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Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens.
Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 6th 2019
This study shows that mRNA levels of the aging related lamin A splice variant progerin, associated with premature aging in HGPS, were significantly upregulated in subjects with BMI ≥ 25 kg/m2. Moreover, our data revealed a significantly positive correlation of BMI with progerin mRNA. These data provide to our knowledge for the first-time evidence for a possible involvement of progerin in previously observed accelerated aging of overweight and obese individuals potentially limiting their longevity. Our results also showed that progerin mRNA was positively correlated with C-reactive protein (CRP). This might suggest an ass...
Source: Fight Aging! - May 5, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Our Visit to WIRED Health 2019 at London ’s Francis Crick Institute
WIRED Health, now in its sixth year, returned to London’s Francis Crick Institute. The event was opened by Crick Institute director Paul Nurse who introduced the institute and its mission to understand the fundamental biology of human health and d...
Source: Medgadget - April 2, 2019 Category: Medical Devices Authors: Tom Peach Tags: Exclusive Medicine Public Health Society Source Type: blogs
Fight Aging! Newsletter, January 14th 2019
In conclusion, reduction of LDL-C to less than 50 mg/dl seems safe and provides greater CV benefits compared with higher levels. Data for achieved LDL-C lower than 20-25 mg/dl is limited, although findings from the above mentioned studies are encouraging. However, further evaluation is needed for future studies and post-hoc analyses.
Wary of the Beautiful Fairy Tale of Near Term Rejuvenation
https://www.fightaging.org/archives/2019/01/wary-of-the-beautiful-fairy-tale-of-near-term-rejuvenation/
One might compare this interview with researcher Leonid Peshkin to last year's discussion with Vadim Gladyshev. ...
Source: Fight Aging! - January 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 20th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - August 19, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Doctors Discuss Future of Medicine on eMedicoz: India's First Medical Education Centric Mobile app
Note by Dr Sumer Sethi Recently we launched our unique medical education centric app for young Doctors calledeMedicoz. On this in addition to routine discussions Doctors also discuss various aspects of the profession. In a recent discussion series young Doctors brainstormed and tried crystal balling the future of the medicine and technology. It is wonderful to hear their thoughts on future. It is for certain future looks really happening for medical profession, computers and machine learning will re- invent the way we practice medicine. Targeted therapy is another important area, 3D printing , understanding the value ...
Source: Sumer's Radiology Site - April 2, 2018 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Most important cardiotoxicity of immune checkpoint inhibitors – Cardiology MCQ – Answer
Most important cardiotoxicity of immune checkpoint inhibitors – Answer
Interactive Kindle Edition: Check here for more Cardiology MCQs!
Cardiotoxicity of immune checkpoint inhibitors – Correct answer: 1. Fulminant myocarditis
Immunotherapy with immune checkpoint inhibitors is becoming standard of care for multiple types of malignancies. Important immune checkpoint inhibitors are ipilimumab which acts against cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); nivolumab and pembrolizumab which act against programmed cell death 1 (PD-1) and atezolizumab which targets PD-1 ligand (PD-L1).
Autoimmune fulminan...
Source: Cardiophile MD - March 25, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Medgadget Sci-Fi Contest 2017: Meet The Winning Stories
Ladies and Gentlemen, this is the moment you have all been waiting for – the day that the winners of the Medgadget Medical Sci-Fi Competition are announced and their fantastic stories are published!
First, we would like to thank Eko Devices, th...
Source: Medgadget - December 15, 2017 Category: Medical Devices Authors: Editors Tags: Exclusive Source Type: blogs
Why “ Precision Health ” May Not Be the Precise Word
By DAVID SHAYWITZ, MD
The appeal of precision medicine is the promise that we can understand disease with greater specificity and fashion treatments that are more individualized and more effective.
A core tenet (or “central dogma,” as I wrote in 2015) of precision medicine is the idea that large disease categories – like type 2 diabetes – actually consist of multiple discernable subtypes, each with its own distinct characteristics and genetic drivers. As genetic and phenotypic research advances, the argument goes, diseases like “type 2 diabetes” will go the way of quaint descriptive diagnoses like “dropsy”...
Source: The Health Care Blog - November 28, 2017 Category: Consumer Health News Authors: John Irvine Tags: OP-ED Uncategorized Broad Institute CAD Circulation Disease Categories Gimish Model of Disease Kathiresan Khera Massachussetts General Hospital Source Type: blogs
A New Gimish Model of Complex Disease?
By DAVID SHAYWITZ, MD
The appeal of precision medicine is the promise that we can understand disease with greater specificity and fashion treatments that are more individualized and more effective.
A core tenet (or “central dogma,” as I wrote in 2015) of precision medicine is the idea that large disease categories – like type 2 diabetes – actually consist of multiple discernable subtypes, each with its own distinct characteristics and genetic drivers. As genetic and phenotypic research advances, the argument goes, diseases like “type 2 diabetes” will go the way of quaint descriptive diagnoses like “dropsy”...
Source: The Health Care Blog - November 28, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Broad Institute CAD Circulation Disease Categories Gimish Model of Disease Kathiresan Khera Massachussetts General Hospital Source Type: blogs
A More Precise Definition of Precision Medicine?
By DAVID SHAYWITZ, MD
The appeal of precision medicine is the promise that we can understand disease with greater specificity and fashion treatments that are more individualized and more effective.
A core tenet (or “central dogma,” as I wrote in 2015) of precision medicine is the idea that large disease categories – like type 2 diabetes – actually consist of multiple discernable subtypes, each with its own distinct characteristics and genetic drivers. As genetic and phenotypic research advances, the argument goes, diseases like “type 2 diabetes” will go the way of quaint descriptive diagnoses like “dropsy”...
Source: The Health Care Blog - November 28, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Broad Institute CAD Circulation Disease Categories Gimish Model of Disease Kathiresan Khera Massachussetts General Hospital Source Type: blogs
The Most Exciting Medical Technologies of 2017
It is almost a tradition for me to publish predictions for the coming year. I do not mean to disappoint you this year either, so here you find some thoughts about the top medical technologies of 2017.
2016 was a rich year for medical technology. Virtual Reality. Augmented Reality. Smart algorithms analysing wearable data. Amazing technologies arrived in our lives and on the market almost every day. And it will not stop in the coming year.
The role of a futurist is certainly not making bold predictions about the future. No such big bet has taken humanity forward. Instead, our job is constantly analysing the trends shaping t...
Source: The Medical Futurist - December 15, 2016 Category: Information Technology Authors: nora Tags: Future of Medicine 3d printing AI artificial intelligence diabetes GC1 genetics Healthcare Innovation nutrigenomics Personalized medicine robotics wearables Source Type: blogs
Fight Aging! Newsletter, June 20th 2016
We examined the engraftment and differentiation of alkaline phosphatase-positive NSCs expanded from the postnatal subventricular zone (SVZ), 3 months after grafting into the intact young or aged rat hippocampus. Graft-derived cells engrafted robustly into both young and aged hippocampi. Although most graft-derived cells pervasively migrated into different hippocampal layers, the graft cores endured and contained graft-derived neurons.
The results demonstrate that advanced age of the host at the time of grafting has no major adverse effects on engraftment, migration, and differentiation of grafted subventricular zone...
Source: Fight Aging! - June 19, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
