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Total 127 results found since Jan 2013.

Microneedle Skin Patch Measures Cancer Biomarkers
Researchers at the Harvard Wyss Institute have developed a technique that lets clinicians to characterize and monitor melanoma. The system involves using a microneedle patch that can draw deep interstitial fluid into itself through a series of penetr...
Source: Medgadget - September 14, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Dermatology Diagnostics Medicine Oncology harvard wyssinstitute Source Type: blogs

Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models. The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions. Plasma Transfer Lowers Epigenetic Age and Mortality in Rats https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/ Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains me...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved. Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Alpha TAU Killing Tumors With Highly Targeted Alpha Radiation
Radiation is commonly employed in hospitals around the world to treat tumors, typically using gamma ray beams of high energy photons, with a relatively long range, that penetrate all the tissues on the way to and from the tumor. This leads to substan...
Source: Medgadget - March 2, 2023 Category: Medical Devices Authors: Medgadget Editors Tags: Exclusive Oncology Radiation Oncology TelAvivUni Source Type: blogs

Terahertz Spectroscopy to Assess Severity of Skin Burns
Scientists at Stony Brook University in New York have developed a hand-held scanner that uses terahertz time-domain spectroscopy and neural network data analysis to non-invasively assess the severity of skin burns. At present, it is difficult to visu...
Source: Medgadget - February 9, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Dermatology Medicine Radiology Surgery stonybrooku Source Type: blogs

Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, October 24th 2022
This study shows the uncoupling of lifespan and healthspan parameters (aerobic fitness and spontaneous activity) and provides new insights into SIRT3 function in CR adaptation, fuel utilization, and aging. HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People https://www.fightaging.org/archives/2022/10/hdl-level-age-and-smoking-are-the-largest-determinants-of-mortality-risk-in-old-people/ An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise ...
Source: Fight Aging! - October 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Notes from the Rejuvenation Startup Summit, Held in Berlin in October 2022
We presented recent results showing reversal of liver inflammation and fibrosis in NASH model mice, and noted that we're raising funds to start our clinical development program leading to human trials. Therapies to reverse atherosclerosis progression will follow shortly on the heels of this work on NASH. Robin Mansukhani of Deciduous Therapeutics discussed their approach to immune system modulation via small molecules, training invariant natural killer cells to attack senescent cells. The point was made that engaging the immune system may be a way to work around many of the present unknowns regarding senescent cell ...
Source: Fight Aging! - October 19, 2022 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

TLC Todd-versations: Todd Linsky in Conversation with Dr. Alan Greene
Todd Linsky, a food and organic industry veteran, hosts the podcast Todd-versations. He interviews guests from around the globe — influencers, leaders, and innovators in their respective fields. In this episode, Todd and Dr. Greene discuss the pediatric roots of longevity, the importance of nutrition in health, Dr. Greene’s reasons for creating DrGreene.com, his next projects, and a whole host of side topics. Transcript of Todd-versation Podcast with Todd Linsky and Dr. Greene 0:00 this conversation is brought to you in part by Calavo Growers the family of fresh! 0:19 hey there everybody good ...
Source: Conversations with Dr Greene - October 6, 2022 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog Source Type: blogs

Amazing Technologies Changing The Future Of Dermatology
Smart algorithms will soon diagnose skin cancer, dermatologists consult patients online, and 3D printers will print out synthetic skin to fight tissue shortages. There is a lot going on in dermatology, and medical professionals should prepare in time for the technological changes before they start swiping through the specialty. Let’s start by familiarising ourselves with the most amazing technologies changing the future of dermatology! Skin cancer is too common According to statistics from the WHO, currently, some 1.5 million non-melanoma skin cancers and 325,000 melanoma skin cancers occur globally each year. Data...
Source: The Medical Futurist - August 4, 2022 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Telemedicine & Smartphones 3d printing AI artificial intelligence digital Healthcare Innovation nanotechnology Personalized medicine robotics wearables GC1 dermatology Source Type: blogs

Fight Aging! Newsletter, May 30th 2022
In conclusion, fisetin supplementation may be a novel strategy to target excess cellular senescence and thereby reduce mitochondrial ROS to improve NO-mediated endothelial function with aging. Exercise Upregulates BDNF Expression to Promote Dopamine Release and Brain Function https://www.fightaging.org/archives/2022/05/exercise-upregulates-bdnf-expression-to-promote-dopamine-release-and-brain-function/ Researchers have in the past shown that exercise results in greater amounts of BDNF, which in turn promotes neurogenesis. Here, this line of research is extended to show that exercise results in an increas...
Source: Fight Aging! - May 29, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far. Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/ In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and here...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Handheld Photoacoustic Device for Lymph Node Assessment
Researchers at Pohang University of Science & Technology in South Korea have developed a handheld photoacoustic device that can locate sentinel lymph nodes near the armpit. The technology could help clinicians to locate the correct lymph node fro...
Source: Medgadget - September 23, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Surgery Source Type: blogs