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Technological Progress Is Really Off And Rolling At An Amazing Pace!
 Last week I had the misfortune to have what I have been led to believe was a small myocardial infarction, which I am happy to report I have apparently survived. In true doctor fashion I had been ignoring some minor chest discomfort until last Sunday week when a doctor friend insisted I go an be a ssessed at the local teaching hospital (RNSH) at which I had worked decades ago. My, have things
Source: Australian Health Information Technology - September 6, 2023 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

What Is Pharmacology?
Credit: iStock. Pharmacology is the study of how molecules, such as medicines, interact with the body. Scientists who study pharmacology are called pharmacologists, and they explore the chemical properties, biological effects, and therapeutic uses of medicines and other molecules. Their work can be broken down into two main areas: Pharmacokinetics is the study of how the body acts on a medicine, including its processes of absorption, distribution, metabolism, and excretion (ADME). Pharmacodynamics is the study of how a medicine acts in the body—both on its intended target and throughout all the organs and tissue...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Genomics Medicines Miniseries Source Type: blogs

Consciously Exploring Your Relationship with Drugs
Humanity has a complex, long-term relationship with a wide variety of drugs. In this article let’s delve into your personal relationship with drugs, how you frame them, and how you might upgrade these relationships to be more conscious and aligned with your path of self-development. Let’s include common drug sources like coffee, tea, and chocolate too, so this will be very inclusive. My purpose here isn’t to encourage or discourage you from using any particular substances but rather to invite you to take a more conscious and honest look at your current frames, attitudes, biases, and behaviors, and dete...
Source: Steve Pavlina's Personal Development Blog - July 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Health Lifestyle Relationships Values Source Type: blogs

How Automation Can Help Ease Healthcare Worker Burnout
The following is a guest article by Anna Twomey, Senior Director, Healthcare Providers – Americas at SS&C Blue Prism   With rising staffing shortages and burnout among healthcare workers, digital transformation will be key to overcoming these challenges and protecting patient care. It’s estimated that the U.S. could see a shortage of up to 124,000 physicians by 2033 and will need to hire at least 200,000 nurses per year to meet increased demand and to replace retiring nurses. The healthcare worker burnout crisis in this country began before the COVID-19 pandemic, but the public health emergency m...
Source: EMR and HIPAA - June 28, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Anna Twomey BPM Business Process Management Digital Transformation EHR Healthcare Automation Healthcare Burnout IA Intelligent Automa Source Type: blogs

Building a Digital Immune System
Credit: Courtesy of Dr. Tomas Helikar. The power of computer code has been a longtime fascination for Tomas Helikar, Ph.D., a professor of biochemistry at the University of Nebraska-Lincoln (UNL). In college, when he learned he could use that power to help researchers better understand biology and improve human health, Dr. Helikar knew he’d found his ideal career. Since then, he’s built a successful team of scientists studying the ways we can use mathematical models in biomedical research, such as creating a digital replica of the immune system that could predict how a patient will react to infectious microorganisms ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 28, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Cool Tools/Techniques Modeling Profiles Source Type: blogs

Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models. The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Attacking Cancer by Disabling Macrophage Recognition of CD47 " Don ' t Eat Me " Marker
CD47 is a "don't eat me" decoration found on the surface of cells. This is a necessary mechanism for the prevention of autoimmunity, but it is also subverted by cancer in order to prevent the innate immune system from attacking tumor cells. The cancer research community has investigated a range of approaches to prevent CD47 from holding back the immune response to cancerous cells. One possibility, demonstrated here, is to engineer the innate immune cells known as macrophages in order to block the CD47 interaction and thus ensure an aggressive response to cancerous cells. Cancer remains one of the leading causes of...
Source: Fight Aging! - June 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Career Conversations: Q & A With Physiologist Elimelda Moige Ongeri
Credit: Courtesy of Dr. Elimelda Moige Ongeri. A career path in science is rarely clear cut and linear, which Elimelda Moige Ongeri, Ph.D., can attest adds to its excitement. She went from working in animal reproductive biology to studying proteins involved in inflammation and tissue injury. Dr. Ongeri is also currently dean of the Hairston College of Health and Human Sciences and professor of physiology at North Carolina Agricultural and Technical State University (NC A&T) in Greensboro. In this interview, she shares details of her career, including a change in research focus to human physiology; her goals for the f...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Proteins Source Type: blogs

Heartwarming stories of cancer patients teaching us about life and the human spirit
I felt uneasy starting my oncology and leukemia rotations. These patients were so sick, and many of them had incurable cancer, often just weeks or days away from death. I wondered how I could help them, what we could do if we couldn’t treat their cancer. I’m grateful that these patients taught me not just Read more… Heartwarming stories of cancer patients teaching us about life and the human spirit originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - May 30, 2023 Category: General Medicine Authors: Tags: Physician Oncology/Hematology Source Type: blogs

Why is being a patient a difficult pill to swallow?
While being treated for an aggressive hematologic cancer, the former head of a department of medicine at a large teaching hospital told me he wished he could hang a sign on his headboard, reading P-I-P: Previously-Important-Person. Despite extraordinary achievements, skills, credentials, and status, being a patient made him feel like an amalgam of parts; limbs, Read more… Why is being a patient a difficult pill to swallow? originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - May 20, 2023 Category: General Medicine Authors: Tags: Physician Primary Care Source Type: blogs

Another day to think, to pause, to ponder.
Panorama of Sycamore Park and the memorial to Karim A bit over 10 years ago I wrote a blog post that I repost all the time. Entitled "A day to think, to pause, to ponder" it was posted on my dad ' s birthday and was about the pain of him dying, by suicide, when I was in college. It was meant as a sad, melancholy post but also one about the importance of compassion and how " we can all do a little bit to improve how we treat other. " When I reposted this one time a few years ago, someone asked me if I had ever met the " Compassion Guy " who frequented downtown Davis and who had a life ' s mission of getting people to t...
Source: The Tree of Life - May 5, 2023 Category: Microbiology Tags: DavisCA UCDavis Karim Majdi Abou Najm David Breaux Kimberlee Guillory compassion Source Type: blogs

Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context. Glycine Supplementation as a Methionine Restriction Mimetic https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/ Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restrictio...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A man in his 60s with acute chest pain and high voltage
Sent by Anonymous, written by Pendell MeyersA man in his 60s with history of CAD and 2 prior stents presented to the ED complaining of acute heavy substernal chest pain that began while eating breakfast about an hour ago, and had been persistent since then, despite EMS administering aspirin and nitroglycerin. There was associated diaphoresis, but no dyspnea, nausea, or vomiting. He reported having covid 2 weeks ago, but had seemingly fully recovered.Triage 1104:What do you think?The triage ECG was sent to me with no history (I did not have access to baseline ECGs), and I said that I thought this was just LVH causing the an...
Source: Dr. Smith's ECG Blog - April 14, 2023 Category: Cardiology Authors: Pendell Source Type: blogs

Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo. T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/ Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reprogramming Tumor Cells into Antigen-Presenting Cells
Today's research materials describe a clever approach to cancer immunotherapy, focused on the goal of enabling the immune system to better identify cancerous cells. In the past, researchers have made some inroads in training the immune system to attack specific target molecules characteristic of cancerous cells, but this is a slow and expensive process when progressing from single target to single target. Further, any given cancer might be capable of evolving to function without exhibiting any one specific target molecule, and only some cancers of a particular type will exhibit that specific signature molecule to start wit...
Source: Fight Aging! - March 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs