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Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What is Fontan Paradox?
The term Fontan Paradox was coined by Marc de Leval in 2005 as paradox seen in Fontan circulation with caval hypertension, mainly in the splanchnic region and relative pulmonary arterial hypotension [1,2]. According to him, in a normal biventricular circulation, the mean caval pressures are less than 10 mm Hg and the mean pulmonary arterial pressure is at least 15 mm Hg to keep the pulmonary vasculature patent. He further suggested that a mechanical device capable of producing a step down in pressure energy of 5 mm Hg in the inferior vena cava and producing a step up of 5 mm Hg in the pulmonary arteries could potentially ...
Source: Cardiophile MD - June 9, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
A young lady with wide complex tachycardia. My first time actually making this diagnosis de novo in real life in the ED!
Written by Pendell MeyersA woman in her 30s with minimal past medical history presented simply stating she was " feeling unwell. " Her symptoms started suddenly about 48 hours ago, but had continued to worsen, including epigastric discomfort, nausea, cough, and dyspnea and lightheadedness on exertion. She denied chest pain and denied feeling any palpitations, even during her triage ECG:What do you think?Despite otherwise normal vital signs, she was appropriately triaged to the critical care area of the ED.She was awake, alert, well perfused, with normal mental status and overall unremarkable physical exam except for ...
Source: Dr. Smith's ECG Blog - June 3, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A teenager with chest pain, a troponin below the limit of detection, and " benign early repolarization "
Sent by anonymous, written by Pendell MeyersA male in his teens presented with complaints of chest discomfort and dyspnea beginning while exercising but without obvious injury. He immediately stopped exercising and symptoms started to improve. Later that evening he felt recurrent central chest discomfort, shortness of breath, and vomited. Symptoms have been constant since this second episode, and are still present on arrival, which seems to have been less than 1 to 2 hours from onset of symptoms. No similar symptoms in the past. No prior exertional complaints of chest pain, dizziness, lightheadedness, or undue shortness of...
Source: Dr. Smith's ECG Blog - January 9, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
What is domino heart transplantation?
In domino heart transplantation, the donor receives heart lung transplantation. The excised heart is transplanted to another recipient so that the donor for recipient of domino heart transplantation is alive, unlike the conventional donor who is brain dead.
In one report of 10 cases of domino heart transplantation, one year survival of donor was 60% while that of recipient was 90% [1]. It worthwhile noting that donors had terminal cardio pneumopathy (mostly primary pulmonary hypertension, one case of Eisenmenger syndrome and one each of cystic fibrosis, bronchiectasis, and bronchiolitis obliterans) while recipi...
Source: Cardiophile MD - November 27, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Awake ECMO
Extracorporeal membrane oxygenation (ECMO) is used for treatment of severe respiratory or cardiopulmonary failure. Usually these patients are sedated and mechanically ventilated, though at lower tidal volumes to reduce lung injury and permit lung recovery.
The concept of Awake ECMO is to do away with mechanical ventilation permitting the patient to eat, drink, sit up and even possibly walk. They can also participate in physiotherapy. One situation in which it is considered is in those who are in bridge to transplantation situation. One study documented 6 month survival after lung transplantation as 80% in the awake ECMO g...
Source: Cardiophile MD - November 6, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
In which situations are stress echocardiography useful?
Stress echocardiography is useful when exercise stress test is not feasible due to mobility issues. Stress echocardiography is usually done with dobutamine infusion to stress the myocardium. An important emerging role is in patients being prepared for liver transplantation. They are too sick for a treadmill exercise ECG. Invasive coronary angiography which is another alternative is not ideal due to the coagulation defect in such patients. Stress echocardiography is also useful when exercise ECG is not interpretable due to left bundle branch block. Another important role for stress echocardiography is when hibernating myoc...
Source: Cardiophile MD - November 3, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Can dark chocolates keep heart disease away? Cardiology Basics
A study published in ‘Circulation’ – the flagship journal of American Heart Association, suggested that eating dark chocolate can decrease your risk for myocardial infarction.
Myocardial infarction is usually due to a coronary obstruction, though there are other varieties as well, according to the Universal Definition of Myocardial Infarction. High oxidative stress and limited availability of antioxidants can cause endothelial damage in the arteries, leading to increased chances for a thrombosis.
Dark chocolates (which contain 70% cocoa) have lots of flavonoids – potent antioxidants which helps to overcome the oxi...
Source: Cardiophile MD - October 24, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Heart failure in chronic kidney disease – Cardiology Basics
Heart failure in chronic kidney disease – Cardiology Basics
Prevalence of both heart failure and chronic kidney disease (CKD) are increasing as the population is aging globally. Hence heart failure in chronic kidney disease is seen more often. Presence of CKD in heart failure increases morbidity and mortality. Though there is increasing use of effective medications and special devices like cardiac resynchronization therapy in heart failure patients in general, those with CKD have not been benefited well.
CKD is defined as abnormalities of kidney structure or function, present for >3 months, with implications for h...
Source: Cardiophile MD - October 21, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What is Eisenmenger syndrome? Cardiology Basics
Eisenmenger syndrome is a late complication of congenital heart diseases with large left to right shunts. Fortunately, it is rare now-a-days because most conditions which can cause Eisenmenger syndrome later, are detected by neonatal screening and treated early so that this complication does not develop later. Eisenmenger syndrome is a condition in which long standing high pulmonary blood flow leads to irreversible pulmonary hypertension with reversal of shunt. Right to left shunt causes reduced systemic oxygen saturation with cyanosis.
This is an echocardiogram showing a left to right shunt from the left ventricle to the...
Source: Cardiophile MD - October 20, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What is myocardial viability assessment? Cardiology Basics
Myocardial viability means regions of myocardium which can recover its function if the blood supply is normalized. Viable myocardium will improve after restoring blood supply while non-viable myocardium will not.
So myocardial viability assessment is important in deciding whether the person will benefit from revascularization procedures like coronary angioplasty and coronary bypass surgery.
There are two types of viable myocardium, stunned myocardium and hibernating myocardium. Stunned myocardium needs only time to recover while hibernating myocardium needs restoration of blood supply. Stunned myocardium is transient dela...
Source: Cardiophile MD - October 12, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What is dobutamine stress echocardiography? Cardiology Basics
Usual stress test for the heart is exercise ECG in which serial ECG recordings are done during a graded exercise protocol, usually on a treadmill. There are certain conditions like left bundle branch block in which an exercise ECG becomes uninterpretable. Some persons are unable to exercise on a treadmill due to illness or disability. In such situations dobutamine infusion is given instead of exercise, to increase heart rate and myocardial contractility, thereby increasing the workload of myocardium. Echocardiograms are taken then to assess the response of the myocardium to stress. This is known as dobutamine stress echoc...
Source: Cardiophile MD - October 11, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
September 15, 2022 Edition-----The death of QE2 has rather dominated the news for the last week or so and will probably pass after the funeral today.Otherwise the war in Ukraine seems to be in a turning phase. I hope that continues into the eventual getting rid of the Russians from Ukrainian territory!In OZ life goes on much as usual just awaiting the mourning period to pass,-----Major Issues.-----https://www.afr.com/policy/foreign-affairs/what-australia-should-do-about-taiwan-20220904-p5bf7iWhat Australia should do about TaiwanCanberra cannot be silent if US policy on Taiwanese independence changes. Quiet diplomacy is cal...
Source: Australian Health Information Technology - September 15, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Weekly Overseas Health IT Links –10th September, 2022.
This article is adapted fromVoices in the Code: A Story About People, Their Values, and the Algorithm They Made,out Sept. 8 from Russell Sage Foundation Press.In May 2021, I got a call I never expected. I was working on abook about A.I. ethics, focused on the algorithm that gives out kidneys to transplant patients in the United States. Darren Stewart —a data scientist from UNOS, the nonprofit that runs the kidney allocation process—was calling to get my take: How many decimal places should they include when calculating each patient’s allocation score? The score is an incredibly important number, given it determines w...
Source: Australian Health Information Technology - September 10, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
