the value of liquid biopsies (see:Liquid Biopsy Is Effective at Guiding Treatment of Lung Cancer, Study Finds). Below is an excerpt from it:...[T]wo years ago, Dr. Li and his colleagues [at Memorial Sloan Kettering] ...
Source: Lab Soft News - June 13, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Diagnostics Genomic Testing Lab Industry Trends Lab Processes and Procedures Medical Research Surgical Pathology Source Type: blogs

Tackling side effects in head and neck cancer treatment – the end of the road for hyperbaric oxygen?
Related items fromOnMedica Hundreds of lung cancer patients' lives cut short due to treatment variations NICE updates lung cancer guidance Cancer patients using complementary meds die sooner Sentinel node biopsy first to check spread of oral cancer Blood cancer patients feel ‘let down’ by NHS
Source: OnMedica Blogs - June 2, 2019 Category: General Medicine Source Type: blogs

Fight Aging! Newsletter, May 6th 2019
This study shows that mRNA levels of the aging related lamin A splice variant progerin, associated with premature aging in HGPS, were significantly upregulated in subjects with BMI ≥ 25 kg/m2. Moreover, our data revealed a significantly positive correlation of BMI with progerin mRNA. These data provide to our knowledge for the first-time evidence for a possible involvement of progerin in previously observed accelerated aging of overweight and obese individuals potentially limiting their longevity. Our results also showed that progerin mRNA was positively correlated with C-reactive protein (CRP). This might suggest an ass...
Source: Fight Aging! - May 5, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Mental Illness Deniers Are as Dangerous as Climate Change Deniers
Back in the mid-80’s, I was one of a few, fortunate psychiatrists in Massachusetts in charge of administering the just-released atypical antipsychotic medication clozapine. In our clinic, its use was still limited to a small number of carefully-selected patients with schizophrenia who had not responded to any of the conventional antipsychotic agents. Harry was one of my first clozapine patients. He had been an inpatient for much of his adult life, and was widely thought to be a “lost cause.” For many years, Harry had been tormented by threatening “voices” urging him to harm either himself or others. He had b...
Source: World of Psychology - May 4, 2019 Category: Psychiatry & Psychology Authors: Ronald Pies, M.D. Tags: Antipsychotic Bipolar Disorders Medications Psychiatry Schizophrenia Stigma Antipsychiatry Denial Hospitalization Mental Health over-prescription Stigmatization Thomas Szasz Source Type: blogs

Chronic Inflammation as Proximate Cause of a Large Fraction of Age-Related Disease
This popular science article discusses at length the chronic inflammation that is characteristic of the old, and its role as a proximate cause of age-related disease. Inflammation is a necessary part of the immune response to injury and pathogens, and when present in the short term it is vital to the proper operation of bodily systems. But when the immune system runs awry in later life, and inflammatory processes are constantly running, then this inflammation corrodes metabolism, tissue function, and health. The causes of excess, constant inflammation are both internal and external to the immune system. Internally, ...
Source: Fight Aging! - April 30, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Podcast: Bad Habits and Vices Related to Mental Illness
 Everyone has bad habits. Even your sainted Granny who seems perfect to you has some bad habit that only your grandfather knows about. Bad habits, like everything, exist on a spectrum, from biting your nails to snorting cocaine – and everything in between. In this episode, our hosts discuss bad habits that many people with mental illness seem to have – from smoking, to alcoholism, to drug use and, you guessed it, everything in between.   SUBSCRIBE & REVIEW “90% of people with schizophrenia smoke.” – Michelle Hammer   Highlights From ‘Bad Habits Mental Illness’’ Episode [0:...
Source: World of Psychology - April 15, 2019 Category: Psychiatry & Psychology Authors: A Bipolar, a Schizophrenic, and a Podcast Tags: A Bipolar, A Schizophrenic, and a Podcast Addiction Habits Schizophrenia Stress Source Type: blogs