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Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect How to Construct Measures of Biological Age A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome Intestinal Barrier Dysfunction as a Feature of Aging in Many Species NAFLD as an Age-Related Condition Towards Sensory Hair Cell Regeneration in the Inner Ear Raised Levels of PLG...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

COVID-19: If you ’re older and have chronic health problems, read this
By now, you’ve probably heard this warning about the new coronavirus pandemic: those who are older and have a chronic medical condition are at increased risk for severe disease and death. If you fall into this category, here’s important information about the coronavirus outbreak tailored to you. If you look at the data, older adults and those with chronic health problems who get COVID-19 are more likely to require hospitalization and admission to an intensive care unit. And so far in the US, 80% of the deaths from the new coronavirus virus have occurred in people who were older. But this raises a number of questions: ...
Source: Harvard Health Blog - April 1, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Healthy Aging Infectious diseases Men's Health Prevention Women's Health Source Type: blogs

Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

HDAC Inhibition Suppresses the Senescence-Associated Secretory Phenotype
The research materials here cover the recent work of one of many groups digging deeper in the mechanisms of cellular senescence, in search of novel ways to make senescent cells less harmful to surrounding tissues, or means to selectively destroy them outright. The accumulation of senescent cells with age is now well proven to contribute to aging, generating chronic inflammation and disrupting tissue function via a potent mix of signals known as the senescence-associated secretory phenotype, or SASP. The scientists involved here have discovered that HDAC inhibitors can to some degree suppress the SASP, and this intervention...
Source: Fight Aging! - March 3, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

What Are Opioid Overdose Signs?
On average, 130 Americans die from an opioid overdose every day. The Centers for Disease Control and Prevention (CDC) considers opioid overdose an epidemic in the United States, estimating it responsible for nearly 68 percent of 70,000 drug-related deaths in 2017. Understanding the effects of opioids can prevent opioid overdose, and knowing the opioid overdose signs can save lives. What Are Opioids? Opioids are a class of drugs naturally found in the opium poppy plant. Opioid drugs reduce pain by binding to opioid receptors in your brain, spinal cord and other areas of the body, creating morphine-like effects. The CDC ide...
Source: Cliffside Malibu - November 21, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Addiction Heroin Painkiller Substance Abuse drug overdose opiate opiate abuse opiate addiction opiates opioid opioids Source Type: blogs

Antibiotic-resistant urinary tract infections are on the rise
There is a global crisis of antibiotic resistance, and urinary tract infections (UTIs) may be the canary in the coal mine. UTIs are one of the most common types of infections; at least one in two women and one in 10 men will experience a UTI in their lifetime. Like many human infections, UTIs are usually caused by bacteria living on or in our bodies, and require treatment with antibiotics. What’s alarming the medical community now is that UTIs are becoming ever harder to treat with common antibiotics. Antibiotic overuse leads to antibiotic resistance At some point, most people have taken a course of trimethoprim/sulfamet...
Source: Harvard Health Blog - October 14, 2019 Category: Consumer Health News Authors: Lisa Bebell, MD Tags: Drugs and Supplements Health Infectious diseases Kidney and urinary tract Women's Health Source Type: blogs

Fatty liver disease: What it is and what to do about it
Non-alcoholic fatty liver disease (NAFLD), a condition of extra fat buildup in the liver, is on the rise — it now affects roughly 20% to 40% of the US population. It usually doesn’t cause any symptoms, and is often first detected by accident when an imaging study (such as an abdominal ultrasound, CT scan, or MRI) is requested for another reason. A fatty liver may also be identified on an imaging test as a part of investigating abnormal liver blood tests. NAFLD is intimately related to conditions like diabetes and obesity. It’s also linked to an increased risk of cardiovascular disease. Understanding NAFLD and its cau...
Source: Harvard Health Blog - January 10, 2019 Category: Consumer Health News Authors: Wynne Armand, MD Tags: Digestive Disorders Health Source Type: blogs

Navigating back pain treatments: Can a physiatrist help?
If self-care steps for back pain such as gentle activity, local heat, or massage don’t ease discomfort within a few weeks to a month, or if you struggle with chronic low back pain, a physiatrist can help you navigate the dizzying number of treatment options. These range from conservative therapies (such as medicines, physical therapy, and chiropractic care) to more invasive options (such as spine injections and spinal surgery). What is a physiatrist? Physiatrists are medical doctors who specialize in physical medicine and rehabilitation. We focus on holistic, nonsurgical care aimed at improving function for people who ar...
Source: Harvard Health Blog - October 10, 2018 Category: Consumer Health News Authors: Edward N. Wei, MD Tags: Back Pain Bones and joints Health Pain Management Source Type: blogs

How to talk to your doctor about medication
Pharmacology has changed the practice of medicine. Scientists are continually working on new and better drugs to manage medical conditions, from high blood pressure to autoimmune diseases to cancer. The mechanism of a drug — how it actually works on the condition it is mean to treat — is one important factor, but drug delivery, meaning how the medication arrives at the target it is meant to affect, is also key. As a patient, it’s your right to understand everything about a medication prescribed for you. That doesn’t mean you have to become a scientist or pass an exam about pharmacology. But you can and should ask y...
Source: Harvard Health Blog - April 23, 2018 Category: Consumer Health News Authors: Carolyn A. Bernstein, MD, FAHS Tags: Drugs and Supplements Health Health care Source Type: blogs

The Other Opioid Crisis: Hospital Shortages Lead To Patient Pain, Medical Error
I came across this public-accesss story, and wanted to share the perspective: Pauline Bartolone, Kaiser Health News Even as opioids flood American communities and fuel widespread addiction, hospitals are facing a dangerous shortage of the powerful painkillers needed by patients in acute pain, according to doctors, pharmacists and a coalition of health groups. The shortage, though more significant in some places than others, has left many hospitals and surgical centers scrambling to find enough injectable morphine, Dilaudid and fentanyl — drugs given to patients undergoing surgery, fighting cancer or suffering traumatic i...
Source: Suboxone Talk Zone - March 26, 2018 Category: Addiction Authors: admin Tags: Acute Pain Anesthesia Public policy surgery Chronic pain opioid addiction Source Type: blogs

Hospitalized Patients Are Civilian Casualties in the Government ' s War on Opioids
A recentstory by Pauline Bartolone in the Los Angeles Times draws attention to some under-reported civilian casualties in the government ’s war on opioids: hospitalized patients in severe pain, in need of painkillers. Hospitals across the country are facing shortages of injectable morphine, fentanyl, and Dilaudid (hydromorphone). As a result, trauma patients, post-surgical patients, and hospitalized cancer patients frequently go un dertreated for excruciating pain.Hospitals, including the ones in which I practice general surgery, are working hard to ameliorate the situation by asking medical staff to use prescription opi...
Source: Cato-at-liberty - March 18, 2018 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

Digital Health Supports The Fight Against Opioids
The widespread U.S. opioid & overdose crisis is an ever-increasing tragic concern for everyone: writhing victims, family members being fain to see their relatives suffer or die, doctors prescribing opioid pain-killers what they thought before as safe, and regulators imposed to handle a tough situation. Addiction. It’s painful to even read about the skyrocketing numbers of people suffering, thus we decided to map how digital health could help tackle the opioid crisis. Why is it so difficult to deal with the opioid crisis? Once you become addicted, it sticks with you for a long time, if not for life, just as a chronic...
Source: The Medical Futurist - November 14, 2017 Category: Information Technology Authors: nora Tags: Bioethics Mobile Health Virtual Reality in Medicine AI artificial intelligence data data analytics drugs future gc3 Innovation opioid opioid crisis pharma technology wearables Source Type: blogs

Cutting down on opioids has made life miserable for chronic pain patients - Slate
On July 26, Todd Graham, 56, a well-respected rehabilitation specialist in Mishawaka, Indiana, lost his life. Earlier that day, a woman complaining of chronic pain had come to Graham's office in hope of receiving an opioid such as Percocet, Vicodin, or long-acting OxyContin. He reportedly told her that opioids were not an appropriate first-line treatment for long-term pain —a view now shared by professionals—and she, reportedly, accepted his opinion. Her husband, however, became irate. Later, he tracked down the doctor and shot him twice in the head.This horrific story has been showcased to confirm that physicians ...
Source: Psychology of Pain - August 30, 2017 Category: Anesthesiology Source Type: blogs