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Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
October 27, 2022 Edition-----In the UK we have a political farce running with only a day or so to run when you read this, with a new PM (Rishi Sunak) in place..In the US the mid-term elections are coming in a week or so, thus some concern as to where the US is going!In China Xi has his third 5 year term so we all wonder how that will turn out!In OZ we have has a Budget with floods, inflation, data leaks, the threat of recession, Medicare concerns and other issues just rolling on! At least the Budget does not seem to have broken anything!Overall an ‘omnishambles’ as they say!-----Major Issues.-----https://www.afr.com/wo...
Source: Australian Health Information Technology - October 27, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

How does stress cause heart disease? Cardiology Basics
Stress and heart disease have various aspects. Stress can lead to increase in risk factors for cardiovascular disease as well as precipitate symptoms in a hitherto silent cardiovascular disease. There is also a condition known as stress cardiomyopathy or broken heart syndrome, typically precipitated by an acute stressful event like loss of spouse in an elderly female. Most older persons have build-up of atherosclerotic plaques in the coronary arteries. When there is a sudden severe stress, heart rate and blood pressure can shoot up due to sympathetic overactivity. There is also the release of stress hormones like adrenali...
Source: Cardiophile MD - October 16, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Fine  particulate air pollution increases ventricular arrhythmias in adolescents – study report
Fine particulate air pollution increases ventricular arrhythmias in adolescents – study report Fine particles with aerodynamic diameters ≤2.5 μm (PM2.5) exposure has been associated with a risk of mortality and cardiac arrhythmias in adults [1]. Now a study has shown that PM2.5 is associated with acute increased number of ventricular arrhythmias in a population based sample of otherwise healthy adolescents [2]. The study analyzed data from 322 adolescents who participated in the Penn State Child Cohort follow‐up examination. PM2.5 exposure was measured using a nephelometer. A nephelometer or aerosol photomete...
Source: Cardiophile MD - September 17, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
September 15, 2022 Edition-----The death of QE2 has rather dominated the news for the last week or so and will probably pass after the funeral today.Otherwise the war in Ukraine seems to be in a turning phase. I hope that continues into the eventual getting rid of the Russians from Ukrainian territory!In OZ life goes on much as usual just awaiting the mourning period to pass,-----Major Issues.-----https://www.afr.com/policy/foreign-affairs/what-australia-should-do-about-taiwan-20220904-p5bf7iWhat Australia should do about TaiwanCanberra cannot be silent if US policy on Taiwanese independence changes. Quiet diplomacy is cal...
Source: Australian Health Information Technology - September 15, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

How IoT Medical Devices Save and Improve Lives
The following is a guest article by Erik Kling, Interim Head of IoT Americas at Vodafone Business. IoT, or the Internet of Things, has transformed our homes with connected lights and smart appliances. It’s also revolutionized all areas of business, including manufacturing. Sensors connected to the internet can track goods throughout the supply chain — from sourcing materials to delivering completed products to consumers. IoT technology has improved the way we live, but its most profound impact may be in healthcare, where it’s saving lives and improving health. Before IoT revolutionized healthcare, doctors and care pr...
Source: EMR and HIPAA - June 23, 2022 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Clinical Health IT Company Healthcare IT IT Infrastructure and Dev Ops AED American College of Cardiology Connected Defibrillators Continuous Glucose Monitors CPAP Dr. Ami Bhatt Elliot Erik Kling Healthcare AI Source Type: blogs

Wearable Sensor Uses Kirigami to Improve Skin Contact
Researchers at Osaka Prefecture University in Japan developed a wearable and wireless electrocardiogram monitor that employs kirigami, an ancient art of folding and cutting paper, to ensure better skin contact, stretchability, and breathability. The ...
Source: Medgadget - April 4, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Materials Sports Medicine Source Type: blogs

What is the scientific basis of 10,000 steps a day?
It is often suggested that you should take 10,000 steps a day, seven days a week as part of your fitness program. Actually the number of steps need not assess the amount of walking you do. The distance walked will depend on your stride length. Anyway the concept of 10,000 steps a day is quite popular and many use pedometers to track the daily step count and often post it on social media to encourage others. Thought of just looking at PubMed on the scientific data on the utility of 10,000 steps a day. Ohta T and colleagues checked the effect on coronary risk factors in obese middle aged subjects and the data was published ...
Source: Cardiophile MD - December 7, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: General Cardiology Source Type: blogs

EINSTEIN-Jr clinical trials of Rivaroxaban in children
Rivaroxaban is useful for treatment of venous thromboembolism in adults and is associated with lower risk of bleeding compared to standard anticoagulants. EINSTEIN-Jr phase 2 used bodyweight adjusted rivaroxaban for children with venous thromboembolism [1]. It was a single arm multicenter study three age groups – children younger than 6 months, those in age group 6 months to 5 years and in children and adolescents between 6-17 years. Studies were done at 54 sites across Australia, Europe, Israel, Japan and North America. The study was in children with confirmed venous thromboembolism who have been treated for at lea...
Source: Cardiophile MD - November 25, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: General Cardiology Source Type: blogs

Extremely high HDL – beneficial or harmful?
This study showed extremely high HDL was associated with lower risks for all-cause mortality and cardiovascular events compared to low HDL. But they had higher risks compared to very high HDL. Paradoxically high all-cause mortality in those with extremely high HDL has also been reported in another study of 52 268 men and 64 240 women [5]. Though most of these studies showed a negative role for extremely high HDL, there is recent study from Korea which showed that extremely high HDL was not associated with increased risk of mortality, myocardial infarction and stroke [6]. That study with 343,687 subjects also defined extrem...
Source: Cardiophile MD - October 20, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

Public access defibrillation
This study showed that trained lay persons can use AEDs safely and effectively. Nationwide dissemination of public access AEDs in Japan was reported in 2010 [1]. 312,319 adults who had out-of-hospital cardiac arrest were included in the study. 12,631 of these patients had ventricular fibrillation and cardiac origin witnessed cardiac arrest. 462 were administered shocks by lay persons with public access AEDs. Though this gave an average percentage of 3.7%, the percentage increased from 1.2% to 6.2% as the number of public access AEDs increased. 14.4% of those with witness cardiac origin cardiac arrest were alive at 1 month ...
Source: Cardiophile MD - August 17, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

Z- score classification of coronary aneurysms in Kawasaki disease
Z-score is the standard deviation from coronary artery internal lumen diameter normalized for body surface area. AHA classification of coronary artery aneurysms based on Z-score is as follows [1]: 1. No involvement with Z score less than 2 always. 2. Dilatation only with Z scores from 2 to less than 2.5 or a decrease in Z score of 1 or more during follow up if it was less than 2 initially. 3. Small aneurysm with Z score of more than 2.5, but less than 5. 4. Medium aneurysm with Z score 5 or more, but less than 5 and absolute dimension less than 8 mm. 5. Large or giant aneurysm with Z score 10 or more or absolute dimension...
Source: Cardiophile MD - July 24, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens. Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Reminder that Merely Elevated Blood Pressure Still Increases Cardiovascular Disease Risk
The old guidelines for systolic blood pressure drew the line for increased risk of cardiovascular disease at 140 mmHg, with higher systolic blood pressure defined as hypertension. That dividing line was then moved down to 130 mmHg. In the past few years, further evidence has shown that elevated systolic blood pressure of 120 mmHg or above still produces increased risk, and that one shouldn't feel comfortable and safe in the 120-129 mmHg range. The risk of cardiovascular disease scales up with increasing blood pressure, and as noted here, also with the modern lifestyle choices leading to excess fat tissue, metabolic disease...
Source: Fight Aging! - July 12, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs