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Even Eliminating the Top Four Causes of Age-Related Death Gains Few Years of Life
Aging is a general process of deterioration, and any specific age-related disease, even one of the fatal conditions, is only a very narrow manifestation of that broad deterioration. It is a fantasy to think that any one specific age-related condition can be cured, entirely removed from the full spectrum of damage that is aging, in isolation, and without impact to the rest of aging. The only way to cure an age-related condition is to repair all of the forms of cell and tissue damage that cause it, and each type of damage has widespread effects beyond its contribution to any one named disease. Aging is treated all at once, o...
Source: Fight Aging! - November 28, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Mrs. Verma Goes to Washington
By ANISH KOKA MD
Seema Verma, the Trump appointee who runs Medicare, has had an active week. The problem facing much-beloved Medicare is one that faces every other government-funded healthcare extravaganza: it’s always projected to be running out of money. Medicare makes up 15% of the total federal budget. That’s almost $600 billion dollars out of a total federal outlay of $4 Trillion dollars. The only problem here is that revenues are around $3.6 trillion. We are spending money we don’t have, and thus there there is constant pressure to reduce federal outlays.
This is a feat that appears to be legislatively im...
Source: The Health Care Blog - November 15, 2018 Category: Consumer Health News Authors: anish_koka Tags: Health Policy Hospitals Medicare Physicians Anish Koka Government Health care spending Source Type: blogs
Fight Aging! Newsletter, October 29th 2018
This study shows that some genetic changes linked to cancer are present in surprisingly large numbers of normal cells. We still have a long way to go to fully understand the implications of these new findings, but as cancer researchers, we can't underestimate the importance of studying healthy tissue."
Early Onset of Menopause Correlates with Shorter Life Expectancy
https://www.fightaging.org/archives/2018/10/early-onset-of-menopause-correlates-with-shorter-life-expectancy/
Aging is a phenomenon affecting all organs and systems throughout the body, driven by rising levels of molecular damage. The variat...
Source: Fight Aging! - October 28, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Are menopause and high cholesterol related?
Discussions with Physicians) online on behalf of Kowa Pharmaceuticals America, Inc. from July 7 to August 4, 2017, among 5,014 U.S. adults age 45 or older who had been diagnosed with high cholesterol and had used a statin to treat high cholesterol. This online survey is not based on a probability sample and therefore no estimate of theoretical sampling error can be calculated.
The post Are menopause and high cholesterol related? appeared first on Embrace Your Heart.
Source: Embrace Your Heart Wellness Initiative - October 1, 2018 Category: Cardiology Authors: Eliz Greene Tags: Award Winning Blog Heart Disease Risk Factors Heart Health Menopause and Heart Health Women's Wellness Take Cholesterol To Heart Source Type: blogs
Fierce Urgency of Now: Family Caregivers and the Future That Is Upon Us
Just before Mother’s Day, I was a guest on an Al-Jazeera news segment focused on the challenges of aging in America. It was my first-ever news appearance, and, later, I proudly showed a recording to my adult daughters when they came by to visit. The segment included a look at how elders are navigating the shoals of old age, sickness, and financial insecurity—a future millions of face, and all of us deny.
One segment featured a mid-life African American woman who had abandoned her retirement dreams to care for her mother, who has Alzheimer’s. As the woman fixed her mother’s wisps of hair, both daughters turned to me...
Source: Disruptive Women in Health Care - September 25, 2018 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Uncategorized Source Type: blogs
Aspirin for primary prevention of cardiovascular disease, part 2
Well, it seems as though not even a week can go by without more data on aspirin! I recently reviewed the ARRIVE trial and the implications for primary prevention — that is, trying to prevent heart attacks and strokes in otherwise healthy people. Since then, yet another large clinical trial — the ASPREE study — has come out questioning the use of aspirin in primary prevention. Three articles pertaining to this trial were published in the prestigious New England Journal of Medicine, which is an unusual degree of coverage for one trial and highlights its immediate relevance to clinical practice.
Aspirin still strongly i...
Source: Harvard Health Blog - September 25, 2018 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Heart Health Prevention Source Type: blogs
Fight Aging! Newsletter, September 17th 2018
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - September 16, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Upload Your DNA to a Web Site to Generate Risk Scores for Five Diseases
I have posted a few notes about predictive diagnostic algorithms (see:An Algorithm Using Medical Record Data Predicts Risk for Parkinson's Disease;Should the Work Product of"Non-Explainable" Medical Algorithms Be Ignored) and disease risk scores (see:Genetic Risk Scores: Ready for Inclusion in the Medical Record?). Using AI techniques, researchers at Massachusetts General are developing a web site that will display a risk score for five common diseases after consumers upload their DNA to the site (see:Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA). The algorithm takes into account mil...
Source: Lab Soft News - August 28, 2018 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Genomic Testing Healthcare Information Technology Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Medical Research Source Type: blogs
True Confessions On Why I Prescribe Things Without ' Evidence '
by Drew RosielleWe have a ' required reading ' list for our fellowship, which includes a bunch of what I think are landmark or otherwise really important studies. One of them is thisvery well done RCT of continuous ketamine infusions for patients with cancer pain, which showed it to be ineffective (and toxic).We also recently have seen another high-quality study published with negative results for ketamine. This was a Scottish, multi-center, randomized, placebo-controlled, intention-to-treat, and double-blinded study oforal ketamine for neuropathic pain in cancer patients. The study involved 214 patients, 75% of whom were ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - July 6, 2018 Category: Palliative Care Tags: fatigue ketamine methylphenidate neuropathic pain research research issues rosielle The profession Source Type: blogs
The Evidence Crisis: Causal Inference – Don ’ t be a chicken (Part 3)
By ANISH KOKA
Part 1
Part 2
Physicians have been making up numbers longer than people have been guessing weights at carnivals. How much does this statin lower the chances of a heart attack? How long do I have to live if I don’t get the aortic valve surgery?
In clinics across the land confident answers emerge from doctors in white coats. Most of the answers are guesses based on whatever evidence about the matter exists applied to the patient sitting in the room. The trouble is that the evidence base used to be the provenance of experts and anecdotes that have in the past concluded leeches were good for pneumonia...
Source: The Health Care Blog - June 29, 2018 Category: Consumer Health News Authors: anish_koka Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, May 28th 2018
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years.
The researchers analysed six factors that could impact on...
Source: Fight Aging! - May 27, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 21st 2018
In conclusion, the connection between DNA damage and aging is emphasized by the secretion of senescence-associated proteins during cellular senescence, a phenotype which is activated by DNA damage and is common for both human and mice. Though much progress has been achieved, full understanding of these mechanisms has still a long way to go.
XPO1 as a Novel Target for Therapies to Enhance Autophagy
https://www.fightaging.org/archives/2018/05/xpo1-as-a-novel-target-for-therapies-to-enhance-autophagy/
Autophagy is the name given to a collection of cellular housekeeping processes that recycle damaged and un...
Source: Fight Aging! - May 20, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 7th 2018
The objective here is a set of tests that (a) match up to the expected outcome based on human trials of mitochondrially targeted antioxidants, and (b) that anyone can run without the need to involve a physician, as that always adds significant time and expense. These tests are focused on the cardiovascular system, particularly measures influenced by vascular stiffness, and some consideration given to parameters relevant to oxidative stress and the development of atherosclerosis.
A standard blood test, with inflammatory markers.
An oxidized LDL cholesterol assessment.
Resting heart rate and blood pressure.
Heart r...
Source: Fight Aging! - May 6, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ignorance based cardiology : What is the relationship between blood cholesterol and plaque cholesterol ?
Hyperlipidimia is one of the well-known coronary risk factor.Serum cholesterol ( Various fractions ) levels are measured to represent that risk. Epidemiologically ,it does a perfect job , however , the fact is , circulating lipids has little correlation with the lipids that’s deposited in the vessel wall.
Time and again , we have proven this as severity of CAD has little to do with the absolute levels of lipid levels.The number volume of plaques , the thickness of lipid core, and degree of vulnerability show poor correlation with circulating lipid levels than what we would expect.It tempts us to make a st...
Source: Dr.S.Venkatesan MD - May 5, 2018 Category: Cardiology Authors: dr s venkatesan Tags: Cardiology -Mechnisms of disease dyslipidemia hyperlipidemia stains and ldl cholesterol crystalisation plaque lipid vs serum lipid] relationship between serum lipid and plaque cad burden relationship between serum lipids and plaque lipid con Source Type: blogs
