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Total 141 results found since Jan 2013.

Pain and Circumstance
My wife Diane and I visited our friend Mary in the hospital on Friday. Mary had just had her “knee replaced” — which is a rather spectacular modern procedure, unimagined not too many years ago. Another modern, commonplace aspect of this kind of surgery was being “enjoyed” by Mary – her morphine-on-demand dispenser! Her machine delivered a small dose of morphine intravenously every time she thought she needed it, with the proviso that no request would be granted until 6 minutes had passed since the last slug. Mary’s setup, combined with Memorial Day, reminded me of a landmark stud...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - January 1, 2021 Category: Neuroscience Authors: Dr. Merzenich Tags: Aging and the Brain Brain Fitness BrainHQ Source Type: blogs

The Great Bucatini Shortage of 2020 and the FDA ’s History of Telling Italians How to Make Italian Food
Michael F. CannonRachel Handler has a  delightfulpiece atNew Yorkmagazine ’s food and restaurant blogGrub Street on how Big Pasta is using government regulation to punish competitors and consumers. The result is that the U.S. Food and Drug Administration, in addition to causing a  shortage of COVID-19diagnostic tests andvaccines, is basically causing a  nationwide shortage of bucatini.On March 30, at the beginning of a  pandemic whose supply shocks were making everything from toilet paper to pasta harder to get, the FDAblocked imports of De Cecco bucatini. The FDA found the iron content of the Italian company’s bu...
Source: Cato-at-liberty - December 30, 2020 Category: American Health Authors: Michael F. Cannon Source Type: blogs

The Great Transformation
This is the title of a  book published in 1944 by the Hungarian-American political economist Karl Polanyi. It is widely considered to be an important work in political economy, so read it if you can.But the Wikipedia summary actually isn ' t bad. Polanyi addresses many of the problems and issues that concerned Karl Marx, but with 100 years of added perspective, including of course the experience of actually existing Communism. I ' m going to run a trick play here and quote from the Communist Manifesto, which was first published in 1848. (The wordsmithing was actually mostly by Friedrich Engels, who was a better commun...
Source: Stayin' Alive - December 21, 2020 Category: American Health Source Type: blogs

What I Got Wrong (and Right) about COVID19
In May, I wrote a column about COVID19 that got some attention. My reason for writing was the change in messaging about the strategy of flatten-the-curve. We were first told to flatten-the-curve to prevent overwhelming hospitals. But then the thinking changed to flatten-the-curve to save lives.  I made eight assertions about COVID19. Let’s see how I did.  Assertion 1: The virus will not be contained. Verdict: Correct. You might argue that New Zealand and Australia contained the virus, but I would counter that these are not fair comparisons to the US, Canada, and the EU.  Assertion 2: Tests...
Source: Dr John M - December 12, 2020 Category: Cardiology Authors: Dr John Source Type: blogs

Symani Microsurgical System Cleared in Europe
Medical Microinstruments (MMI), a company based outside of Pisa, Italy, won the European CE Mark of approval for its Symani robotic surgical system. The product provides 7-20X scaling of hand movements, automatically removing tremors to allow for saf...
Source: Medgadget - November 18, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Neurosurgery Orthopedic Surgery Plastic Surgery Vascular Surgery Source Type: blogs

Fight Aging! Newsletter, November 16th 2020
This study conclusively demonstrates the long-speculated relationship between aging, gene regulation, and somatic damage. The results open up new avenues of research with practical implications. If the same level of coordination reduction between genes is indeed a leading cause for aging phenomena, there may be a need to change course in current efforts to develop aging treatments. Using Oligodendrocyte Extracellular Vesicles to Induce Tolerance to Myelin as a Treatment for Multiple Sclerosis https://www.fightaging.org/archives/2020/11/using-oligodendrocyte-extracellular-vesicles-to-induce-tolerance-to-myelin-a...
Source: Fight Aging! - November 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Hormonal treatments for prostate cancer may prevent or limit COVID-19 symptoms
Men have roughly twice the risk of developing severe disease and dying from COVID-19 than women. Scientists say this is in part because women mount stronger immune reactions to the disease’s microbial cause: the infamous coronavirus called SARS-CoV-2. Now research with prostate cancer patients points to another possible explanation, which is that the male sex hormone testosterone helps SARS-Cov-2 get into and infect human cells. SARS-CoV-2 initiates infections by first latching onto its human cell receptor. But it can only pass into a cell with the aid of a second protein called TMPRSS2. Testosterone regulates TMPRSS...
Source: Harvard Health Blog - September 10, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Living With Prostate Cancer Prostate Knowledge Treatments HPK Source Type: blogs

Digital Health Makes Healthcare Globalised
Consider Atlas Biomed, the company behind the at-home microbiome test: it is based in the U.K. Some 1,900 kilometers away in Italy, Dante Labs offers direct-to-consumer whole genome sequencing kits. On the other side of the Atlantic Ocean, in the U. S., is Fitbit, which ships its fitness trackers around the world. Despite being headquartered in different countries and even in different continents, patients now have access to quality digital health services wherever they are (save for some shipping restrictions). This aspect of digital health heralds one of its lesser-explored advantages: it enables healthcare to be ...
Source: The Medical Futurist - August 18, 2020 Category: Information Technology Authors: Prans Tags: Future of Medicine Healthcare Design Healthcare Policy digital health Source Type: blogs

Fight Aging! Newsletter, August 10th 2020
This study aimed to characterize the role of BDNF in age-related microglial activation. Initially, we found that degrees of microglial activation were especially evident in the substantia nigra (SN) across different brain regions of aged mice. The levels of BDNF and TrkB in microglia decreased with age and negatively correlated with their activation statuses in mice during aging. Interestingly, aging-related microglial activation could be reversed by chronic, subcutaneous perfusion of BDNF. Peripheral lipopolysaccharide (LPS) injection-induced microglial activation could be reduced by local supplement of BDNF, while shTrkB...
Source: Fight Aging! - August 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

My Journey from Fear to Love
"Everything will be okay in the end. If it's not okay, it's not the end." – John Lennon January - 2012 I remember sitting in a small dark room waiting for the surgeon to arrive. My son had just had major surgery, and it had taken much longer than expected. My stomach felt tense as the surgeon sat in the chair opposite us. He looks at the floor as he started to speak. "it's not good news," he said. "We think he has a week left to live." After that, my mind switched off. I felt my wife's head on my shoulder and heard her tears. Was it a bad dream? June – 2017 My feet feel heavy as I am ne...
Source: PickTheBrain | Motivation and Self Improvement - July 30, 2020 Category: Consumer Health News Authors: Thomas Westenholz Tags: creativity family featured happiness relationships self-improvement fear love self improvement Source Type: blogs

Fight Aging! Newsletter, June 22nd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 21, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Blood Pressure Control Increases Life Expectancy Even in the Most Frail Elderly People
Chronically raised blood pressure, or hypertension, is highly damaging to tissues throughout the body. It is an important mechanism linking the molecular damage of aging to gross structural damage to organs, causing loss of function, age-related disease, and death. Many of the underlying causes of aging lead to stiffness of blood vessel walls, from cross-linking in the extracellular matrix to the effects of senescent cell signaling on vascular smooth muscle cells. That stiffness causes dysfunction in the regulation of blood pressure, which in turn causes pressure damage, increased pace of the development of atherosclerosis...
Source: Fight Aging! - June 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Choosing Between Life and Death During COVID-19: The A.I. Trolley Problem
Suppose you’re the sole witness of a trolley that has gone out of control, hurtling towards 5 people tied to its track, with no way to stop it in time. Good news: there’s a lever you can pull to alter its direction. Bad news: the other track isn’t safe either as it has one person tied to it. What will you do in this situation? Let the trolley continue on its initial course and kill those 5 people on the way or pull the lever to save them at the expense of that other person’s life? Source: https://www.lionsroar.com/ This ethical thought experiment, known as the Trolley Problem, was put forth by Philippa Foot b...
Source: The Medical Futurist - May 14, 2020 Category: Information Technology Authors: Prans Tags: Artificial Intelligence Bioethics Future of Medicine Healthcare Policy covid19 Source Type: blogs

Fight Aging! Newsletter, May 4th 2020
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease. Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus https://www.fightaging.org/archives/2020/04/notes-on-self-experim...
Source: Fight Aging! - May 3, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

COVID-19: Physicians in Shackles
By ANISH KOKA, MD A number of politically tinged narratives have divided physicians during the pandemic. It would be unfortunate if politics obscured the major problem brought into stark relief by the pandemic: a system that marginalizes physicians and strips them of agency. In practices big and small, hospital-employed or private practice, nursing homes or hospitals, there are serious issues raising their heads for doctors and their patients. No masks for you When I walked into my office Thursday, March 12th, I assembled the office staff for the first time to talk about COVID.  The prior weekend had been awa...
Source: The Health Care Blog - May 2, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Physicians Anish Koka medical autonomy Pandemic Source Type: blogs