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Fight Aging! Newsletter, September 19th 2022
Conclusion Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life. Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases. Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

AI Is Close to Giving Us the Ultimate Early Diagnostic Test For Breast Cancer
By HUGH HARVEY, MD 1986 was a great year. In the heyday of the worst-dressed decade in history, the Russians launched the Mir Space Station, Pixar was founded, Microsoft went public, the first 3D printer was sold, and Matt Groening created The Simpsons. Meanwhile, two equally important but entirely different scientific leaps occurred in completely separate academic fields on opposite sides of the planet. Now, thirty two years later, the birth of deep learning and the first implementation of breast screening are finally converging to create what could be the ultimate early diagnostic test for the most common cancer in wom...
Source: The Health Care Blog - March 5, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

Make Asbestos Great Again? - Trump Once Claimed " Movement Against by Asbestos was Led by the Mob, " Now is EPA Wants to Relax Asbestos Regulation
Introduction:  An Old Public Health MenaceThis is somewhat personal.  In the early 1980s, as a general internal medicine fellow, I gave a series of talks about important medical problems that generalist physicians often missed.  One was asbestos related disease.  Although asbestos had been heavily regulated since 1973, there were stilll large numbers of people exposed to it alive in the 1980s.  One of my primitive slides, seemingly a picture of type writing, stated that around then, 2 to 4 million people who had histories of significant asbestos exposure were likely alive.  Asbestos is known t...
Source: Health Care Renewal - August 10, 2018 Category: Health Management Tags: asbestos cancer conflicts of interest Donald Trump public health Source Type: blogs

I see you –– but don’t ask me how I’m doing
On the worst day of my life, I noticed how many times an hour Americans ask some version of “how’s it going?” without actually wanting to know the answer. It happens when we pass each other in the halls at work, at the park, in line at Starbucks. We ask when making small talk before getting down to business. It even happens when we are waiting for the test results that reveal we have cancer. How’s it going? On January 19, 2018, I parried that question five or six times before one of my best friends at the office asked it. It felt like I would be lying to not answer. “This week, man—” But I had to stop. How do...
Source: Harvard Health Blog - June 4, 2019 Category: Consumer Health News Authors: Adam P. Stern, MD Tags: Cancer Health Mental Health Relationships Source Type: blogs

Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism. Mouse Age Matters: How Age Affects the Murine Plasma Metabolome A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols. FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, April 8th 2019
This study did not confirm the hypothesis that ELL individuals have lower polygenic risk scores for cardiovascular-related phenotypes. Only the HDL cholesterol and triglyceride PRS were nominally significantly associated with ELL participants. In contrast and as expected, ELL individuals had higher polygenic risk scores for exceptional longevity (EL). In regards to the associations of the various cardiovascular PRS with EL, no findings survived correction for multiple testing. This is despite validating the utility of the lipid PRS by confirming positive associations with measured lipid levels in our sample. Interestingly,...
Source: Fight Aging! - April 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Weekly Australian Health IT Links – 1 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----Quite a lot this week – especially regarding the NBN and Labor trying to regain control of what it is actually for – service provision – and not making a huge profit – in their view. Love the new Minister has ambitions to be maximally photogenic and not a ‘techie’!Otherwise all sorts of fun things!-----https://www.ausd...
Source: Australian Health Information Technology - August 1, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

RIP Andrea Rich
I am saddened to report that my dear friend Andrea Millen Rich  died this morning at her home in Philadelphia at the age of 79 after a 19-year battle with lung cancer. She was, among many other things, the proprietor of Laissez Faire Books and the wife for 41 years of Howard Rich, the Cato Institute’s longest-serving Board member.For more than 40 years Andrea was at the center of the libertarian movement, a mentor, counselor, friend, supporter, facilitator, networker, and gracious hostess to hundreds of freedom lovers – young, old, well-known, obscure, successful, down-on-their-luck, didn’t matter. She was the firs...
Source: Cato-at-liberty - August 1, 2018 Category: American Health Authors: David Boaz Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
August 25, 2022 Edition-----The big story this week has been the multiple PM story in Australia with ScoMo. What an amazing saga!In the UK there seems to be an impending collapse of the economy coming unless some-one takes some really smart steps real soon now.Relatively the US has seemed pretty calm this week – just waiting for an impending recession – along with China and Europe.Fair to say things globally are pretty messy!-----Major Issues.-----https://www.afr.com/markets/equity-markets/every-investing-trend-misfires-as-stock-bears-are-crushed-20220814-p5b9o2Every investing trend misfires as stock bears are crushedD...
Source: Australian Health Information Technology - August 25, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Cynical Hawks Exploit North Korea Crisis to Torpedo Iran Agreement
Donald Trump ’sspeech to the UN General Assembly underscored his intention to adopt highly confrontational policies toward both North Korea and Iran.  He threatened to “totally destroy” North Korea in the event of war and re-emphasized Washington’s long-standing determination to compel Pyongyang to renounce its nuclear and ballistic missile programs. The president scorned Iran as “an economically depleted rogue state” and described the current multilateral nuclear agreement with Tehran as “an embarrassment” to the United States. If Trump is not merely engaging in bombast, Washington appears to be ginning-u...
Source: Cato-at-liberty - September 20, 2017 Category: American Health Authors: Ted Galen Carpenter Source Type: blogs

Blockchain + Gold
ConclusionI am not endorsing or recommending investment in any of these projects. Caveat emptor. But I think the last three listed warrant our attention as attempts, in the spirit of E-gold, to provide modern gold-based payment systems with online access. All three explicitly promisenot to hold fractional reserves, and say that you can track the volume of cryptoasset on their ledger to see that it matches the number of gold grams or ounces held in their vaults. But if one of them becomes popular as a one-hundred-percent-reserved   goldpayment system, perhaps a subsequent innovator will offer zero storage fees and interest...
Source: Cato-at-liberty - October 26, 2017 Category: American Health Authors: Lawrence H. White Source Type: blogs

Two Things Nearly Everyone Gets Wrong About the Michael Flynn Case
Clark NeilyI ' ve been reading,writing, and tweeting about the Michael Flynn prosecution quite a bit lately, and I ' ve  been getting significant feedback from people who strongly dislike Flynn and think he ' s about to get away with committing a serious crime due to sinister political machinations behind the scenes. As explained in this post, I take no strong position on Flynn ' s character or whether he did or did not commit any crimes —most Americans have, so he ' d be in good company.   But I think many in the " lock him up " crowd are making two  fundamental errors that are in urgent need of correction. Thos...
Source: Cato-at-liberty - May 22, 2020 Category: American Health Authors: Clark Neily Source Type: blogs

The New Deal and Recovery, Part 18: The Recovery So Far
George Selgin(Although my contributions to this series have so far been more-or-less in their proper order, this one isn ' t: it occurred to me only relatively recently that it would be worthwhile to take stock of the overall progress of the recovery up to the outbreak of the Roosevelt Recession before delving into that episode. Had I done this in the first place, this installment would be Part 10 of the series, with the present Part 10 and all subsequent installments moved up a notch. –Ed.)When it struck down the Agricultural Adjustment Act in January 1936, the Supreme Court dropped the final curtain on the original New...
Source: Cato-at-liberty - June 1, 2022 Category: American Health Authors: George Selgin Source Type: blogs