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An Update on Immune System Recreation as a Treatment for Multiple Sclerosis
The destruction of near all immune cells followed by cell therapy to speed recreation of the immune system is a fairly harsh procedure, as the only way to clear a sufficiently high fraction of immune cells at the moment is essentially a form of chemotherapy. It is an effective treatment for autoimmune conditions, however, albeit with a significant risk of death, in line with that for many major surgeries. This makes it suitable in its current form only for more severe autoimmune disorders in which the patients tend to be younger and more robust, but with a very poor prognosis. In past years researchers have demonstrated co...
Source: Fight Aging! - March 20, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
AI Is Close to Giving Us the Ultimate Early Diagnostic Test For Breast Cancer
By HUGH HARVEY, MD
1986 was a great year. In the heyday of the worst-dressed decade in history, the Russians launched the Mir Space Station, Pixar was founded, Microsoft went public, the first 3D printer was sold, and Matt Groening created The Simpsons. Meanwhile, two equally important but entirely different scientific leaps occurred in completely separate academic fields on opposite sides of the planet. Now, thirty two years later, the birth of deep learning and the first implementation of breast screening are finally converging to create what could be the ultimate early diagnostic test for the most common cancer in wom...
Source: The Health Care Blog - March 5, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, February 12th 2018
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - February 11, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Studies of identical twins can provide good answers
In another entry related to the neuroscience of aging, I cited a study by Heflin et al on the significantly negative mental consequences of surviving cancer and its treatments. This “twins study” was one of a series of such experiments that have come from the University of Southern California research team of Margaret Gatz. Her group’s research is a good starting point for learning about environmental contributors to cognitive deficits and senility, because studies conducted in identical twins (she relies heavily on a large Swedish identical-twin roster) eliminate known contributions of genetics and child...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - February 1, 2018 Category: Neuroscience Authors: Dr. Merzenich Tags: Aging and the Brain Brain Fitness Source Type: blogs
New Breast Cancer Research Found A Factor that Doubles Death Risk
Isn ' t that a warm fuzzy feeling? Now I want toask my oncologist if I have this factor. But first let me see if I can explain it. This is the precis:" Researchers at Karolinska Institutet in Sweden have discovered that the risk of death from breast cancer is twice as high for patients with high heterogeneity of the estrogen receptor within the same tumour as compared to patients with low heterogeneity. The study, which is published in The Journal of the National Cancer Institute, also shows that the higher risk of death over a span of 25 years is independent of other known tumour markers and also holds true for Luminal A ...
Source: Caroline's Breast Cancer Blog - January 21, 2018 Category: Cancer & Oncology Tags: breast cancer treatment cancer research cancer risk hormone receptor status Source Type: blogs
The Price of Progress
By ANISH KOKA, MD
No one knows who Bennie Solis is anymore.
He had the misfortune of being born in the early 1960s marked for death. He had a rare peculiar condition called biliary atresia – a disease defined by the absence of a conduit for bile to travel from his liver to his intestinal tract. Bile acid produced in the liver normally travels to the intestines much like water from a spring travels via ever larger channels to eventually empty into the ocean. Bile produced in the liver with no where to go dams up in the liver and starts to destroy it.
That the liver is a hardy organ was a fact known to the ancient Gree...
Source: The Health Care Blog - January 4, 2018 Category: Consumer Health News Authors: anish_koka Tags: Uncategorized Source Type: blogs
MINOCA – Myocardial infarction with non obstructive coronary arteries
Myocardial infarction with non obstructive coronary arteries (MINOCA) [1] had a prevalence of 6% among myocardial infarctions noted in a recent systematic review [2]. They are more likely to be younger and female, but less often have dyslipidemia as a risk factor. Other risk factors were found to be similar. Total mortality at one year with MINOCA is about 4.7% compared to 6.7% with myocardial infarction associated with obstructive coronary artery disease. Typical myocardial infarction as demonstrated by cardiac magnetic resonance imaging (CMR) was noted only in about one fourth of cases. One third had myocarditis while ab...
Source: Cardiophile MD - November 14, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
The Dunning-Kruger Effect, Or the Real Reason Why the Guys Trying to “ Fix ” Health Care Are Driving You Crazy
By HANS DUVEFELT, MD
“The fool doth think he is wise, but the wise man knows himself to be a fool.”
– Willam Shakespeare
I learned about the Dunning-Kruger effect at a medical conference recently. It certainly seems to apply in medicine. So often, a novice thinks he or she has mastered a new skill or achieved full understanding of something complicated, but as time goes on, we all begin to see how little we actually know. Over time, we may regain some or most of our initial confidence, but never all of it. Experience brings at least a measure of humility.
Just the other day I finished a manuscript for an article i...
Source: The Health Care Blog - November 3, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Dunning-Kruger Effect Medicine practice of medicine Source Type: blogs
Gluten, Depression, and Anxiety: The Gut-Brain Link
In this study, 22 participants ate a gluten-free diet low in FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) for a three-day baseline period, and then received one of three dietary challenges (supplemented with gluten, whey, or placebo) for three days, followed by a three-day minimum washout period before starting the next diet.
Researchers assessed the participants at the end of the study using a psychological tool called the Spielberger State-Trait Personality Inventory (STPI). People in the study who consumed gluten had higher overall STPI depression scores compared to those on th...
Source: World of Psychology - October 20, 2017 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Alternative and Nutritional Supplements Anxiety and Panic Depression Health-related Mental Health and Wellness Research brain-gut connection celiac disease Gluten Gluten sensitivity Schizophrenia Source Type: blogs
When an erythrocyte sedimentation rate leads to a serious diagnosis
In Sweden, back when I trained, three blood tests were the “routine labs” done at most doctor visits: hemoglobin, white blood cell count, and erythrocyte sedimentation rate. I’m trying to remember, but I don’t think everyone waited an hour to see the doctor, so they must have used a modified rapid sedimentation rate.
The “sed rate,” or “sänkan” as we call it, was invented by Robin Fåhraeus, a relative of one of my High School teachers. Fåhraeus described the phenomenon in his doctoral dissertation in 1921 and was a professor of anatomy and pathology at Uppsala University around the time I was born. He wa...
Source: Kevin, M.D. - Medical Weblog - August 1, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/a-country-doctor" rel="tag" > A Country Doctor, MD < /a > Tags: Conditions Cancer Source Type: blogs
Fight Aging! Newsletter, July 17th 2017
This study aimed to estimate associations between combined measurements of BMI and waist-to-hip ratio (WHR) with mortality and incident coronary artery disease (CAD). This study followed 130,473 UK Biobank participants aged 60-69 years (baseline 2006-2010) for 8.3 years (n = 2974 deaths). Current smokers and individuals with recent or disease-associated (e.g., from dementia, heart failure, or cancer) weight loss were excluded, yielding a "healthier agers" group.
Ignoring WHR, the risk of mortality for overweight subjects was similar to that for normal-weight subjects. However, among normal-weight subjects, mortalit...
Source: Fight Aging! - July 16, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Recent Epidemiological Research Relevant to the Understanding of Aging
This study aimed to estimate associations between combined measurements of BMI and waist-to-hip ratio (WHR) with mortality and incident coronary artery disease (CAD). This study followed 130,473 UK Biobank participants aged 60-69 years (baseline 2006-2010) for 8.3 years (n = 2974 deaths). Current smokers and individuals with recent or disease-associated (e.g., from dementia, heart failure, or cancer) weight loss were excluded, yielding a "healthier agers" group.
Ignoring WHR, the risk of mortality for overweight subjects was similar to that for normal-weight subjects. However, among normal-weight subjects, mortalit...
Source: Fight Aging! - July 14, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Living with ‘Lagom’: Swedish Moderation for a Longer, Healthier Life
You're reading Living with ‘Lagom’: Swedish Moderation for a Longer, Healthier Life, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
Wellness advice from The Nordic Guide to Living 10 Years Longer: 10 Easy Tips for a Happier, Healthier Life.
One of our favorite expressions in Sweden is "Lagom is best." “Lagom is a word that is hard to translate, but an attempt would be “just right”. “Lagom is best” hence means that having just the right amount of something—not too much, not too little—is perfect. Thi...
Source: PickTheBrain | Motivation and Self Improvement - April 27, 2017 Category: Consumer Health News Authors: Greystone Tags: diet happiness health and fitness popular Suggested Reading Bertil Marklund best self improvement blog Greystone Books just right Lagom Nordic Guide pickthebrain well being wellness Source Type: blogs
