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Cancer Survivors Exhibit Greater Risk of New Cancers and Higher Mortality Due to those Cancers
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - December 29, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Discussing the Accelerated Aging of Cancer Survivors
It is well known that cancer survivors who underwent chemotherapy or radiotherapy exhibit a shorter life expectancy, greater chance of unrelated cancer incidence, and greater risk of age-related disease. The most reasonable hypothesis at present is that these undesirable outcomes are the result of an increased burden of senescent cells. Historically, cancer treatments have been in large part designed to force cancerous cells into senescence, those that are not killed outright by the therapy. Since these cancer therapies are toxic to cells, they also tend to cause off-target cell death and senescence. It is possible that si...
Source: Fight Aging! - July 12, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Worse Functional Decline with Age is Observed in Cancer Survivors
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Source: Fight Aging! - August 12, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Poor Quality Sleep: A Silent Source of Disability in Breast Cancer
The post below ran on Huffington Post Healthy Living on May 13. It is authored by Hrayr Attarian, MD, FACCP, FAASM, Member of the Society for Women’s Health Rearch Network on Sleep and Associate Professor of Neurology, Northwestern University, Circadian Rhythms and Sleep Research Lab for the Society for Women’s Health Interdisciplinary Network on Sleep.
Poor quality sleep is a major contributor to reduced quality of life and can have a negative impact on mood and energy, cognition, metabolic and immunological function, as well as lead to weight gain [3].
Sleep-related complaints are quite common in women with b...
Source: Disruptive Women in Health Care - July 14, 2015 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Cancer Source Type: blogs
Lung-MAP--A Bold Initiative To Find New Treatments For Squamous Cell Lung Cancer--Launches Today
Today marks a major step forward in cancer clinical trials and drug development with the launch of the Lung-MAP protocol to evaluate new treatments for squamous cell lung cancer, a common cancer which has proven resistant to the standard drugs currently available. In response to this genuine unmet need, Lung-MAP has been designed to move new therapies more quickly from the laboratory to the bedside of patients afflicted with this serious disease and few options available.
Many--including present company--have written about the need to improve this process. We are in a new era of cancer drug development, spearheaded by our ...
Source: Dr. Len's Cancer Blog - June 16, 2014 Category: Cancer Authors: Dr. Len Tags: Access to care Cancer Care Lung Cancer Medications Research Tobacco Treatment Source Type: blogs
Blogging About Breast Cancer – A New Therapy?
It has been a tough year with my mom passing away in June and recently another member of the family has had serious health problems. It has helped me a lot to share thoughts and feelings with friends and family through social media while I was dealing with the loss of my mom and now this recent development. The more people I talk to about tweeting and face book, the more I realize how supportive social media can be. Blogging about breast cancer can be therapy.
I benefitted all these years from blogging about my experience with breast cancer. I definitely find that sharing openly on the web helps keeps me sane about my th...
Source: Life with Breast Cancer - August 27, 2013 Category: Cancer Authors: Kathy-Ellen Kups, RN Tags: Breast Cancer blogging breast cancer therapy social media Source Type: blogs
Cancer Survivors Exhibit a Significantly Higher Risk of Cardiovascular Disease
The dominant cancer therapies of chemotherapy and radiotherapy have not yet been replaced by immunotherapies for more than a handful of cancer types. These classes of therapy produce a significantly increased burden of senescent cells in patients; one of the goals of cancer therapy is to drive cancerous cells into senescence, those that cannot be killed. These additional senescent cells in turn accelerate the progression of degenerative aging. The advent of senolytic therapies to clear senescent cells from aged tissues will make a sizable difference to these patients. More effort should be undertaken today to enable patien...
Source: Fight Aging! - July 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Present Standard Cancer Therapies Increase Biological Age
The current standard treatments for cancer, chemotherapy and radiotherapy, are quite unpleasant and harmful; no-one would voluntarily undergo them given a better alternative. In fact, treatment makes people physically older, accelerating the processes of aging. There is evidence to suggest that this is due to an added burden of senescent cells. Cells become senescent in response to damage or a toxic environment, and there is plenty of that going around in any earnest attempt to treat cancer with radiation or chemical agents; in fact, many cancer therapies are intended to aggressively induce senescence in tumor cells.
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Source: Fight Aging! - December 20, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reconceptualizing Health and Health Care: Why Our Cancer Care Delivery System Is In Crisis
Cancer Care System in Crisis
Americans fear cancer. In a poll for MetLife, when participants were asked which major disease they feared most, 41 percent said cancer, 31 percent said Alzheimer’s disease, and small percentages of other respondents said other diseases. Not surprisingly, The National Institutes of Health has a budget allocation of $4.9 billion for 2014 to The National Cancer Institute, far more than any other Institute and over 25 percent of the NIH’s total funding to study organ-based diseases ($19.2 billion).
Despite this longstanding commitment to cancer research, the Institute of Medicine (IOM) reporte...
Source: Health Affairs Blog - September 23, 2014 Category: Health Management Authors: Carolyn Payne and William Dale Tags: All Categories Chronic Care End-of-Life Care Health Care Costs Health Care Delivery Long-Term Care Source Type: blogs
The Potential for Senolytics and Other Senotherapies to Improve Outcomes in Cancer Therapies
Cellular senescence is a double-edged sword in the matter of cancer. The state of senescence is a growth arrest coupled with pressure to self-destruct and a call to the immune system to destroy the senescent cell. As such it serves as a first line of defense against cancer. Most cancer treatments force large numbers of cancerous cells into senescence, in addition to causing outright cell death, shutting down their ability to replicate. Unfortunately, the presence of too many senescent cells is harmful in and of itself, as their signaling produces chronic inflammation, disrupts tissue function throughout the body, and makes...
Source: Fight Aging! - January 28, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Past Progress Towards Control of Cancer Has Been Slow, Steady, and Incremental
Mortality rates for cancer have diminished slowly and steadily over the past few decades. This is a matter of prevention on the one hand and improvements in early detection of cancer on the other. When caught early enough, even comparatively crude approaches to therapy have a decent chance of controlling and eliminating the cancer. This trend will no doubt continue, but the more rapid, more effective progress that we'd like to see will only emerge given the advent of universal cancer therapies, those that strike at mechanisms, such as telomere lengthening, that are shared by many or all cancers. That is a plausible goal fo...
Source: Fight Aging! - January 23, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The One-Two Punch of Cancer Therapies Plus Senolytics
There is considerable enthusiasm in the cancer research community regarding the prospects for improved patient outcomes via the use of senolytics to clear senescent cells from tissues. It seems fairly clear that an increased burden of senescent cells results from the use of traditional cancer therapies, chemotherapy and radiotherapy, and that this is most likely the cause of a large fraction of the greater risk of age-related disease and shorter remaining life expectancy in cancer survivors. Undergoing those forms of cancer therapy is literally a matter of signing up for accelerated aging - and still the preferable alterna...
Source: Fight Aging! - September 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Breast Cancer Patients Deserve Better: Policy Must Support Innovation
October is National Breast Cancer Awareness Month. During this time, those of us in the advocacy community take stock of the millions of lives that have been affected forever by this dreadful disease. Breast cancer ranks second as a cause of death in women. Each year, about 230,000 women, and more than 2,000 men, receive a diagnosis of invasive breast cancer.
Cancer survivors, caregivers and doctors tell us that the most powerful weapons against breast cancer are early detection and the elimination of “trial and error” therapies. This is accomplished by pinpointing the most effective treatment options immediately after...
Source: Disruptive Women in Health Care - October 31, 2013 Category: Health Medicine and Bioethics Commentators Authors: dw at disruptivewomen.net Tags: Uncategorized Source Type: blogs
Further Evidence for Cancer Treatments to Accelerate Aging
People who have undergone chemotherapy or radiotherapy suffer a reduced life expectancy and increased risk of suffering other age-related conditions even when the cancer is defeated. These cancer therapies produce large numbers of senescent cells, both as a result of their toxicity and because they force cancerous cells into senescence. It is quite likely that this is the primary mechanism by which successful cancer treatments nonetheless shorten later lifespan. This could be considered a true form of accelerated aging, as the accumulation of senescent cells is one of the root causes of aging. These cells secrete signals t...
Source: Fight Aging! - November 29, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cancer Survivors have Double the Risk of Suffering a Later Stroke
We present a contemporary analysis of risk of fatal stroke among more than 7.5 million cancer patients and report that stroke risk varies as a function of disease site, age, gender, marital status, and time after diagnosis. The risk of stroke among cancer patients is two times that of the general population and rises with longer follow-up time. The relative risk of fatal stroke, versus the general population, is highest in those with cancers of the brain and gastrointestinal tract. The plurality of strokes occurs in patients older than 40 years of age with cancers of the prostate, breast, and colorectum. Patients of any ag...
Source: Fight Aging! - December 9, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
