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Source: The Journal of Pain

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Total 79 results found since Jan 2013.

Anxiety, disability, and pain predict outcomes of Complex Regional Pain Syndrome: An 8-year follow-up of a prospective cohort
This study aimed to determine whether baseline psychological factors, pain, and disability influence long-term CRPS outcomes. We conducted an 8-year follow-up from a previous prospective study of CRPS outcomes. Sixty-six people diagnosed with acute CRPS were previously assessed at baseline, 6 months, and 12 months and in the current study, 45 were followed up after 8 years. At each timepoint, we measured: signs and symptoms of CRPS, pain, disability, and psychological factors.
Source: The Journal of Pain - June 14, 2023 Category: Materials Science Authors: Shari A. Cave, Lisa M. Reynolds, Natalie L. Tuck, Tipu Aamir, Arier C. Lee, Debbie J. Bean Tags: Original Reports Source Type: research

Keratinocyte PIEZO1 Contributes To Peripheral Sensitization In A Rat Model Of Complex Regional Pain Syndrome
Patients suffering from complex regional pain syndrome (CRPS) often present with debilitating mechanical allodynia in the skin of the affected limb. To explore the mechanism underlying peripheral nociceptive sensitization in CRPS and seek therapies targeting the periphery without affecting the central nervous system, we studied the role of keratinocyte mechanosensitive PIEZO1 channel in CRPS models. We induced ischemia-reperfusion (I/R) injury for establishing in vivo chronic post-ischemia pain (CPIP) rat model and in vitro oxygen-glucose deprivation reperfusion (OGD/R) cultured cell model to mimic CRPS.
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Jijun Xu, Bei Wen, Li Xu, Yuguang Huang Source Type: research

Skin Resident Memory T Cell Dysfunction In The Tibia Fracture Model Of Complex Regional Pain Syndrome
Complex regional pain syndrome (CRPS) is a debilitating chronic pain disorder that with no effective treatments. Several microRNA (miRNA) are commonly dysregulated in CRPS patient and tibia fracture model of CRPS (TFM) mice, including miR-25 which is associated with positive treatment outcomes in patients. Interestingly, these miRNAs are predicted to target several genes critical to resident memory T cell (Trm) function. We hypothesize that miRNA dysregulation contributes to the pathology of CRPS through regulation of skin Trm development and maintenance.
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Jason Wickman, Botros Shenoda, Rachel Van Duyne, Zachary Kline, Seena Ajit Source Type: research

Newly Repopulated Spinal Cord Microglia Exhibit A Unique Transcriptome And Coincide With Sex-Independent Pain Resolution
The transition from acute-to-chronic pain is important because underlying mechanisms may reveal targets for the treatment of chronic pain. Spinal cord microglial activation results from persistent neuronal hyperexcitability, and this can trigger feedforward synaptic plasticity that contributes to chronic pain. We used a targeted, inducible genetic microglial depletion strategy in the clinically relevant tibial fracture/casting model of complex regional pain syndrome (CRPS) to interrogate the contribution of microglia to pain progression.
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Caldwell M. Bridges, Lauren J. Donovan, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Claire E. Jordan, Aysha S. Gardner, Ramesh V. Nair, Vivianne L. Tawfik Source Type: research

Distress and resilience narratives within pain memories of adolescents and young adults with complex regional pain syndrome: A multi-method study
Complex regional pain syndrome (CRPS) is a persistent, localized chronic pain condition that typically affects the extremities (57). Prevalence of CRPS in pediatric populations is estimated at 1.16/1000, with higher rates in females and peak onset during adolescence (1). As a primary pain condition, young people with CRPS report significantly elevated levels of pain compared to young people with other conditions including chronic back or abdominal pain (32). Previous literature has focused on examining pain-related disability and functioning in chronic pain more broadly (48) and also in relation to CRPS (50,52), while rece...
Source: The Journal of Pain - March 1, 2023 Category: Materials Science Authors: Emy Nimbley, Line Caes, Melanie Noel, Abbie Jordan Tags: Original Reports Source Type: research

Clinical assessment of mechanical allodynia in youth with complex regional pain syndrome: Development and preliminary validation of the Pediatric Tactile Sensitivity Test of Allodynia (Pedi-Sense)
Mechanical allodynia is a hallmark of pediatric complex regional pain syndrome (CRPS), defined as pain induced by a non-noxious mechanical stimulus (e.g., light touch) possibly due to disruption in feed-forward inhibitory circuits in the spinal cord dorsal horn;29 however, the precise mechanism is unknown. Mechanical allodynia (in addition to concomitant pain at rest, sudomotor, and vasomotor changes) is distressing, refractory to medications, and commonly leads to disability in youth with CRPS because it interferes with engagement in age-appropriate activities such as wearing clothing, weight-bearing, or riding in a car.
Source: The Journal of Pain - December 29, 2022 Category: Materials Science Authors: Julie Shulman, Anna Cybulski, Edin Randall, Kimberly F. Greco, Gabrielle Bryant, Kelsey Jervis, Edie Weller, Navil F. Sethna Tags: Original Reports Source Type: research

Perioperative Oxidative Stress Prospectively Predicts CRPS-Related Outcomes in the 6 months Following Total Knee Arthroplasty
This project tested whether oxidative stress (OS) related to extended tourniquet application during total knee arthroplasty (TKA) and subsequent ischemic reperfusion contributed to CRPS outcomes up to 6 month following TKA. Blood samples were obtained in 90 osteoarthritis patents (63.3% female; 95.6% Non-Hispanic White) undergoing TKA prior to tourniquet placement (T1), 45 minutes after tourniquet inflation (T2), and 15 minutes following tourniquet removal (T3). Plasma levels of F2-isoprostanes (IsoPs) and isofurans (IsoFs), the most specific measures of in vivo OS, were quantified.
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Stephen Bruehl, Frederic T. Billings IV, Sara Anderson, Gregory Polkowski, Andrew Shinar, Jonathan Schildcrout, Yaping Shi, Ginger Milne, Anthony Dematteo, Puneet Mishra, R. Norman Harden Tags: 7 Source Type: research

Clinical and neurophysiological effects of progressive movement imagery training for pathological pain
Movement limitation is a common characteristic of chronic pain such that pain prevents the very movement and activity that is most likely to promote recovery. This is particularly the case for pathological pain states such as complex regional pain syndrome (CRPS). One clinical approach to CRPS that has growing evidence of efficacy involves progressive movement imagery training. Graded Motor Imagery (GMI) targets clinical and neurophysiological effects through a stepwise progression through implicit and explicit movement imagery training, mirror therapy and then functional tasks.
Source: The Journal of Pain - April 29, 2022 Category: Materials Science Authors: Martin Lotze, G. Lorimer Moseley Tags: Focus Article Source Type: research

Preoperative Predictors of Complex Regional Pain Syndrome Outcomes in the 6 Months Following Total Knee Arthroplasty
Complex Regional Pain Syndrome (CRPS) is a chronic pain condition typically beginning in a single limb that is characterized by spontaneous pain, allodynia and hyperalgesia, edema, changes in skin temperature and color, altered sweating, and motor and trophic changes7. CRPS appears to have multiple interacting mechanisms, including central and peripheral sensitization, autonomic changes, enhanced inflammatory and immune activity, and altered limb representation in the brain6,7. Limited epidemiological work suggests CRPS disproportionately affects women and individuals in middle age17,66, and fracture and surgery appear to ...
Source: The Journal of Pain - April 22, 2022 Category: Materials Science Authors: Stephen Bruehl, Frederic.T.Billings IV, Sara Anderson, Gregory Polkowski, Andrew Shinar, Jonathan Schildcrout, Yaping Shi, Ginger Milne, Anthony Dematteo, Puneet Mishra, R. Norman Harden Tags: Original Reports Source Type: research

Microvascular barrier protection by microRNA-183 via FoxO1 repression: A pathway disturbed in neuropathy and complex regional pain syndrome
Although widely prevalent, neuropathic and chronic pain remain a challenge to treat due to its diverse underlying etiologies, varying clinical presentations and a still incomplete molecular understanding. Complex regional pain syndrome (CRPS) is a rare primary chronic pain syndrome – occurring after fracture or surgery of an extremity. In addition to pain, common features of CRPS include allodynia, edema, sweating, temperature, skin color, and trophic changes as well as motor disturbances at the affected extremity.
Source: The Journal of Pain - December 30, 2021 Category: Materials Science Authors: Ann-Kristin Reinhold, Ellaine Salvador, Carola Y F örster, Frank Birklein, Heike L Rittner Source Type: research

Substance P serum degradation in Complex Regional Pain Syndrome – another piece of the puzzle?
In a previous study, we demonstrated that the serum peptidase system might be less efficient in complex regional pain syndrome (CRPS). Since the neuropeptide substanc P (SP) contributes to inflammation in CRPS, we now investigated the metabolism of SP in CRPS specifically. An SP metabolism assay was performed in 24 CRPS patients, which constitute a subgroup of our previous investigation on BK degradation. In addition, we included 26 healthy controls (24 newly recruited plus 2 from our previous investigation), and 13 patients after limb trauma, who did not fulfil the CRPS diagnostic criteria (trauma controls, TC) were included.
Source: The Journal of Pain - October 19, 2021 Category: Materials Science Authors: Simone K önig, Christian Engl, Malte Bayer, Fabiola Escolano-Lozano, Heike Rittner, Cora Rebhorn, Frank Birklein Source Type: research

Pupillary reflexes in complex regional pain syndrome: asymmetry to arousal stimuli suggests an ipsilateral locus coeruleus deficit
In complex regional pain syndrome (CRPS), the initial response to limb injury evolves into an intractably painful condition associated with sensory, autonomic, motor and trophic disturbances 5,41. Sensory disturbances often encompass much of the body, particularly on the affected side 10-12,15,39, possibly due to central sensitization and/or failure of inhibitory pain controls.
Source: The Journal of Pain - August 7, 2021 Category: Materials Science Authors: Peter D. Drummond, Philip M. Finch Tags: Original Reports Source Type: research

Validation of the Bath CRPS Body Perception Disturbance Scale
Complex Regional Pain Syndrome (CRPS) is characterized by pain; and autonomic, sensory, and motor symptoms affecting one or more limb(s). An estimated 70-90% of people with CRPS report disturbances in their body perception.20 These disturbances can involve mismatches between the actual and perceived position, size, weight, pressure, or temperature of the affected limb.29 People with CRPS may also report that their affected limb feels detached from the rest of their body; or that they avoid looking at, experience negative emotions towards, or have a desire to amputate it.
Source: The Journal of Pain - May 5, 2021 Category: Materials Science Authors: Antonia F. Ten Brink, Monika Halicka, Axel D. Vitters ø, Hannah G. Jones, Tasha R. Stanton, Janet H. Bultitude Tags: Original Reports Source Type: research

Evolving understanding of the classification of fibromyalgia following surgery
Fibromyalgia (FM) is a condition characterized by chronic widespread pain, psychological disturbances, and physical impairments with controversy surrounding the underlying pathophysiology and no diagnostic confirmatory test. There are many shared features between FM and CRPS, and we theorize that some sub-set of clinically diagnosed FM is the result of a diffuse form of CRPS. Our objective in this case series is to outline two post-surgical patients with eventual diagnosis of FM. Case Report Case 1: African-American male veteran with medical history significant for repeat incision and drainage of sebaceous cysts in his bilateral axilla.
Source: The Journal of Pain - May 1, 2021 Category: Materials Science Authors: Arjun Meka, Dabin Ji, Anna Woodbury Source Type: research

Patients describe their lived experiences of battling to live with Complex Regional Pain Syndrome
Complex Regional Pain Syndrome (CRPS) is a condition which is difficult to diagnose, difficult to treat, and unlike other chronic pain conditions, it can spread to encompass other parts of the body 8, 32, 48. It is reputed to be the most painful condition known to man as measured by the McGill Pain scale, rating higher than amputation of a digit, childbirth and cancer pain 8, 32, 59. Previously known as reflex sympathetic dystrophy (RSD), causalgia and shoulder-hand syndrome, CRPS is largely unknown in the general public and many health professionals will not encounter or recognise it in clinical practice 8, 38.
Source: The Journal of Pain - April 20, 2021 Category: Materials Science Authors: Dr Colleen Johnston-Devin, Florin Oprescu, Marion Gray, Marianne Wallis Tags: Original Reports Source Type: research