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Nature vs Nurture
  By, SAURABH JHA MD My wife chooses sides in the nature-versus-nurture war expeditiously. When our children are polite, she credits her nurture. When they’re rowdy, she blames my genes. But the nature-nurture war won’t be resolved anytime soon. The gene played a significant role in the great Indian epic, the Mahabharata. Karna, abandoned by his mother, Kunti, and raised by a charioteer, was taught warfare by Parashurama, a gifted teacher with a fiery temperament, who despised warriors and only taught Brahmins. One day, Parashurama was asleep with his head on Karna’s lap. Karna was bitten by a scorpion but d...
Source: The Health Care Blog - April 29, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

News From 2055: Gene Therapy Went Wrong? Mother Dies After Fetus Breaks Out Of Womb
A short story written by Margit Hilland Laerum as part of Dr. Bertalan Meskó’s course: Lessons in Digital Health at Semmelweis University. The dystopic scenario details possible consequences of gene therapies that might make us think about how to prevent ethical issues in time. Following the death of 26-year-old Petra Pollutino, NYPD has confirmed that the woman bled to death as a result of her 6-month old fetus bursting out of her womb.  Pollutino was attending a tennis match Saturday, 14 August 2055 at the New York Tennis Club when she suddenly fell ill. Witnesses reported gruesome scenes. They described Pollu...
Source: The Medical Futurist - February 27, 2018 Category: Information Technology Authors: nora Tags: Medical Science Fiction future gene therapy genetics Healthcare Medicine scifi short story technology Source Type: blogs

Rejuvenate Bio to Launch a Gene Therapy Trial for Heart Failure in Dogs
One of the many possible paths towards developing a new medical technology is to first focus on veterinary use. It is considerably less costly in time and resources to develop a therapy for dogs, say, than it is to develop a therapy for humans. Later, given robust success in veterinary medicine, the therapy can be brought into the sphere of human medicine. This is the approach taken by Rejuvenate Bio for their class of regenerative gene therapies. As noted here, the company is moving forward to trials in companion animals, starting later this year. Back in 2015, the Church lab at Harvard began testing a variety of...
Source: Fight Aging! - May 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 20th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - May 19, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Journalists Have Very Fragmentary, Incomplete Views of the Longevity Industry
The lengthy and somewhat overwrought article I'll point out today is a good example of the way in which journalists fail when writing on the topic of the growing biotechnology industry that is making the first steps towards the medical control of aging. They talk to just a few people, and thus have a very narrow (generously) or absolutely incorrect (more accurately) view of what might be happening, the prospects for the future, and the shape of the field as a whole. In this case the few people are the folk at AgeLab at MIT, and George Church, with a focus on the veterinary deployment of gene therapies by Rejuvenate Bio, an...
Source: Fight Aging! - May 21, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, May 27th 2019
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - May 26, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How Much Is Life Worth?
Multivitamins, drugs, gene therapies, human skin, heart, eyeballs, kidneys, entire dead bodies – everything comes with a price tag. Putting aside the moral questions of why and how come that the capitalist market priced even our body parts and health, we asked the question of how much is life worth: what is the maximum that you would/should pay for a life-saving drug? How high is too high a cost if a drug can save 200-300 babies a year from debilitating illness or death? And ultimately, does the pricing of new technologies, especially gene therapies, enable to fulfill their promise? There’s a price for everything: ...
Source: The Medical Futurist - August 31, 2019 Category: Information Technology Authors: nora Tags: Bioethics Biotechnology Future of Pharma Genomics cost daraprim drug drug price Gene gene therapy genetics insulin life medication pricing policy rare disease rare disorder Source Type: blogs