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The FDA ’s Culture: Should Safety Dominate All Practices?
By STEVEN ZECOLA
An organization’s culture is an internal set of shared values, attitudes and practices. The cohesiveness of the organizational culture will affect whether the entity will meet its vision, purpose, and goals.
One type of organizational culture is hierarchical in nature. Unlike a risk-taking culture, this structure features policy, process and precision. It is best suited for mature and stable organizations.
The disadvantage of a hierarchal culture is that its stability and control can turn into rigidity. In many cases, the organization develops a negative attitude towards ideas s...
Source: The Health Care Blog - August 26, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy FDA Parkinson's Disease Steven Zecola Source Type: blogs
What is Primary Health?
I’ve been writing a blog post on this topic for a few months.
It’s gone through several iterations and has survived a half-dozen friendly editors. This post isn’t that post, which still needs honing and will follow in the coming days. This post is the personal prelude – the why that perhaps is important to share before the what.
Simon Sinek says we should start with why.
Here goes:
My decision to go to medical school was long-delayed. Indeed – I took no science classes in college – assuring myself that I would not follow the path of my father and grandfathers – all of wh...
Source: Docnotes - August 25, 2021 Category: Primary Care Authors: Jacob Tags: Health Uncategorized Source Type: blogs
Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflamm...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
We Live in an Age of Biotechnology, In Which We Could Choose to End the Suffering of Aging
Bringing degenerative aging under medical control, ending the tens of millions of deaths each year, ending the suffering of hundreds of millions more. This is a plausible goal for our era of biotechnology. Yet even as the first rejuvenation therapies have become a reality, in the form of first generation senolytic drugs that clear a sizable fraction of senescent cells from the body, there is little public enthusiasm for - and understanding of - the path ahead to a better world. A world in which people have the choice not to decay in body and mind as they gather wisdom and experience in later life. Change is in the air, but...
Source: Fight Aging! - August 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reverse Potts Shunt for Pulmonary Arterial Hypertension in Children
Potts shunt was a surgical anastomosis between left pulmonary artery and descending aorta to improve pulmonary blood flow in cyanotic congenital heart disease with decreased pulmonary blood flow. It is a systemic to pulmonary shunt. The report was published one year after the Blalock-Taussig shunt which was also used for a similar purpose [1]. Later Potts shunt like other central aortopulmonary shunts, were discontinued because of higher risk of excessive pulmonary blood flow. A modified Blalock-Taussig shunt is still in use.
Reverse Potts shunt is a pulmonary to systemic shunt for relieving pulmonary arterial hypertensio...
Source: Cardiophile MD - August 4, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Anti ‐Vaxxers Turn to Big Government
Thomas A. FireyCOVID-19hospitalizations anddeaths are rising in the United States as the highly infectious Delta variant of the SARS-CoV-2 virus has becomethe dominant strain in the country. These serious cases arealmost entirely limited to people who are not vaccinated against the virus; for the vaccinated,infection rates are much lower and nearly all infections are no more troublesome than a cold or — at worst – a bout of the flu, and often go unnoticed altogether.COVID-19 causedat least11 percent of all U.S. deaths in 2020, making it thethird leading cause of death, behind only heart disease and cancer. So far in 20...
Source: Cato-at-liberty - August 2, 2021 Category: American Health Authors: Thomas A. Firey Source Type: blogs
Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Treating Aging as a Medical Condition Should Long Have Been a Priority
Aging kills most people in the world, and near all people in the wealthier parts of the world. It doesn't just kill, but also produces decades of declining health and capabilities, increased pain and suffering. Addressing the causes of aging, uncovering the mechanisms of aging and treating them, should have been the top priority in medicine ever since the advent of modern antibiotics allowed for control over the majority of infectious disease. Decades in which meaningful progress could have taken place have been wasted, and work on the mechanisms of aging is still only a small field within the life sciences, a small indust...
Source: Fight Aging! - July 23, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future.
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Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Using Supercentenarian Data to Estimate Future Increases in Maximum Human Life Span
In today's research materials, scientists attempt to model future increases in maximum human longevity based on past data for supercentenarians, people aged 110 and older. This is an interesting exercise, but I think that all of the results have to be taken with a sizable grain of salt. Firstly, the data for extreme human outliers in longevity isn't great. A lot of it is of poor quality, and the portions that are well maintained do not include a sizable number of people. There are few survivors to such exceptional ages, which makes it hard to call any analysis of that data truly robust. This is a problem that afflicts all ...
Source: Fight Aging! - July 8, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Fable of the Cats
George SelginThe comparison has by now been made so often that it may qualify as a platitude. I mean that between stablecoin issuers and “wildcat” banks, the fly‐by‐night scams that supposedly flooded the antebellum United States with notes nominally worth some stated amount of gold or silver, but actually worth little more than the rag paper they were made of.Such disreputable stuff, we keep hearing, is what “private” currency always tends to be like. The paper sort survived until federal authorities nationalized the nation’s paper money during the Civil War. And (we are told), digital currency will...
Source: Cato-at-liberty - July 6, 2021 Category: American Health Authors: George Selgin Source Type: blogs
Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all.
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gro...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
13 Technologies That Will Shape The Future Of Cancer Care
Immediately upon being elected, U.S. President Joe Biden had a task to solve. Amidst taking a hold on the virus, he, however, did not forget about a health issue he’d previously been involved in. In his first major address to Congress this April, Biden asked lawmakers to help him “end cancer as we know it.” The U.S.’s ambition to stop cancer deaths began with the project Moonshot Biden was responsible for under the presidency of Barack Obama. While Moonshot hasn’t yet proved successful, the amount of money spent on research has its mark on the outcome.
The United States spends more money on cancer than any ot...
Source: The Medical Futurist - June 10, 2021 Category: Information Technology Authors: Judit Kuszkó Tags: Covid-19 Forecast Artificial Intelligence in Medicine Biotechnology Digital Health Research E-Patients Future of Medicine Genomics Health Sensors & Trackers Healthcare Design Medical Education Nanotechnology Personalized Medicine Source Type: blogs
If Lawmakers Really Want to “Follow the Science” They Will Repeal Codified Opioid Guidelines
This study documents a relationship between opioid prescribing and opioid overdose in a large, national, prospective cohort of individuals receiving opioid therapy for a variety of medical conditions. The risk of opioid overdose should continue to be evaluated relative to the need to reduce pain and suffering and be considered along with other risk factors.University of Alabama Professor of Medicine Stefan Kerteszpointed out thatfollow up research led by Bohnert found the median overdose dosage was 60 MMEs and 86 percent occurred under 90 MMEs. Yet he cautioned policymakers:Reliance on a simple binary dose metric is an ext...
Source: Cato-at-liberty - May 24, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated.
Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
https://www.fightaging.org/archiv...
Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
