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High-Throughput Testing of Hundreds of Anti-Cancer Drug Combinations
Researchers at ETH Zurich in Switzerland have developed a high-throughput screening method for anti-cancer drugs that they have called “pharmascopy”. To date, the researchers have tested the system with multiple myeloma samples, a cancer ...
Source: Medgadget - May 11, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology ETH Zurich ethz Nature Cancer Source Type: blogs

Hormonal treatments for prostate cancer may prevent or limit COVID-19 symptoms
Men have roughly twice the risk of developing severe disease and dying from COVID-19 than women. Scientists say this is in part because women mount stronger immune reactions to the disease’s microbial cause: the infamous coronavirus called SARS-CoV-2. Now research with prostate cancer patients points to another possible explanation, which is that the male sex hormone testosterone helps SARS-Cov-2 get into and infect human cells. SARS-CoV-2 initiates infections by first latching onto its human cell receptor. But it can only pass into a cell with the aid of a second protein called TMPRSS2. Testosterone regulates TMPRSS...
Source: Harvard Health Blog - September 10, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Living With Prostate Cancer Prostate Knowledge Treatments HPK Source Type: blogs

Fight Aging! Newsletter, September 12th 2022
Discussion of Present Drug Development to Target Senescent Cells Targeting Senescent Cells to Better Address Cancer and Consequences of Cancer Therapy Calorie Restriction Suppresses Generation of Immune Cells via Changes to the Gut Microbiome Arguing for an Expansion of the Hallmarks of Aging https://www.fightaging.org/archives/2022/09/arguing-for-an-expansion-of-the-hallmarks-of-aging/ The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. This i...
Source: Fight Aging! - September 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Breathtaking: The Future Of Respiratory Care And Pulmonology
Smoke-measuring smart shirts, breath sound analyzing algorithms, and smart inhalers pave the way of pulmonology and respiratory care into the future. As the number of patients suffering from asthma, COPD, or lung cancer due to rising air pollution and steady smoker-levels will unfortunately not decrease any time soon, we looked around what technology can do to help both patients and caregivers. The results are breathtaking. Attacks of breathlessness are too common The diseases which pulmonologists and respiratory care specialists attempt to fight are among the most common conditions in the modern world – and the n...
Source: The Medical Futurist - September 25, 2019 Category: Information Technology Authors: nora Tags: Artificial Intelligence Future of Medicine Health Sensors & Trackers AI asthma cancer cancer treatment care COPD diagnostics inhaler lung lung cancer management medical specialty pulmonology respiratory respiratory care Source Type: blogs

How Much of Late Life Cancer is Easily Avoidable?
A range of data on the benefits produced by simple health interventions in late life suggests that many people are self-sabotaging to a point at which a significant fraction of age-related disease and mortality might be legitimately thought of as being self-inflicted. To pick one example, if programs of moderate exercise improve health and reduce mortality in old people, which they do, then the conclusion must be that older people are harming themselves by not undertaking sufficient exercise. Cancer is one of the more important classes of age-related condition. It is age-related for a range of reasons, such as risin...
Source: Fight Aging! - May 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Genetically Engineered Tattoo Shows Up if Person Has Cancer
As everyone knows, early diagnosis brings the best chance of fighting cancer. At ETH Zurich, a Swiss technical university, researchers genetically modified skin cells to produce a tattoo that makes itself visible only when the person wearing it has s...
Source: Medgadget - April 19, 2018 Category: Medical Devices Authors: Editors Tags: Diagnostics Oncology Source Type: blogs

Digital Health Ventures That Flew Too Close To The Sun
1.5 billion: that’s the number, in dollars, Forbes put for Proteus’ valuation last year. Dubbed as a healthcare unicorn, the startup even raised over $500 million in venture capital. It made headlines for developing the first-ever FDA-approved digital pill, one equipped with an ingestible and trackable sensor to monitor treatment compliance.  Researchers even proved the technology’s worth. In 2019, an independent study investigated the Proteus’ digital pill. They found it to be accurate, and even improved adherence of tuberculosis patients using oral pills equipped with Proteus’ system. https://ww...
Source: The Medical Futurist - July 7, 2020 Category: Information Technology Authors: Prans Tags: Artificial Intelligence Future of Medicine Future of Pharma Genomics AI cancer IBM google deepmind theranos Watson fail digital pill proteus deus ex machina tech giants finances otsuka Nightingale Source Type: blogs

The New Buzz: These Are The Top Examples Of Digital Therapeutics
Digital Therapeutics or DTx in short is one of the latest buzzwords in the digital health ecosystem. Unlike others (NFT, Metaverse just to name a few) however, we see DTx as a meaningful trend that has the capacity to bring short-term, substantial improvements in personalised healthcare.  What is Digital Therapeutics? The definition by the Digital Therapeutics Alliance, the main professional hub is:  “Digital therapeutics (DTx) deliver evidence-based therapeutic interventions that are driven by high-quality software programs to prevent, manage, or treat a medical disorder or disease. They are used inde...
Source: The Medical Futurist - June 21, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Digital Health Research Future of Medicine Health Sensors & Trackers Telemedicine & Smartphones software chronic pain apps cancer care mental health DTx digital therapeutics eczema Atopic dermatitis sleep disorders Source Type: blogs

Particles Made of Silk Protect Immune System Boosting Drugs to Fight Cancer
Peptides, or strings of amino acids, are being investigated as a way to help activate the immune system to fight cancer and other diseases. Delivering them into the interior of immune system’s cells is difficult because they’re easily bro...
Source: Medgadget - June 14, 2018 Category: Medical Devices Authors: Editors Tags: Genetics Materials Source Type: blogs

Tumors Grown in 3D from Cancer Patient Samples for Drug Screening
Cancerous tumors can be very inconsistent in how they respond to different therapies. While the tumor of one patient can rapidly shrink when exposed to a given medication, another patient suffering from the same kind of tumor may not get any benefit ...
Source: Medgadget - June 19, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Medicine Oncology Source Type: blogs

Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells. Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Emergency Spending Is on the Rise: Here ’s How Congress Can Stop It
Romina Boccia and Dominik LettCongress has spent a  combined $1 trillion through supplemental appropriations over the last five years in inflation‐​adjusted 2021 dollars. While most of the supplemental spending since 2020 was in response to COVID-19, supplemental appropriations are on the rise over the long term (chart below).Supplemental appropriations are primarily emergency spending that falls outside of regular budgeting procedures. Congress is increasingly using crises as justifications to spend more. Now, the Biden administration has asked Congress to tack on an additional$85 billion in emergency spending to dis...
Source: Cato-at-liberty - December 20, 2022 Category: American Health Authors: Romina Boccia, Dominik Lett Source Type: blogs

Fight Aging! Newsletter, December 2nd 2019
In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications. To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence? https://www.fightaging.org/archives/2019/11/to-what-degree-does-loss-of-skeletal-muscle-with-age-contribute-to-immunosenescence/ Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable process...
Source: Fight Aging! - December 1, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, December 17th 2018
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α. Moreover, Atg5 knockdown alone was sufficient to trigger...
Source: Fight Aging! - December 16, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Price of Progress
By ANISH KOKA, MD No one knows who Bennie Solis is anymore. He had the misfortune of being born in the early 1960s marked for death. He had a rare peculiar condition called biliary atresia – a disease defined by the absence of a conduit for bile to travel from his liver to his intestinal tract. Bile acid produced in the liver normally travels to the intestines much like water from a spring travels via ever larger channels to eventually empty into the ocean. Bile produced in the liver with no where to go dams up in the liver and starts to destroy it. That the liver is a hardy organ was a fact known to the ancient Gree...
Source: The Health Care Blog - January 4, 2018 Category: Consumer Health News Authors: anish_koka Tags: Uncategorized Source Type: blogs