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Cardiovascular risk in cancer survivors
Improvements in cancer care has its impact on better survival of those with early stage disease in several malignancies. In this scenario, cardiovascular disease has become a competing cause of death. It is not just due to chemotherapy induced myocardial disease, but also due to common risk factors for cardiovascular disease in this population. Hypertension, cigarette smoking and loss of cardiovascular fitness are some of them [1]. Weight gain may be also a problem in some. Those who have survived cancer for over 5 years have a 1.3 to 3.6 fold increased risk of cardiovascular mortality. Increased incidence of cardiovascu...
Source: Cardiophile MD - May 21, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Cancer and the Latino Community: Lessons Learned
I had the privilege this week to serve as the keynote speaker for the 4th Summit sponsored by Latinas Contra Cancer-an organization founded and led by Ysabel Duron, a formidable cancer survivor and news media presence in San Francisco.
Bringing together members of the Latino community, researchers, community health workers, promotores (more on that later) and advocates, the summit focused on the issues facing the Latino community in increasing awareness, access to care, improved treatment and research opportunities among other topics. But what was most impressive was the spirit, engagement and commitment that permeated the...
Source: Dr. Len's Cancer Blog - July 24, 2014 Category: Cancer Authors: Dr. Len Tags: Access to care Breast Cancer Cancer Care Cervical Cancer Colon Cancer Diet Early detection Environment Prevention Prostate Cancer Research Screening Tobacco Source Type: blogs
Cancer Survivors Exhibit a Significantly Higher Risk of Cardiovascular Disease
The dominant cancer therapies of chemotherapy and radiotherapy have not yet been replaced by immunotherapies for more than a handful of cancer types. These classes of therapy produce a significantly increased burden of senescent cells in patients; one of the goals of cancer therapy is to drive cancerous cells into senescence, those that cannot be killed. These additional senescent cells in turn accelerate the progression of degenerative aging. The advent of senolytic therapies to clear senescent cells from aged tissues will make a sizable difference to these patients. More effort should be undertaken today to enable patien...
Source: Fight Aging! - July 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
National Minority Health Month Is A Call To Action
April is National Minority Health Month.
That's the "dry" statement. The impact statement is that-unfortunately-for many in this country, this is more than a phrase. It's a reality that their health and their health care are in crisis. And the sooner more of us understand this, the sooner we can make a genuine effort to implement effective strategies that will address the sad state of affairs many people find themselves in when it comes to their health, and preventing and appropriately treating their diseases.
This is about more than high blood pressure and diabetes. It's about heart disease and stroke and cancer and the l...
Source: Dr. Len's Cancer Blog - April 18, 2013 Category: Cancer Authors: Dr. Len Tags: Access to care Breast Cancer Cancer Care Cervical Cancer Colon Cancer Early detection Environment Prevention Screening Survivors Treatment Source Type: blogs
Mortality Versus Survival In International Comparisons Of Cancer Care
In a recent paper, Soneji and Yang revisit a topic we first explored in the April 2012 issue of Health Affairs — namely, whether the U.S. gets value for its cancer care. We found that life expectancy after cancer diagnosis rose more quickly for patients in the U.S. than for patients in Europe. Moreover, while spending per patient also rose more quickly in the U.S., Americans still received good value from the health care system. Compared to the gains seen in Europe, for example, each additional life-year gained in the U.S. cost roughly $20,000 in additional U.S. spending.
Soneji and Yang re-examine trends in cancer d...
Source: Health Affairs Blog - March 20, 2015 Category: Health Management Authors: Dana Goldman, Darius Lakdawalla, and Tomas Philipson Tags: All Categories Business of Health Care Comparative Effectiveness Consumers Europe Health Care Costs Health Care Delivery Prevention Public Health Research Source Type: blogs
Cancer Survivors have Double the Risk of Suffering a Later Stroke
We present a contemporary analysis of risk of fatal stroke among more than 7.5 million cancer patients and report that stroke risk varies as a function of disease site, age, gender, marital status, and time after diagnosis. The risk of stroke among cancer patients is two times that of the general population and rises with longer follow-up time. The relative risk of fatal stroke, versus the general population, is highest in those with cancers of the brain and gastrointestinal tract. The plurality of strokes occurs in patients older than 40 years of age with cancers of the prostate, breast, and colorectum. Patients of any ag...
Source: Fight Aging! - December 9, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Combination hormonal therapy boosts survival in men with aggressive prostate cancer
A standard approach for treating aggressive prostate cancer is to give therapies that block testosterone, a tumor-stimulating hormone. Should initial hormonal therapies fail, doctors can switch to other drugs that suppress testosterone in different ways. One of them, a drug called abiraterone, has been shown to significantly extend lifespans in men who have become resistant to other hormonal treatments.
But in June, two major studies reported simultaneously that abiraterone also prolongs life in men with aggressive prostate cancer that’s been newly diagnosed. One of the studies, a phase 3 clinical trial called LATITUDE, ...
Source: Harvard Health Blog - August 18, 2017 Category: Consumer Health News Authors: Charlie Schmidt Tags: Cancer Health Men's Health Prostate Health Source Type: blogs
Heart disease and breast cancer: Can women cut risk for both?
Very often I encounter women who are far more worried about breast cancer than they are about heart disease. But women have a greater risk of dying from heart disease than from all cancers combined. This is true for women of all races and ethnicities. Yet only about 50% of women realize that they are at greater risk from heart disease than from anything else.
Currently in the US, three million women are living with breast cancer, which causes one in 31 deaths. Almost 50 million women have cardiovascular disease, which encompasses heart disease and strokes and causes one in three deaths.
Here’s what’s really interestin...
Source: Harvard Health Blog - January 8, 2019 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Breast Cancer Exercise and Fitness Health Healthy Eating Heart Health Women's Health Source Type: blogs
The Combination Diagnosis
Presto, you were a healthy person, who in addition to going out for drinks and appetizers with friends on weekends, you also used to go to the gym, hike, bike, swim, blah, blah, blah. All sorts of activities. Then, the ball drops. Now you have cancer and another ailment which prevents you from doing much of everything.You read about those ' other ' cancer people, who took their athleticism to new heights after their cancer diagnosis. They climb not just mole hills, but Mounts Everest and Denali in the same month. They learn to stand on the big fat boards and pole their way across the Pacific. They boast about their return ...
Source: Caroline's Breast Cancer Blog - June 18, 2017 Category: Cancer & Oncology Tags: cancer diagnosis disability Source Type: blogs
Empowering Stroke Survivors: Interview with Kirsten Carroll, General Manager at Kandu Health
Kandu Health, a digital health company based in California, has developed a platform to assist stroke survivors with aftercare. Healthcare for stroke patients is primarily focused on acute care to limit the damage caused by the stroke. However, the c...
Source: Medgadget - March 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Rehab kanduhealth stroke rehab Source Type: blogs
Empowering Stroke Survivors: Interview with Kirsten Carroll, CEO at Kandu Health
Kandu Health, a digital health company based in California, has developed a platform to assist stroke survivors with aftercare. Healthcare for stroke patients is primarily focused on acute care to limit the damage caused by the stroke. However, the c...
Source: Medgadget - March 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Rehab kanduhealth stroke rehab Source Type: blogs
Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 18th 2020
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function.
On Nutraceutical Senolytics
https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/
Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - May 17, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflamm...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
