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Fight Aging! Newsletter, August 6th 2018
In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging.
We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly individ...
Source: Fight Aging! - August 5, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Undoing Aging: Doug Ethell ' s Presentation on the Leucadia Therapeutics Approach to Treating Alzheimer ' s Disease
Doug Ethell has a clear and comparatively easily tested hypothesis on an important cause of Alzheimer's disease: that it results from the progressive failure of drainage of cerebrospinal fluid through one particularly crucial pathway in the skull. This traps ever greater levels of metabolic waste in the brain, such as amyloid-β, tau, and α-synuclein, and leads to the spectrum of well-known neurodegenerative diseases characterized by protein aggregates and resultant dysfunction and death of neurons.
Dave Gobel of the Methuselah Foundation backed the first work on this hypothesis a few years back, and the result is ...
Source: Fight Aging! - August 1, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Where Is the Boundary to Augment Life?
Cloning, CRISPR and gene editing, synthetic life forms, and longevity. The latest scientific discoveries are able to offset the natural order of human existence and meddle with sacred questions of life and death. Even so, does gaining insight into the secrets of being mean it should also be put into practice? Are we aware of the consequences? Where are the boundaries to augment life?
Life, death and the coin for Charon the Ferryman
In Japanese folklore, the Shinigami, gods or spirits of death came to the persons who were destined to die and invited them over the threshold of life and death. In ancient Egypt, Anubis, having...
Source: The Medical Futurist - July 28, 2018 Category: Information Technology Authors: nora Tags: Bioethics Cyborgization artificial intelligence augmentation bioethical cloning CRISPR death future gene editing Health Healthcare life longevity research synthetic life Source Type: blogs
Methadone and Mixed Messages
As a physician licensed to prescribe narcotics, I am legally permitted to prescribe the powerful opioid methadone (also known by the brand name Dolophine ) to my patients suffering from severe, intractable pain that hasn ’t been adequately controlled by other, less powerful pain killers. Most patients I encounter who might fall into that category are likely to be terminal cancer patients. I’ve often wondered why I am approved to prescribe methadone to my patients as a treatment for pain, but I am not allowed to prescribe methadone to taper my patients off of a physical dependence they may have developed from lo...
Source: Cato-at-liberty - July 13, 2018 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Particles Made of Silk Protect Immune System Boosting Drugs to Fight Cancer
Peptides, or strings of amino acids, are being investigated as a way to help activate the immune system to fight cancer and other diseases. Delivering them into the interior of immune system’s cells is difficult because they’re easily bro...
Source: Medgadget - June 14, 2018 Category: Medical Devices Authors: Editors Tags: Genetics Materials Source Type: blogs
Ending Aging Now Translated into Portuguese
Ending Aging is an important book, a concise explanation of the SENS approach to the development of rejuvenation therapies. It is aimed at laypeople, but with enough depth for scientists to use it as a starting point for their own further reading as well. It covers the extensive evidence gathered by the research community over the decades to support the concept that aging is caused by the accumulation of a few classes of molecular damage to cells and tissues. It outlines proposed therapies that could, if fully developed, repair or work around that damage in order to remove its contribution to aging.
Since its public...
Source: Fight Aging! - June 8, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Remember our past in order to protect the future of medicine
A guest column by the American College of Physicians, exclusive to KevinMD.com.
Her name is Wanda Poltawska. She is currently 96 years old and showing the physical signs of advanced aging, but remains mentally sharp and insightful.
What makes her special is that in 1941, at 19 years of age, she was sent to a concentration camp in Germany, and while there was subjected to medical “experimentation” by Nazi physicians. She was administered multiple drugs and underwent a variety of non-indicated procedures. And because she was Polish and imprisoned for subversive activities, using her as a subject for medical experimenta...
Source: Kevin, M.D. - Medical Weblog - June 6, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/philip-a-masters" rel="tag" > Philip A. Masters, MD < /a > Tags: Physician American College of Physicians Primary Care Source Type: blogs
The Top 12 Health Chatbots
Meet Molly, Eva, Ginger, Replika, Florence, Izzy – your new chatbot friends aiming to make your life better. In the last years, smart algorithm-powered, text or voice-based interfaces have multiplied, and they are also taking their place in healthcare. The Medical Futurist believes they will ease the burden on doctors in primary care and help patients learn to take care of their health responsibly. Do you want to try one? Check out the following health chatbots!
The age of chatting algorithms is coming
Last week, Google stunned the world with the latest feature of the Google Assistant, Duplex, that was able to make ...
Source: The Medical Futurist - May 25, 2018 Category: Information Technology Authors: nora Tags: imported AI artificial intelligence chatbot chatbots digital health future health chatbot Innovation List medical Medicine Personalized medicine technology Source Type: blogs
The Ethics of Keeping Alfie Alive
By SAURABH JHA
Of my time arguing with doctors, 30 % is spent convincing British doctors that their American counterparts aren’t idiots, 30 % convincing American doctors that British doctors aren’t idiots, and 40 % convincing both that I’m not an idiot.
A British doctor once earnestly asked whether American physicians carry credit card reading machines inside their white coats. Myths about the NHS can be equally comical. British doctors don’t prostate every morning in deference to the NHS, like the citizens of Oceania sang to Big Brother in Orwell’s dystopia. Nor, in their daily rounds, do they calculate opportun...
Source: The Health Care Blog - May 21, 2018 Category: Consumer Health News Authors: at RogueRad Tags: OP-ED Uncategorized AlfieEvans Source Type: blogs
Fight Aging! Newsletter, May 14th 2018
This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition.
In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - May 13, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bacteria Carrying Red Blood Cells as Microswimmers to Deliver Drugs Inside Body
Man-made nano and micro particles are a dime a dozen these days, with all sorts of mechanisms built-in to deliver drugs, help spot cancer, and destroy tumors. Now researchers at the Max Planck Institute for Intelligent Systems in Germany have develo...
Source: Medgadget - May 1, 2018 Category: Medical Devices Authors: Editors Tags: Genetics Nanomedicine Source Type: blogs
The deadly false hope of German alternative cancer clinics, part 3: Hallwang Clinic revisited
I've written twice before about German alternative medicine cancer clinics, the quackery they ply, and how they take advantage of desperate cancer patients. Finally, in a disturbing report a journalist has investigated what one of these clinics (Hallwang) does and how such clinics can continue to operate.
The post The deadly false hope of German alternative cancer clinics, part 3: Hallwang Clinic revisited appeared first on RESPECTFUL INSOLENCE.
Source: Respectful Insolence - April 2, 2018 Category: Surgery Authors: Orac Tags: Cancer Medicine Quackery alternative medicine Farrah Fawcett featured Hallwang Clinic Hallwang Private Oncology Clinic Source Type: blogs
Fight Aging! Newsletter, March 19th 2018
In this study, we did not observe significant age-dependent upregulation of the prominent SASP cytokine Il6 in any tissue, although an upward trend was observed that was consistent in magnitude with previous observations in the heart and kidney. This modest age-related upward trend could be explained by a previous report which demonstrated that senescent cell-secreted IL-6 acts in an autocrine manner, reinforcing the senescent state, rather than inducing senescence or promoting dysfunction in neighboring cells.
The decreased expression of Il6 with age we observed in the hypothalamus could be indicative of a lack or ...
Source: Fight Aging! - March 18, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Undoing Aging: An Interview with Aubrey de Grey
The Undoing Aging conference in Berlin is presently underway, a gathering of everyone who is anyone in the rejuvenation research community. It is hosted jointly by the SENS Research Foundation and the Forever Healthy Foundation, and is a unification of the varied themes of the past fifteen years of SENS conferences: the science of aging and its treatment from the earlier SENS conference series mixed with the industry, startup, and commercial development focus of the Rejuvenation Biotechnology series of recent years.
The first rejuvenation therapies to be implemented and shown to work, those based on clearance of sen...
Source: Fight Aging! - March 16, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
I Treated the Columbine Kids. I Have Not Spoken Out Before.
By NIRAN AL-AGBA, MD
A National School Walkout Day is planned for March 14, 2018 at 10 a.m. and will last 17 minutes in honor of the 17 students and staff members killed at Marjory Stoneman Douglas High School in Parkland, Florida, on Valentine’s Day. The heart of the nation has seemed to shift overnight regarding the debate on guns, but this change has been almost two decades in the making. United and Delta Airlines pulled their support for the NRA, Dicks’ Sporting Goods will not sell assault-style weapons, and Walmart plans to raise the minimum age to purchase a gun to 21 years old.
I am a pediatrician. I treated the...
Source: The Health Care Blog - March 10, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
