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Enhanced Autophagy as a Potential Basis for Treating Neurodegenerative Conditions
The consensus in the scientific community is that useful therapies can be built on the safe enhancement of autophagy. This has been the case for many years now, but unfortunately, and despite a broad and ongoing range of research initiatives, there has yet to be any significant progress on the path from laboratory to clinic in this part of the field. Even simple, easily explained adjustments to the operation of metabolism turn out to be involved and costly projects. They take a long time to come to fruition, and when considered individually have poor odds of success. Look no further than the past two decades spent in searc...
Source: Fight Aging! - May 9, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

A Health Plan CEO Daydreams
By MICHEL ACCAD, MD Jim was at his desk, looking weary. The last few weeks had been brutal.  Despite working twelve-hour days, he felt that he had little to show for it.  His annual board meeting was to take place the next day, and he expected it to be tense. With a replacement bill for the ACA about to be voted on, and with Trump in the White House, the situation seemed particularly precarious.  The board members had asked him to present a contingency plan, in case things in DC didn’t go well. As CEO of a major health insurance company, Jim was well aware that business as usual had become unsustainable in his l...
Source: The Health Care Blog - May 4, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized AHCA health reform MICHEL ACCAD repeal and replace Source Type: blogs

Four Crucial Questions To Ask Your Doctor
I am seeing an increasing number of patients who did not know they had a choice about taking a medicine or having a procedure. Why did you have that heart cath? A: My doctor said I should. Why are you on that medicine? A: My doctor prescribed it. It’s time we re-review the basic four questions you should ask your doctor. I wrote about this in April of 2015 for WebMD. Here is 2017 update: 1. What are the odds this test/medicine will benefit me? Medical decisions are like gambles. Benefit is not guaranteed. In my field, catheter ablation of supraventricular tachycardia (SVT) has a success rate approaching 99%, but th...
Source: Dr John M - April 17, 2017 Category: Cardiology Authors: Dr John Source Type: blogs

Calcium Scan and Subtractive Medicine
By SAURABH JHA MD Being a radiologist, I rarely speak to patients, but I was asked to counsel Mrs. Patel (not her real name, so calm down HIPAA totalitarians), who was worried about the risks of radiation from cardiac calcium CT scan. Because of her risk factors for atherosclerosis, her cardiologist wanted her to take statins for primary prevention, but she was reluctant to start statins. They eventually reached a truce. If she had even a speck of calcium in her coronary arteries she would take statins. If her calcium score was zero she wouldn’t. This type of shared decision making is the most frequent reason why cardiol...
Source: The Health Care Blog - April 3, 2017 Category: Consumer Health News Authors: at RogueRad Tags: Patients Small Practice Source Type: blogs

Health should be FREE
Imagine that you receive a notice in the mail stating “In order to maintain your freedom of speech, you will be billed $10,000 per year.” You would be—understandably—outraged. Freedom of speech in America is precious, something Americans have fought wars to defend. We view free speech as a basic right, no big check to write in order to maintain it. It should be free and available to everyone regardless of religion, color, political leanings, or income. I believe that same principle should apply to health. Being healthy means living free of common chronic health conditions such as high cholesterol, high blood sugars...
Source: Wheat Belly Blog - March 31, 2017 Category: Cardiology Authors: Dr. Davis Tags: Undoctored crowd wisdom health free Healthcare System predatory wheat belly Source Type: blogs

Fight Aging! Newsletter, March 27th 2017
In conclusion, DNAm of multiple disease-related genes are strongly linked to mortality outcomes. The recently established epigenetic clock (DNAm age) has received growing attention as an increasing number of studies have uncovered it to be a proxy of biological ageing and thus potentially providing a measure for assessing health and mortality. Intriguingly, we targeted mortality-related DNAm changes and did not find any overlap with previously established CpGs that are used to determine the DNAm age. Our findings are in line with evidence, suggesting that DNAm involved in ageing or health-related outcomes are mostly...
Source: Fight Aging! - March 26, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Law of Diminishing Returns of Ethicism
SAURABH JHA MD Many allege that the FIRST trial, which randomized surgical residencies to strict versus flexible adherence to duty hour restrictions, was unethical because patients weren’t consented for the trial and, as this was an experiment, in the true sense of the word, consent was mandatory. The objection is best summarized by an epizeuxis in a Tweet from Alice Dreger, a writer, medical historian, and a courageous and tireless defender of intellectual freedom. @RogueRad @LVSelbs @ethanjweiss @Skepticscalpel Consent to experimentation. Consent. Consent. Am I not being clear? — Alice Dreger (@AliceDreger) Nov...
Source: The Health Care Blog - March 20, 2017 Category: Consumer Health News Authors: at RogueRad Tags: Uncategorized Source Type: blogs

The scary evolution of direct-to-consumer advertising
One night in 1997, as Americans watched Touched by an Angel they were touched by something else unexpected: an ad for a prescription allergy pill called Claritin, sold directly to patients. Prescription drugs had never been sold directly to the public before — a marketing tactic called direct-to-consumer or DTC advertising. How could average people, who certainly had not been to medical school, know if the medication was appropriate or safe without a doctor’s recommendation? Soon, ads for Meridia, Propecia, Singulair, Paxil, Prozac, Vioxx, Lipitor, and Viagra followed — exhorting patients to “ask their doct...
Source: Kevin, M.D. - Medical Weblog - March 17, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/martha-rosenberg" rel="tag" > Martha Rosenberg < /a > Tags: Conditions Cancer Source Type: blogs

Are You Consuming Enough Omega-3 Fatty Acids?
Infrequent consumption of seafood, aversion to organ meats, and over-reliance on processed omega-6 oils in foods have led to deficient levels of omega-3 fatty acids in most people today. The seeds of grasses, with all their absorption-blocking and inflammatory effects just add to the problem. Once grains are removed, omega-3 fatty acid absorption may improve. – Tweet this! Intake typically remains low for most people and supplementation is necessary to achieve healthy blood levels. The omega-3 fatty acids from fish oil accelerate the clearance of fatty acids from the bloodstream and keep levels lower. Cholesterol panel...
Source: Wheat Belly Blog - November 8, 2016 Category: Cardiology Authors: Dr. Davis Tags: Dr. Davis News & Updates Nutritional deficiencies Nutritional supplements Omega-3 Wheat Belly Lifestyle Wheat Belly Success Stories gluten Weight Loss Wheat Belly Total Health Source Type: blogs

Low levels of HDL (the “good” cholesterol) appear connected to many health risks, not just heart disease
This study found that lower HDL cholesterol levels were associated with a higher risk of death from cardiovascular causes, as prior studies have shown. However, there was also a higher risk of death from cancer and other causes compared with those having average levels of HDL cholesterol. That finding makes it seem as though low HDL cholesterol isn’t just predicting cardiovascular death — which might make sense if it is really causing heart disease — but it is also predicting cancer deaths and other causes of death. And there is not a good biological explanation for why a low HDL cholesterol level should do that. The...
Source: Harvard Health Blog - November 2, 2016 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Health Heart Health Prevention Tests and procedures Source Type: blogs

Aging, Just Another Disease
Aging is nothing more than a medical condition, and one that should be treated. There is a considerable amount of residual inertia on this topic, however, many people yet to be convinced that aging is anything other than set in stone, or that it is desirable to prevent the suffering and death caused by aging. At the large scale and over the long term, funding for medical research and pace of progress is determined by public support for the goals of that research. This is why we need advocacy, fundraising, and continued public discussion on the plausibility and desirability of building therapies capable of treating the caus...
Source: Fight Aging! - November 2, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Statin Wars: Less-is-More versus Unlimited Medicine  
By SARAH JHA, MD It is the beauty of evidence-based medicine (EBM) that a scientist can at once be a Pope and a Galileo. His transmutation is as effortless as it is discretionary. If you think you’ve met Galileo – a rebel, a free thinker, a rocker of the establishment – the following week he is a Pope, castigating detractors, censoring critics, and celebrating uniformity. He changes by a roll of the dice. His change is decided by a quirk in hypothesis-testing known as statistical significance. If the p value is 0.051 he is Galileo, if the p value is 0.049 he becomes the cardinal. He is one day a raging skepti...
Source: The Health Care Blog - September 20, 2016 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

Oh So Quietly, Evidence of Bad Health Care Corporate Leadership Accumulates - Three AstraZeneca Settlements
While the news media is distracted by seemingly more spectacular issues, we hear the steady drip, drip, drip oflegal cases suggesting just how systemically bad the leadership of big health care organizations is.  From February 2015 to now, for example, there have been three cases involving multinational pharmaceutical giant AstraZeneca.Settlement of Allegations of Kickbacks to Give AZ Drugs Preferred Status in FormulariesFirst, in February 2015, reported in most detail by Ed Silvermanin the Wall Street Journal,AstraZeneca has agreed to pay the federal government $7.9 million to settle allegations the drug maker paid k...
Source: Health Care Renewal - September 8, 2016 Category: Health Management Tags: AstraZeneca bribery deception impunity kickbacks legal settlements Source Type: blogs

Dear Heart failure patients . . .Wishing you all a controlled weight loss and a happy life !
Cardiac failure is defined as a clinical syndrome where the cardiac output is inadequate and fails to fulfill the metabolic demands of body  or its able to do so, only  at a raised filling pressure, causing the classical symptoms of exertional dyspnea. Consider this simple equation, A 70 kg normal human requires an EF of 60 %  to supply blood  to his total body mass. If his EF falls to 30 % , certainly he is going to  struggle with reduced cardiac  output by 50 %. Now , theoretically if he loses his weight by 50 % (70 to 35 kg ) in-proportion to the loss in EF, . . . isn’t likely , he goes back to the original...
Source: Dr.S.Venkatesan MD - August 16, 2016 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized heartfailure and obesity wieght loss in cardiac failure WISH study Source Type: blogs

Health Expenditure Projections: When Does ‘New’ Become ‘Normal’?
The Centers for Medicare and Medicaid Services (CMS) has released its latest forecast of medical spending for the next decade. The headline number is that medical care as a share of gross domestic product (GDP) is expected to increase from its current 17.5 percent of GDP to 20.1 percent by 2025, resuming an upward increase after a several year slowdown. Forecasting is an inexact science. To make guesses about the future, analysts typically examine the past. The history of medical spending can roughly be described using Fuchs’ law: medical spending increases have exceeded GDP increases by about 2.5 percentage points annua...
Source: Health Affairs Blog - July 13, 2016 Category: Health Management Authors: David Cutler Tags: Costs and Spending Featured Insurance and Coverage Medicaid and CHIP Medicare Payment Policy ACA ACOs Alternative Payment Models MACRA spending projections Source Type: blogs