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“ N-of-1 ” research – A clinically relevant research strategy!
I’ve been banging on about single case experimental research designs (SCED) ever since I studied with Prof Neville Blampied at University of Canterbury. Prof Blampied (now retired) was enthusiastic about this approach because it allows clinicians to scientifically test whether an intervention has an effect in an individual – but he took it further with a very cool graphical analysis that allows multiple cases to be studied and plotted using the modified Brinley Plot (Blampied, 2017), and I’ll be discussing it later in this series. Suffice to say, I love this approach to research because it allows clinicia...
Source: HealthSkills Weblog - February 12, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Coping Skills Occupational therapy Professional topics Psychology Research Science in practice healthcare pain management Source Type: blogs

Managing Psychiatric Symptoms in Patients with Complex Regional Pain Syndrome
by Jonathan R. Scarff, MD Dr. Scarff is with Lexington Veterans Affairs Medical Center in Lexington, Kentucky.  Funding: No funding was provided for this study.   Disclosures: The author has no conflicts of interest relevant to the content of this article Innov Clin Neurosci. 2022;19(1–3):56–59. ABSTRACT: Complex regional pain syndrome (CRPS) is a rare but […] The post Managing Psychiatric Symptoms in Patients with Complex Regional Pain Syndrome appeared first on Innovations in Clinical Neuroscience.
Source: Innovations in Clinical Neuroscience - January 1, 2022 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Pain Psychiatry Review anxiety CRPS depression immune system nervous system Source Type: research

TRPV1 Channel Contributes to the Behavioral Hypersensitivity in a Rat Model of Complex Regional Pain Syndrome Type 1
This study was carried out in accordance with National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. 8023, revised 1978) and approved by the Animal Ethics Committee of Zhejiang Chinese Medical University. Author Contributions QH performed the western blot, immunostaining, and behavioral test. QW performed the patch clamp experiments. CW supervised the patch clamp experiments. QH and BoyuL performed the behavioral test. YT, XS, and JF analyzed the data and reviewed the manuscript. BoyiL designed, supervised the study, and wrote the manuscript. Funding This project was suppor...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research

Opioid Induced Hyperalgesia Prevented by Buprenorphine?
“Buprenorphine is a kappa receptor antagonist. For these reasons, buprenorphine might be unique in its ability to treat chronic pain and possibly OIH.” The opioid crisis has been fueled by the use of opioids to treat chronic pain.  Practice patterns have changed, but doctors are still criticized for their roles in the overuse of opioids.  I’ve sat through community ‘heroin forums’ (sometimes on stage) as sheriffs, politicians, and ‘recovered addicts’ firmly pointed fingers at health professionals.  I, meanwhile, kept my finger under the table, but had the thought that some of the people pointing ...
Source: Suboxone Talk Zone - February 5, 2017 Category: Addiction Authors: Jeffrey Junig MD PhD Tags: Acute Pain Buprenorphine Chronic pain Suboxone treatment buprenorphine treats chronic pain chronic pain treatment opioid induced hyperalgesia opioid pain relief pain vs. addiction Source Type: blogs

Scientific Educational Workshops and Conferences
The objectives of this agreement are: 1. Coordinate efforts to engage GWS members, cultural and natural area managers, private and public sector agencies, and other organizations in cooperative activities with the NPS to address protected area research, conservation, and management challenges through the GWS Biennial Conferences on Parks, Protected Areas and Cultural Sites. 2. Improve partnership efforts with adjacent and related protected areas (federal, state, tribal, private, and international) to conserve natural and cultural resources and landscapes and promote natural and cultural resource-based recreational opportu...
Source: Grants.gov - June 9, 2014 Category: Research Tags: Community Development Education Environment Natural Resources Regional Development Science and Technology and other Research and Development Source Type: funding