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Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ultrasound-Equipped Bra Monitors for Breast Cancer
Researchers at MIT have developed a wearable ultrasound system that is intended to allow women at high risk of breast cancer to perform an ultrasound scan on themselves at home, and may also let patients with early-stage malignancy or suspicious lesi...
Source: Medgadget - August 22, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Diagnostics Radiology Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Hopes and Questions raised by Alzheimer ’s drug Leqembi (lecanemab)
The FDA has approved Leqembi, the first disease-modifying treatment for early-stage Alzheimer’s and a precursor condition, mild cognitive impairment. Medicare has said it will pay for the therapy. Medical centers across the country are scrambling to finalize policies and procedures for providing the medication to patients, possibly by summer’s end or early autumn.
It’s a fraught moment, with hope running high for families and other promising therapies such as donanemab on the horizon. Still, medical providers are cautious. “This is an important first step in developing treatments for complex neurodegenerative disea...
Source: SharpBrains - August 17, 2023 Category: Neuroscience Authors: Judith Graham at Kaiser Health News Tags: Brain/ Mental Health cognition early-stage Alzheimer’s Eisai FDA lecanemab Leqembi Medicare mild-cognitive-impairment Source Type: blogs
THCB 20th Birthday Classic: As I’ve always suspected, Health Care = Communism + Frappuccinos
By MATTHEW HOLT
Our 20th birthday continues with a few classics coming out. Back in 2005 I was really cutting a lyrical rug, and would never miss a chance to get that Cambridge training in Marxism into use. This essay about whether health care should be a public or private good has always been one of my favorites, even if I’m not sure Starbucks is still making Frappuccinos. And 18 years later the basic point of this essay remains true, even if many of you will not have a clue who Vioxx or Haliburton were or why they mattered back then!
Those of you who think I’m an unreconstructed commie will correctly suspec...
Source: The Health Care Blog - August 15, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Matthew Holt Communism Frappuccinos Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't n...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Biomaterial Injection Combines T Cell and Cancer Vaccine Treatments
Researchers at the Harvard Wyss Institute have developed an anti-cancer biomaterial treatment that combines adoptive T cell therapy and cancer vaccine technology to treat solid tumors. The researchers have called their technique SIVET, which is short...
Source: Medgadget - August 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology harvard wyssinstitute Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Altis Labs Raises US $6 Million in Seed Funding Co-Led by Debiopharm and Benchstrength to Advance AI Platform for Clinical Trials
Debiopharm Innovation Fund and Benchstrength Co-Lead Seed Funding Round Supporting Altis’ AI-Powered Imaging Biomarker Platform
Altis Labs, Inc. (Altis), the computational imaging company accelerating clinical trials with artificial intelligence, today announces the closing of its US $6 million seed financing. Benchstrength and Debiopharm Innovation Fund co-led the round with participation from strategic angels including Doug Foster, the former CEO at digital health company Verana Health, and Richard Gliklich, MD, the Founder and CEO at real-world data company OM1.
“We are thrilled to partner with Benchstrength and Deb...
Source: EMR and HIPAA - July 14, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Altis Labs Bayer Pharmaceuticals Benchstrength Carolina Haefliger MD Debiopharm Debiopharm Innovation Fund Doug Foster Felix Baldauf-Lenschen Health IT Funding Health IT Fundings Health IT Investment Source Type: blogs
Psychedelic Science 2023 – Full Conference Review
In June I attended the Psychedelic Science 2023 conference at the Colorado Convention Center in Denver. We were told this was the largest psychedelic-related gathering in the history of the planet, attracting about 12,000 attendees and 500 speakers. In this post I’ll share about my experiences and insights from the conference.
Here’s a pic from inside the Bellco Theater where the main keynotes were held.
The Colorado Convention Center is sizable, and sessions were spread across many different rooms. Even though I didn’t do extra exercise on this trip, I was typically hitting about 1000 calories ...
Source: Steve Pavlina's Personal Development Blog - July 7, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Health Lifestyle Source Type: blogs
How Automation Can Help Ease Healthcare Worker Burnout
The following is a guest article by Anna Twomey, Senior Director, Healthcare Providers – Americas at SS&C Blue Prism
With rising staffing shortages and burnout among healthcare workers, digital transformation will be key to overcoming these challenges and protecting patient care. It’s estimated that the U.S. could see a shortage of up to 124,000 physicians by 2033 and will need to hire at least 200,000 nurses per year to meet increased demand and to replace retiring nurses. The healthcare worker burnout crisis in this country began before the COVID-19 pandemic, but the public health emergency m...
Source: EMR and HIPAA - June 28, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Anna Twomey BPM Business Process Management Digital Transformation EHR Healthcare Automation Healthcare Burnout IA Intelligent Automa Source Type: blogs
What goes on in the brain matters
I am the first to say (quite loudly at times) that pain is a whole person experience. I say this because my experience of pain is mine and utterly unable to be shared in all its complexity. The only way other people know about my pain is through my actions – both involuntary and voluntary. And even then: the way I express myself differs depending on my social context, my mood, my goals, and what I think my pain represents. Yet when I’m asleep, I don’t have pain, when I have anaesthetic for my colonoscopy, I don’t have pain – so what goes on in my brain is kinda important.
Now there have bee...
Source: HealthSkills Weblog - June 25, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Pain conditions Research Therapeutic approaches Source Type: blogs
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
