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Total 59 results found since Jan 2013.

Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reviewing Efforts to Use Cells and Scaffolds to Regenerate the Heart
The heart is one of the least regenerative tissues in the body. Damage resulting from loss of blood flow during a heart attack leads to scarring and loss of function, rather than any meaningful degree of regeneration. While preventing the atherosclerosis that causes occlusion of blood vessels is the most desirable goal, finding ways to repair a damaged heart is also a high priority for the research community. Many groups have worked towards regenerative therapies based on delivery of cells and scaffolding material, even layers of artificial tissue made by combining the two, but progress has been frustratingly slow. ...
Source: Fight Aging! - July 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Advantages of Left ventricular hypertrophy (LVH)
This is a 15-year-old post about LVH, written in 2008. Few of my colleagues, now agree with this, but still hesitate to oblige in  the open, suggesting it is too good to be true! Re-posting it for your own assessment. Surprised, why cardiology community didn’t consider this observation worthy to pursue. Advantages of Left ventricular hypertrophy (LVH) Left ventricular hypertrophy is one of the most common clinical cardiac entity.It is recognised either by ECG or echocardiography.LVH has a unique place in cardiology as it can imply a  grossly pathological state or  a marker of healthy heart as in physiologica...
Source: Dr.S.Venkatesan MD - May 4, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs

Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo. T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/ Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree Towards Scaffold-Based Regeneration of Dental Pulp https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/ Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth h...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Lipid Nanodiscs Unlock the Potential of Cytokine Treatment
Researchers at the University of Texas at Austin created a nanocarrier for stem cell factor, a regenerative cytokine. The nanotechnological approach renders the treatment much safer, as previous attempts to use stem cell factor as a pro-angiogenic tr...
Source: Medgadget - June 13, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Medicine Nanomedicine Source Type: blogs

Heart Chamber on a Chip
Researchers at Boston University engineered a heart chamber on a chip that can beat by itself. The technology relies on cardiomyocytes generated from induced pluripotent stem cells and small acrylic valves that allow the fluid pumped by the chamber t...
Source: Medgadget - April 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Genetics Materials artificial heart bu_tweets Source Type: blogs

Futuristic cardiology: Fishing a failing heart !
A path-breaking research is coming up from Jhon Paulson school of engineering, Harvard. It is all about a tiny lab-made bio-hybrid fish that is mechanically engineered with cardiac stem cells. It can generate enough mechanical force that can transform into a biological organ (or assistance)to the heart. Early lab experiments are exciting. We will soon see a stem cell-enriched bio-fish that will dance to the tunes of the cardiac cycle. (See the video below)  Final message Will it become real? or a just a grandeur thought? We have just done Xeno heart transplantat...
Source: Dr.S.Venkatesan MD - February 20, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized bio organism as artificial organ donor future of cardiology heart transplanation xeno transplantation Source Type: blogs

Lab-Designed “Fish” Could Pave the Way for Artificial Hearts
Researchers at Harvard University have created a fish-like construct from human stem cell-derived cardiac muscle. The structure can beat and swim autonomously, and is inspired by zebrafish. So far, the researchers have shown that the fish can survive...
Source: Medgadget - February 15, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Materials Source Type: blogs

Heart Model Simulates Mechanical Load on Cardiac Tissues
Researchers at Carnegie Mellon University, along with collaborators in the Netherlands, have developed a heart model consisting of engineered cardiac muscle tissue that is attached to an elastic material. The design allows the team to mimic the mecha...
Source: Medgadget - July 26, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Materials Source Type: blogs

Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens. Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cardiac Organoids Self-Organize to Mimic Human Heart
Researchers at the Austrian Academy of Sciences have developed the most realistic cardiac organoids to date. The tiny structures self-organize from pluripotent stem cells to form a hollow chamber that can beat. The method to create the ‘cardioids...
Source: Medgadget - May 25, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Materials Source Type: blogs

Fight Aging! Newsletter, April 12th 2021
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders. Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause-...
Source: Fight Aging! - April 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

LA myxoma surgery : Preventing recurrence should be an important goal.
Cardiac myxoma is the most common primary tumor of the heart that presents as mitral inflow obstruction/ regurgitation often with a systemic presentation. It can be either familial, syndromic, or sporadic. Excellent imaging is possible and diagnosis has become straightforward. Surgery is the specific treatment, What information do the Surgeons need?  Size, attachment to surrounding structures is the key. The myxoma origins most often in IAS and defining its attachment is crucial. Mitral leaflet distortion, Injury ( and even attachment) is possible. It is helpful for the surgeons if we let them know the mechanism of mit...
Source: Dr.S.Venkatesan MD - December 13, 2020 Category: Cardiology Authors: dr s venkatesan Tags: Cardiac myxoma IAS patch closure for myxoma LA myxoma surgery mesenchymal cell tumor myxoma myxoma benign or malignant Source Type: blogs

Alginate Biomaterial Evades Immune System to Enhance Stem Cell Therapy
Researchers at Rice University and Baylor College of Medicine have developed an immuno-evasive alginate biomaterial hydrogel that can enhance stem cell therapy after myocardial infarction. Stem cells delivered to the heart within the biomaterial surv...
Source: Medgadget - August 19, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Materials Medicine Source Type: blogs