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Total 36 results found since Jan 2013.

mRNA Vaccines: From Tackling Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.  What is mRNA? In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs

mRNA Vaccines: From Tackling A Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.  What is mRNA? In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs

Fight Aging! Newsletter, January 28th 2019
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - January 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Yet More Breakthroughs in Science and Technology
Here is yet another installment in the series on incremental change in science and technology. As ever, check out data on the improving state of the world at www.humanprogress.org. Prawn Sex-Change Boosts Yields    Male prawns grow faster and get to be 60% larger than female prawns. As such, they are more economically valuable. By slicing the prawn genome, scientists from the Ben Gurion University found, it is possible to generate all-male populations of prawns. In trials, female prawns were injected with a molecule that silenced certain genes thus allowing for all-male prawn yields. This method eliminates the need f...
Source: Cato-at-liberty - October 23, 2015 Category: American Health Authors: Marian L. Tupy Source Type: blogs

Last Christmas – a short story
Last Christmas by David Bradley (PDF/Kindle version here) Funnily enough, it was four years to the day since the fourth variant had emerged. So, it was Christmas Day. Four years since the death toll passed 200 million. What a gift. Four years since the last dying embers of the theory of herd immunity had burned out and even the rich and the beyond-rich were suffering. Four years. It’s hard to believe. What started as a very localised outbreak, with a mere handful of hospitalisations had quickly thrown the global community into panic and ultimately pandemic. The present that keeps on giving. Each genetic mutation unwrappi...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 29, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

Last Christmas – a Xmas Gothic
Last Christmas by David Bradley (PDF/Kindle version here) Funnily enough, it was four years to the day since the fourth variant had emerged. So, it was Christmas Day. Four years since the death toll passed 200 million. What a gift. Four years since the last dying embers of the theory of herd immunity had burned out and even the rich and the beyond-rich were suffering. Four years. It’s hard to believe. What started as a very localised outbreak, with a mere handful of hospitalisations had quickly thrown the global community into panic and ultimately pandemic. The present that keeps on giving. Each genetic mutation unwrappi...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 29, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

PhRMA Report: Over 5400 Medicines in Development and 70% are First in Class
According to report released by PhRMA, companies have more than 5,400 medicines in development globally, and more than 70% of therapies in the pipeline are potentially first-in-class and could offer patients new treatment options, and a notable number of potential therapies target diseases with limited treatment options such as ALS and rare diseases.  A breakdown of their report offers insight into the various medicines in development for different diseases and populations.    Older Americans  America’s biopharmaceutical research companies are developing 465 new medicines that target the 10 leading chronic conditi...
Source: Policy and Medicine - April 24, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs

Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is t...
Source: Fight Aging! - January 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, April 25th 2016
This study offers one useful data point, as the authors describe a genetic alteration that can boost the supply of new immune cells in old mice. The decline in that supply with age is one of the factors leading to poor immune function - and that means more than just vulnerability to infections, as the immune system is also responsible for destroying potentially cancerous and senescent cells, as well as clearing out forms of damaged proteins and unwanted metabolic waste. Various possibilities for increasing the number of new immune cells already exist in principle, such as regenerating the thymus, or cell therapies in which...
Source: Fight Aging! - April 24, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How Drug Companies Keep Medicine Out of Reach - The Atlantic
http://www.theatlantic.com/health/archive/2013/05/how-drug-companies-keep-medicine-out-of-reach/275853/?ReutersFor almost a decade, the United States has been standing in the way of an idea that could lead to cures for some of the world's most devastating illnesses. The class of maladies is known as neglected diseases, and they almost exclusively affect those in the developing world. The same idea, if realized, might also be used in more affluent nations to goad the pharmaceutical industry into producing critical innovations that the free market has yet to produce - things like new antibiotics, which are likely to be used ...
Source: PharmaGossip - May 15, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs

Profit over Safety – Centers for Disease Control Names 271 New Vaccinations
Conclusion How many vaccinations will be considered to be a sensible number? If all of the vaccinations currently under development are deemed a success, how many of them will be added to the schedule? As there is little research to determine which ingredients are in the vaccinations listed as “under development” by the CDC, many parents are concerned about their toxicity and how best to protect their children. I will leave you with the wise words of Robert F, Kennedy Jr: “Vaccine industry money has neutralized virtually all of the checks and balances that once stood between a rapacious pharmaceutical industry and ou...
Source: vactruth.com - August 3, 2015 Category: Allergy & Immunology Authors: Christina England Tags: Christina England Logical Top Stories Centers for Disease Control (CDC) PhRMA Robert F. Kennedy Jr. World Health Organization (WHO) Source Type: blogs

What Experts in Law and Medicine Have to Say About the Cost of Drugs
By ANDY ORAM Pharmaceutical drug costs impinge heavily on consumers’ consciousness, often on a monthly basis, and have become such a stress on the public that they came up repeatedly among both major parties during the U.S. presidential campaign–and remain a bipartisan rallying cry. A good deal of the recent conference named Health Law Year in P/Review, at the Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics at Harvard Law School, covered issues with a bearing on drug costs. It’s interesting to take the academic expertise from that conference–and combine it with a bit of commo...
Source: The Health Care Blog - February 2, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Andy Oram Drug Pricing Pharma Source Type: blogs

20 Medical Technology Advances: Medicine in the Future – Part II.
Nanorobots swimming in blood vessels, in silico clinical trials instead of experimenting with drugs on animals and people, remote brain surgeries with the help of 5G networks – the second part of our shortlist on some astonishing ideas and innovations that could give us a glimpse into the future of medicine is ready for you to digest. Here, we’re going beyond the first part with medical tricorders, the CRISPR/Cas-9 gene-editing method, and other futuristic medical technologies to watch for. 11) In silico clinical trials against testing drugs on animals As technologies transform every aspect of healthcare,...
Source: The Medical Futurist - October 23, 2019 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence E-Patients Future of Medicine Future of Pharma Genomics Health Sensors & Trackers 3d printing AI bioprinting blockchain clinical trials CRISPR digital digital health drug development genetics Innovat Source Type: blogs

Indian Court Wants Stricter Clinical Trial Oversight
Amid ongoing concern over the conduct of clinical trials in India and patient protection, the Indian Supreme Court has slammed regulators for shoddy oversight that is creating “havoc” and leading to the deaths of many citizens. In sharp remarks, the government was criticized for going into a “deep slumber” and failing to establish mechanisms to stop “rackets” of multinational drugmakers, which are allegedly conducting illegal clinical trials around the country, according to various media reports (see here and here). “There has to be some sense of responsibility (on the part of the government). Hu...
Source: Pharmalot - January 7, 2013 Category: Pharma Commentators Authors: Ed Silverman Tags: Uncategorized Clinical Trials GlaxoSmithKline HPV India Vaccines Source Type: blogs